Synthesis and larvicidal and adult topical activity of some hydrazide-hydrazone derivatives against Aedes aegypti

Yıl 2014, Cilt: 18 Sayı: 3, 120 - 125, 12.09.2014

Kadriye Akdağ Bedia Kocyıgıt-kaymakcıoglu Bedia Koçyiğit-kaymakcıoğlu Nurhayat Tabanca Abbas Ali Alden Estep James J. Becnel James Becnel Ikhlas Khan

Öz

A series of novel hydrazide-hydrazone derivatives were

synthesized and evaluated for their larvicidal and adult

topical activity against Aedes aegypti. The proposed

structures of all the synthesized compounds were confirmed

using elemental analysis, UV, IR, 1H-NMR, 13C-NMR and

mass spectroscopy. Compounds 4a-h were screened in larval

bioassays at concentrations of 100, 50 and 25 ppm in a dose

dependent manner and data for their mortality was recorded.

Among the tested compounds, 1-(4-nitrophenyl)-3-(4-{2-

oxo-2-[2-(2-oxo-1,2-dihydro-3H-ylidene)hydrazinyl] ethyl}

phenyl)urea (4b) showed noteworthy larvacidal activity

against Aedes aegypti. Dose-response data of compound 4b

showed LC50 and LC90 values of 30.5 (15.4 – 22.7) and 95.9

(73.8 – 139.4) ppm, respectively. Screening of compounds

4a-h at four doses by topical bioassay indicated a range of

activity between 10000 and 1000 ppm.

Keywords: Hydrazide-hydrazone, mosquito control, Aedes

aegypti, larvicidal activity, adult topical activity

Anahtar Kelimeler

Hydrazide-hydrazone, mosquito control, Aedes aegypti, larvicidal activity, adult topical activity

Bazı Hidrazit-Hidrazon Türevlerinin Sentezi ve Larvasidal Etkileri

Öz

Bir seri hidrazit-hidrazon türevi bileşik sentezlenmiş ve
bunların larvisidal ve yüzeyel etkisi Aedes aegypti türüne
karşı ölçülmüştür. Sentezlenen tüm bileşiklerin yapıları
elementel analiz, UV, IR, 1H-NMR, 13C-NMR ve kütle
spektroskopisi kullanılarak doğrulanmıştır. 4a-h
bileşiklerinin biyolojik analizleri 100, 50 and 25 ppm
konsantrasyonlarında taranmış ve mortalite oranları
kaydedilmiştir. Test edilen bileşikler arasında 1-(4-nitrofenil)-
3-(4-{2-okso-2-[2-(2-okso-1,2-dihidro-3H-iliden)hidrazinil]
etil} fenil)üre (4b) Aedes aegypti türüne karşı kaydadeğer
larvisidal aktivite göstermiştir. 4b bileşiğinin doz yanıt
verileri, LC50 ve LC90 değerlerini sırasıyla 30.5 (15.4 – 22.7)
ve 95.9 (73.8 – 139.4) ppm olarak göstermiştir. Taranan 4a-h
bileşiklerinin dört dozla yapılan biyolojik analizinde aktivite
aralığının 10000 ve 1000 ppm arasında olduğu belirlenmiştir.

Anahtar Kelimeler

Hidrazit-hidrazon, sivrisinek kontrolü, Aedes aegypti, larvasidal etki, yüzeyel etkinlik

Kaynakça

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