Thyroid hormones and BMI in obese children: One year follow up results

Yıl 2015, Cilt: 28 Sayı: 3, 129 - 134, 28.11.2015

Ferhat Ekinci Arzu Uzuner Merder Demet Bilge Turgut Niyazi Tosun

https://doi.org/10.5472/MMJoa.2803.02

Cited By: 2

Öz

Amaç: Bu çalışmanın amacı tiroid hormon düzeyleri ile obezite,
lipid düzeyleri ve ağırlık değişiklikleri arasındaki ilişkiyi
araştırmaktır.
Hastalar ve Yöntemler: Beş ve onbir yaş aralığında
normal, fazla kilolu ve obez çocukların TSH, sT4, lipid profili ve
otoimmün antikor değerlerine bakılmıştır. TSH düzeyi yüksek olan
çocuklar herhangi bir müdahale yapılmadan bir yıl sonra yeniden
değerlendirilmiştir.
Bulgular: Çalışmada 300 çocuk (126 obez, 74 fazla kilolu,
100 normal kilolu) değerlendirilmiştir. Yüksek TSH düzeyi sıklığı
normal kilolu grupta %1.0, fazla kilolu grupta %9.5 ve obez grupta
%11.9’dur (p=0.007). Bütün gruplarda sT4 düzeyleri normal
bulunmuştur. Çocukların hiçbirinde otoimmun antikorlar pozitif
değildir. Yüksek TSH’lı çocuklar normal TSH’lı çocuklara göre
daha yüksek trigliserid düzeylerine sahiptir (p=0.028). Bir yıl sonra
yapılan değerlendirmede, VKİ’de anlamlı düşüşle birlikte TSH
düzeyinde de anlamlı bir düşüş saptanmıştır.
Sonuç: TSH düzeyleri obez ve fazla kilolu çocuklarda yüksek
olabilir. TSH yüksekliği olan obez ve fazla kilolu çocukların
farmakolojik olarak tedavi edilmesine gerek yoktur, kilo vermek
TSH düzeylerinin anlamlı olarak azalmasını sağlar.

Anahtar Kelimeler

TSH, VKİ, Çocuk, Obezite, Fazla kilolu, Tiroid

Kaynakça

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