Araştırma Makalesi
BibTex RIS Kaynak Göster

Comparıson of Simultaneous Integrated Boost Method for Different Treatments in Head and Neck Cancer Radiotherapy

Yıl 2017, Cilt: 29 Sayı: 1, 20 - 28, 21.04.2017
https://doi.org/10.7240/marufbd.306338

Öz

A comparative planning study was undertaken to evaluate dosimetric differences between volumetric modulated arc therapy versus intensity
modulated radiation therapy in the treatment of head and neck. Patients were investigated, with a standard prescription of three dose
levels to the target volumes in 33 fractions. Simultaneous Integrated Boost technique was generated for all techniques, with similar planning
objectives. Plans were calculated for 6MV photon using anisotropic analytical algorithm implemented in Eclipse treatment planning
system. 9 field IMRT and 2 arc VMAT plans show superior dose homogeneity and dose conformity in PTVs. Doses to optic nerves, chiasm,
eyes, lenses and protists were slightly lower in 7, 9 field IMRT plans. Doses to the brain stem, spinal cord, mandibula and larynx were
better in the 2 arc VMAT techniques. Oral cavity dose reduced significantly with 1 arc VMAT. The high dose radiation volume to the normal
tissue and the mean normal tissue dose decreased, but the low dose radiation volume increased slightly in the 1 and 2 arc VMAT plans.
1, 2 arc VMAT and 7, 9 field IMRT plans produced clinically acceptable treatment plan for the head and neck cancer. VMAT represents an
attractive solution because of the shorter delivery time and the lower of monitor unit compared with IMRT.

