Subklinik hipotiroidide aort elastisitesinin değerlendirilmesi

Yıl 2015, Cilt: 28 Sayı: 3, 135 - 141, 28.11.2015

Sevil Özkan Mehmet Tarım Refik Demirtunç Dursun Duman

https://doi.org/10.5472/MMJoa.2803.03

Öz

Amaç: Bu çalışmada. subklinik hipotiroidili hastalarda aortun
elastikiyet özellikleri ve bunların sol ventrikül diyastolik
fonksiyonu ile ilişkileri transtorasik ekokardiyografik metod ile
araştırıldı.
Hastalar ve Yöntemler: Transtorasik ekokardiyografi
yapılarak aortun elastikiyet parametreleri olarak aortik strain. beta
indeksi ve distensibilite indeksine bakıldı.
Bulgular: Kontrol grubu ve subklinik hipotiroidili hasta grubu
arasında aortik strain (sırasıyla %9.45’e karşı %5.79. p < 0.001)
ve distensibilite (4.64’e karşı 3.02 10-3.cm2.dyn-1. p < 0.005)
yönünden anlamlı farklar vardı. Subklinik hipotiroidi grubunda
mitral erken diyastolik akım hızı (E) ortalaması (p < 0.05). mitral
diyastolik akım hızı/ mitral geç diyastolik akım hızı (E/A) (p < 0.01)
kontrol grubu ortalamasına göre anlamlı olarak düşük. mitral geç
diyastolik akım hızı ortalaması (A) ve izovolümetrik relaksasyon
zamanı ( IVRZ) (p < 0.05) kontrol grubu ortalamasına göre yüksek
bulundu.
Sonuç: Subklinik hipotiroidili hastalarda aortik stiffness’de
artış gözlenmektedir. Subklinik hipotiroidili hastalarda gözlenen
diyastolik fonksiyon bozukluğundan esas olarak aortik stiffness
artışı sorumlu olabilir.

Anahtar Kelimeler

Aortik stiffness. Subklinik hipotiroidizm. Sol ventrikül diyastolik disfonksiyonu

The evaluation of aortic elasticity in subclinical hypothyroidism

Öz

Objective: In this study we evaluated the elastic properties of
the aorta in patients with subclinical hypothyroidism and their
relation with left ventricular diastolic function by transthoracic
echocardiography.
Patients and Methods: Aortic transthoracic echocardiography
was performed and the aortic elasticity was evaluated using the
following parameters; strain, the beta index and distensibility.
Results: There was significant difference in terms of aortic
strain (5.79% vs. 9.45% p <0.001) and distensibility (4.64 versus
3.02 10-3.cm2. dyn-1. p <0.005) between the control group and
patients with subclinical hypothyroidism group. In the subclinical
hypothyroidism group the average mitral early diastolic velocity
(E). (p <0.05) were significantly lower than the mean mitral
diastolic flow velocity / mitral late diastolic flow velocity (E / A)
(p <0.01) observed in the control group. and higher than the mean
mitral late diastolic flow velocity (A) and isovolumetric relaxation
time (IVRT) (P <0.05) in the control group.
Conclusions: In patients with subclinical hypothyroidism
an increase in the aortic stiffness was observed. The diastolic
dysfunction observed in subclinical hypothyroidism is mainly
responsible for the increase in the aortic stiffness.
Keywords: Aortic stiffness. Subclinical hypothyroidism. Left
ventricular diastolic dysfunction

Anahtar Kelimeler

Aortic stiffness, Subclinical hypothyroidism, Left ventricular diastolic dysfunction

Kaynakça

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