Kaynakça

  • 1 Nath, R., Biggs, P.J., Bova, F.J., Ling, C.C., Purdy, J.A., van de Geijn, J., Weinhous, M.S. (1994). SYN45 : AAPM Code of Practice for Radiotherapy Accelerators, Report of AAPM Radiation Therapy Task Group, USA.
  • 2 Edward, C.H., Carlos, A.P., Luther, W.B. (2007). Perez and Brady’s Principles and Practice of Radiation Oncology. Lippincott Williams&Wilkins (ed.), 5. baskı, New York, USA.
  • 3 Hall, E.J., Giaccia, A.J. (2006). Radiobiology for the radiologist. Lippincott Williams&Wilkins (ed.), 6. baskı, Philadelphia, USA.
  • 4 Carol, M.P. (1995). A system for planning and rotational delivery of intensity-modulated fields. International journal imaging systems technology, 6, 56-61.
  • 5 Ling, C.C., Burman, C., Chui, C.S. (1996). Conformal radiation treatment of prostate cancer using inversely-planned intensity-modulated photon beams produced with dynamic multileaf collimation. International Journal of Radiation Oncology Biology Physics, 35(4), 721-730.
  • 6 International Commission on Radiation Units and Measurements. (2010). Prescribing, Recording, and Reporting Photon-Beam Intensity-Modulated Radiation Therapy (IMRT), Oxford University, ICRU Report 83, UK.
  • 7 Carol, M.P., Targovnik, H., Smith, D. (1992). 3-D planning and delivery system for optimized conformal therapy. International Journal of Radiation Oncology Biology Physics, 24, 158.
  • 8 Mundt, A.J., Roeske, J.C. (2005). Intensity Modulated Radiation Therapy A Clinical Perspective. BC Decker (ed.), 5. baskı, Hamilton, USA.
  • 9 James, D.C., Kian, A. (2010). Radiation Oncology: Rationale, Technique, Results. Mosby Elsevier (ed.), 9. baskı, Philadelphia, USA.
  • 10 Paul, Q.M., Peter, H.R.E., Patrick, J.G. (2009). Principles and Practice of Head and Neck Surgery and Oncology. Informa healthcare (ed.), 2. baskı, New York, USA.
  • 11 Otto, K. (2007). Volumetric modulated arc therapy: IMRT in a single gantry arc. Medical Physics, 35(1), 310. 12 Khan, F.M. (2003). The Physics of Radiation Therapy. Lippincott Williams&Wilkins (ed.), 4. baskı, Philadelphia, USA.
  • 13 Khan, F.M., Gibbons, J.P. (2014). Treatment Planning in Radiation Oncology. Lippincott Williams&Wilkins (ed.), 5. baskı, Philadelphia, USA.
  • 14 Lauve, A., Morris, M., Schmidt-Ullrich, R. (2004). Simultaneous integrated boost intensity-modulated radiotherapy for locally advanced head and neck squamous cell carcinomas: II clinical results. International Journal of Radiation Oncology Biology Physics, 60(2), 374-387.
  • 15 Mohan, R., Wu, Q., Manning, M., Schmidt-Ulrich, R. (2000). Radiobiological considerations in teh design of fractionation strategies for intensity-modulated radiation therapy of head and neck cancers. International Journal of Radiation Oncology Biology Physics, 46(3), 619-630.
  • 16 Bai, Y.R., Wu, G.H., Guo, W.J. (2003). Intensity modulated radiation therapy and chemotherapy for locally advanced pancreatic cancer: results of feasibility study. World Journal of Gastroenterol, 9(11), 2561-2564.
  • 17 Orlandi, E., Palazzi, M., Pignoli, E., Fallai, C., Giostra, A., Olmi, P. (2010). Radiobiological basis and clinical results of the simultaneous integrated boost (SIB) in intensity modulated radiotherapy (IMRT) for head and neck cancer. Critical Reviews in Oncology Hematol, 73(2), 111-125.
  • 18 Li, J.G., Xing, L., Boyer, A.L., Hamilton, R.J., Spelbring, D.R., Turian, J.V. (1999). Matching photon and electron fields with dynamic intensity modulation. Medical Physics, 26(11), 2379-2384.
  • 19 Radiation Therapy Oncology Group (RTOG), http://www.rtog.org/ClinicalTrials/ProtocolTable/StudyDetails.aspx, (16.05.2012).
  • 20 Schelegel, W., Bortfeld, T., Grosu, A.L. (2006). New Technoligies in Radiation Oncology. Springer (ed.), 1. baskı, Verlag, Berlin.
  • 21 Van’t Riet, A., Mak, A.C., Moerland, M.A. (1997). A conformation number to quantify the degree of conformality in brachytherapy and external beam irradiation: Application to the prostate. International Journal of Radiation Oncology Biology Physics, 37, 731–736.
  • 22 Krishnan, J., Rao, S., Hedge, S., Shetty, J., Shambhavi. (2015). A Dosimetric Comparison of Double Arc Volumetric Modulated Arc Therapy with Large Field Intensity Modulated Radiation Therapy for Head and Neck Cancer. International Journal of Medical Physics, 4, 353-363.
  • 23 Boylan, C., Rowbottom, C. (2014). A bias-free, automated planning tool for technique comparison in radiotherapy–application to nasopharyngeal carcinoma treatments. Journal of Applied Clinical Medical Physics, 15(1), 213-225.
  • 24 Syam Kumar, S.A., Vivekanandan, N., Sriram, P. (2012). A study on conventional IMRT and RapidArc treatment planning techniques for head and neck cancers. ScienceDirect, 17, 168-175.
  • 25 White, P., Chan, K.C., Cheng, K.W., Chan, K.Y., Chau, M.C. (2013). Volumetric intensity-modulated arc therapy vs conventional intensity-modulated radiation therapy in nasopharyngeal carcinoma: a dosimetric study. Journal of Radiation Research, 54, 532-545.

Baş Boyun Radyoterapisinde Farklı Tedavi Teknikleri İle Simultane Integre Boost Yönteminin Karşılaştırılması

Yıl 2017, Cilt: 29 Sayı: 1, 20 - 28, 21.04.2017
https://doi.org/10.7240/marufbd.306338

Öz

Bu
çalışmada, baş boyun kanserlerinin tedavisinde kullanılan yoğunluk ayarlı
radyoterapi ve yoğunluk ayarlı ark terapi tekniklerinin dozimetrik olarak
karşılaştırılması amaçlanmıştır. Planlarda benzer planlama hedefleri ile 33
günlük fraksiyonlarla eş zamanlı olarak hedef hacimlerde farklı doz
seviyelerinin sağlandığı Simultane Integre Boost tekniği
kullanılmıştır.
Planlar, 6 MV
foton enerjisi kullanılarak, anisotropic analitic algoritması ile Eclipse tedavi
planlama bilgisayarında hesaplatılmıştır.
9 Alan YART ve 2 Ark YAAT
planlarının doz homojenitesi ve doz konformalitesi açısından daha üstün
oldukları görülmektedir. Kritik organların doz değerleri incelendiğinde optik
sinirler, kiazma, gözler, lensler ve parotisler için en düşük dozlar 7 ve 9
Alan YART planları ile elde edilirken beyin sapı, spinal kord, mandibula ve
larenks için en iyi dozlar 2 Ark YAAT planları ile elde edilmiştir. Oral kavite
dozu 1 Ark YAAT planları ile önemli ölçüde azaltılabilmektedir. Normal dokuda
yüksek doz alan hacim değerleri ve ortalama normal doku doz değerleri 1 ve 2
Ark YAAT planları ile azalırken, normal dokuda düşük doz alan hacim değerleri
azda olsa 1 ve 2 Ark planları ile artış göstermektedir. 1, 2 Ark YAAT ve 7, 9 Alan
YART planları baş boyun kanserlerinde klinik olarak kabul edilebilir tedavi
yöntemleridir. Tedavi süresinin kısalığı ve monitor unit değerlerinin düşük
olması açısından YAAT planları daha avantajlıdır.

Kaynakça

  • 1 Nath, R., Biggs, P.J., Bova, F.J., Ling, C.C., Purdy, J.A., van de Geijn, J., Weinhous, M.S. (1994). SYN45 : AAPM Code of Practice for Radiotherapy Accelerators, Report of AAPM Radiation Therapy Task Group, USA.
  • 2 Edward, C.H., Carlos, A.P., Luther, W.B. (2007). Perez and Brady’s Principles and Practice of Radiation Oncology. Lippincott Williams&Wilkins (ed.), 5. baskı, New York, USA.
  • 3 Hall, E.J., Giaccia, A.J. (2006). Radiobiology for the radiologist. Lippincott Williams&Wilkins (ed.), 6. baskı, Philadelphia, USA.
  • 4 Carol, M.P. (1995). A system for planning and rotational delivery of intensity-modulated fields. International journal imaging systems technology, 6, 56-61.
  • 5 Ling, C.C., Burman, C., Chui, C.S. (1996). Conformal radiation treatment of prostate cancer using inversely-planned intensity-modulated photon beams produced with dynamic multileaf collimation. International Journal of Radiation Oncology Biology Physics, 35(4), 721-730.
  • 6 International Commission on Radiation Units and Measurements. (2010). Prescribing, Recording, and Reporting Photon-Beam Intensity-Modulated Radiation Therapy (IMRT), Oxford University, ICRU Report 83, UK.
  • 7 Carol, M.P., Targovnik, H., Smith, D. (1992). 3-D planning and delivery system for optimized conformal therapy. International Journal of Radiation Oncology Biology Physics, 24, 158.
  • 8 Mundt, A.J., Roeske, J.C. (2005). Intensity Modulated Radiation Therapy A Clinical Perspective. BC Decker (ed.), 5. baskı, Hamilton, USA.
  • 9 James, D.C., Kian, A. (2010). Radiation Oncology: Rationale, Technique, Results. Mosby Elsevier (ed.), 9. baskı, Philadelphia, USA.
  • 10 Paul, Q.M., Peter, H.R.E., Patrick, J.G. (2009). Principles and Practice of Head and Neck Surgery and Oncology. Informa healthcare (ed.), 2. baskı, New York, USA.
  • 11 Otto, K. (2007). Volumetric modulated arc therapy: IMRT in a single gantry arc. Medical Physics, 35(1), 310. 12 Khan, F.M. (2003). The Physics of Radiation Therapy. Lippincott Williams&Wilkins (ed.), 4. baskı, Philadelphia, USA.
  • 13 Khan, F.M., Gibbons, J.P. (2014). Treatment Planning in Radiation Oncology. Lippincott Williams&Wilkins (ed.), 5. baskı, Philadelphia, USA.
  • 14 Lauve, A., Morris, M., Schmidt-Ullrich, R. (2004). Simultaneous integrated boost intensity-modulated radiotherapy for locally advanced head and neck squamous cell carcinomas: II clinical results. International Journal of Radiation Oncology Biology Physics, 60(2), 374-387.
  • 15 Mohan, R., Wu, Q., Manning, M., Schmidt-Ulrich, R. (2000). Radiobiological considerations in teh design of fractionation strategies for intensity-modulated radiation therapy of head and neck cancers. International Journal of Radiation Oncology Biology Physics, 46(3), 619-630.
  • 16 Bai, Y.R., Wu, G.H., Guo, W.J. (2003). Intensity modulated radiation therapy and chemotherapy for locally advanced pancreatic cancer: results of feasibility study. World Journal of Gastroenterol, 9(11), 2561-2564.
  • 17 Orlandi, E., Palazzi, M., Pignoli, E., Fallai, C., Giostra, A., Olmi, P. (2010). Radiobiological basis and clinical results of the simultaneous integrated boost (SIB) in intensity modulated radiotherapy (IMRT) for head and neck cancer. Critical Reviews in Oncology Hematol, 73(2), 111-125.
  • 18 Li, J.G., Xing, L., Boyer, A.L., Hamilton, R.J., Spelbring, D.R., Turian, J.V. (1999). Matching photon and electron fields with dynamic intensity modulation. Medical Physics, 26(11), 2379-2384.
  • 19 Radiation Therapy Oncology Group (RTOG), http://www.rtog.org/ClinicalTrials/ProtocolTable/StudyDetails.aspx, (16.05.2012).
  • 20 Schelegel, W., Bortfeld, T., Grosu, A.L. (2006). New Technoligies in Radiation Oncology. Springer (ed.), 1. baskı, Verlag, Berlin.
  • 21 Van’t Riet, A., Mak, A.C., Moerland, M.A. (1997). A conformation number to quantify the degree of conformality in brachytherapy and external beam irradiation: Application to the prostate. International Journal of Radiation Oncology Biology Physics, 37, 731–736.
  • 22 Krishnan, J., Rao, S., Hedge, S., Shetty, J., Shambhavi. (2015). A Dosimetric Comparison of Double Arc Volumetric Modulated Arc Therapy with Large Field Intensity Modulated Radiation Therapy for Head and Neck Cancer. International Journal of Medical Physics, 4, 353-363.
  • 23 Boylan, C., Rowbottom, C. (2014). A bias-free, automated planning tool for technique comparison in radiotherapy–application to nasopharyngeal carcinoma treatments. Journal of Applied Clinical Medical Physics, 15(1), 213-225.
  • 24 Syam Kumar, S.A., Vivekanandan, N., Sriram, P. (2012). A study on conventional IMRT and RapidArc treatment planning techniques for head and neck cancers. ScienceDirect, 17, 168-175.
  • 25 White, P., Chan, K.C., Cheng, K.W., Chan, K.Y., Chau, M.C. (2013). Volumetric intensity-modulated arc therapy vs conventional intensity-modulated radiation therapy in nasopharyngeal carcinoma: a dosimetric study. Journal of Radiation Research, 54, 532-545.
Toplam 24 adet kaynakça vardır.

Ayrıntılar

Konular Mühendislik
Bölüm Araştırma Makaleleri
Yazarlar

Bilgehan Çoşkun

Ayşe Yumak Yahşi

Ayşe Okumuş Bu kişi benim

Şahin Aktaş

Fusun Tokatlı Bu kişi benim

Yayımlanma Tarihi 21 Nisan 2017
Kabul Tarihi 20 Şubat 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 29 Sayı: 1

Kaynak Göster

APA Çoşkun, B., Yahşi, A. Y., Okumuş, A., Aktaş, Ş., vd. (2017). Baş Boyun Radyoterapisinde Farklı Tedavi Teknikleri İle Simultane Integre Boost Yönteminin Karşılaştırılması. Marmara Fen Bilimleri Dergisi, 29(1), 20-28. https://doi.org/10.7240/marufbd.306338
AMA Çoşkun B, Yahşi AY, Okumuş A, Aktaş Ş, Tokatlı F. Baş Boyun Radyoterapisinde Farklı Tedavi Teknikleri İle Simultane Integre Boost Yönteminin Karşılaştırılması. MFBD. Nisan 2017;29(1):20-28. doi:10.7240/marufbd.306338
Chicago Çoşkun, Bilgehan, Ayşe Yumak Yahşi, Ayşe Okumuş, Şahin Aktaş, ve Fusun Tokatlı. “Baş Boyun Radyoterapisinde Farklı Tedavi Teknikleri İle Simultane Integre Boost Yönteminin Karşılaştırılması”. Marmara Fen Bilimleri Dergisi 29, sy. 1 (Nisan 2017): 20-28. https://doi.org/10.7240/marufbd.306338.
EndNote Çoşkun B, Yahşi AY, Okumuş A, Aktaş Ş, Tokatlı F (01 Nisan 2017) Baş Boyun Radyoterapisinde Farklı Tedavi Teknikleri İle Simultane Integre Boost Yönteminin Karşılaştırılması. Marmara Fen Bilimleri Dergisi 29 1 20–28.
IEEE B. Çoşkun, A. Y. Yahşi, A. Okumuş, Ş. Aktaş, ve F. Tokatlı, “Baş Boyun Radyoterapisinde Farklı Tedavi Teknikleri İle Simultane Integre Boost Yönteminin Karşılaştırılması”, MFBD, c. 29, sy. 1, ss. 20–28, 2017, doi: 10.7240/marufbd.306338.
ISNAD Çoşkun, Bilgehan vd. “Baş Boyun Radyoterapisinde Farklı Tedavi Teknikleri İle Simultane Integre Boost Yönteminin Karşılaştırılması”. Marmara Fen Bilimleri Dergisi 29/1 (Nisan 2017), 20-28. https://doi.org/10.7240/marufbd.306338.
JAMA Çoşkun B, Yahşi AY, Okumuş A, Aktaş Ş, Tokatlı F. Baş Boyun Radyoterapisinde Farklı Tedavi Teknikleri İle Simultane Integre Boost Yönteminin Karşılaştırılması. MFBD. 2017;29:20–28.
MLA Çoşkun, Bilgehan vd. “Baş Boyun Radyoterapisinde Farklı Tedavi Teknikleri İle Simultane Integre Boost Yönteminin Karşılaştırılması”. Marmara Fen Bilimleri Dergisi, c. 29, sy. 1, 2017, ss. 20-28, doi:10.7240/marufbd.306338.
Vancouver Çoşkun B, Yahşi AY, Okumuş A, Aktaş Ş, Tokatlı F. Baş Boyun Radyoterapisinde Farklı Tedavi Teknikleri İle Simultane Integre Boost Yönteminin Karşılaştırılması. MFBD. 2017;29(1):20-8.

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