Enhancement of solubility and dissolution of ibuprofen microparticle prepared by ultrasonic spray drying

Yıl 2017, Cilt: 21 Sayı: 4, 783 - 792, 01.12.2017

Revika Rachmanıar Camellia Panataranı İ Made Jonı Marline Abdasah Taofik Rusdıana

Öz

Ibuprofen (IBU) is one of the most commonly used nonsteroidal

anti-inflammatory drugs with high permeability

and low solubility. The aims of this research is to improve the

solubility and dissolution of the IBU by reducing particle size

using ultrasonic spray drying method and utilizing watersoluble

polymer (polyvinyl alcohol (PVA)) and surfactant

(sodium lauryl sulphate (SLS)) for particles formulation. The

results showed that increasing amount of PVA, smaller particle

size of as-prepared IBU-PVA-SLS was obtained, 6.3-fold smaller

than untreated IBU. The in vitro drug release study for simulated

gastric fluid without enzymes (0.1 N HCl or Buffer pH 1.2)

shows the dissolution of prepared IBU-PVA-SLS significantly

increase 2.4-fold higher than untreated IBU for dissolution

time of 30 minutes. While the solubility of the IBU-PVA-SLS

was increased 4.7-fold compare to untreated IBU. In general,

IBU possessing relatively high dissolution in intestinal fluid. In

contrast, the finding of recent investigation on dissolution of

IBU-PVA-SLS is significantly increase in gastric fluid, either due

to smaller particles size or PVA-SLS. Thus, despite the PVA and

SLS determine the particles formation during polymerization

yielding smaller particle size, they also responsible for effective

drug delivery system. It was concluded that PVA and SLS

in ultrasonic spray drying technique for IBU preparation

successfully reduces the particle size and effectively enhances

the solubility and dissolution rate of poorly water-soluble IBU

in 0.1 N HCl.

Anahtar Kelimeler

Ultrasonic spray drying, ibuprofen, polyvinyl alcohol, sodium lauryl sulphate, solubility, dissolution

Kaynakça

• 1. Xu L, Li, S.M, Sunada, H. Preparation and evaluation of ibuprofen solid dispersion systems with kollidon particles using a pulse combustion dryer system. Chem Pharm Bull 2007;55:1545–50.
• 2. Rashid A, White ET, Howes T, Litster JD, Marziano I. Growth rates of ibuprofen crystals grown from ethanol. Proc Chemeca, Flash Drive, Adelaide, 2010.
• 3. Kawabata Y, Wada K, Nakatani M, Yamada S, Onoue S. Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: basic approaches and practical applications. Int J Pharm 2011;420:1–10.
• 4. Wong SM, Kellaway IW, Murdan S. Enhancement of the dissolution rate and oral absorption of a poorly water soluble drug by formation of surfactant-containing microparticles. Int J Pharm 2006;317:61–8.
• 5. Macarron R. Critical review of the role of HTS in drug discovery. Drug Discov Today 2006;11:277–9.
• 6. Mauludin R, Müller RH. Physicochemical properties of hesperidin nanocrystal. Int J Pharm Pharm Sci 2013;5:954-60.
• 7. Siswandi S, Rusdiana T, Levita J. Virtual screening of coformers for ketoprofen co-crystallization and the molecular properties of the co-crystal. J App Pharm Sci 2015;5:78-82.
• 8. Kesisoglou F, Panmai S, Wu Y. Nanosizing-oral formulation development and biopharmaceutical evaluation. Adv Drug Deliv Rev 2007;59:631–44.
• 9. Woo JS, Piao MG, Li DX, Ryu DS, Choi JY, Kim JA, Kim JH, Jin SG, Kim DD, Lyoo WS, Yong CS, Choi HG. Development of cyclosporin A-loaded hyaluronic microsphere with enhanced oral bioavailability. Int J Pharm 2007;345:134–41.
• 10. Re MI. Formulating drug delivery systems by spray drying. Drying Technol 2006;24:433–46.
• 11. Vehring R. Pharmaceutical particle engineering via spray drying. Pharm Res 2008;25:999–1022.
• 12. Heng D, Lee SH, Nga WK, Tan RB. The nano spray dryer B-90. Expert Opin Drug Deliv 2011;8:965–72.
• 13. Fontana MC, Durli TL, Pohlmann AR, Guterres SS, Beck RCR. Polymeric controlled release inhalable powder produced by vibrational spray-drying: One-step preparation and in vitro lung deposition. Powder Technol 2014;258:49–59.
• 14. Draheim C, De Crécy F, Hansen S, Collnot EM, Lehr CM. A design of experiment study of nanoprecipitation and nano spray drying as processes to prepare PLGA nano- and microparticles with defined sizes and size distributions. Pharm Res 2015;32:2609-24.
• 15. Kim JS, Kim MS, Park HJ, Jin SJ, Lee S, Hwang SJ. Physicochemical properties and oral bioavailability of amorphous atorvastatin hemi-calcium using spray-drying and SAS process. Int J Pharm 2008;359:211–9.
• 16. Chow AH, Tong HH, Chattopadhyay P, Shekunov BY. Particle engineering for pulmonary drug delivery. Pharm Res 2007;24:411-37.
• 17. Buttini F, Colombo P, Rossi A, Sonvico F, Colombo G. Particles and powders: Tools of innovation for noninvasive drug administration. J Control Release 2012;161:693-702.
• 18. Belotti S, Rossi A, Colombo P, Bettini R, Rekkas D, Politis S, sulphate powder for inhalation in cystic fibrosis patients: The role of ethanol in particle formation. Eur J Pharm Biopharm 2015;93:165-72.
• 19. Pyo SH, Cho JS, Choi HJ, Han BH. Preparation and dissolution profiles of the amorphous, dihydrated crystalline, and anhydrous crystalline forms of paclitaxel. Dry Technol 2007;25:1759–67.
• 20. Puri V, Dantuluri AK, Kumar M, Karar N, Bansal AK. Wettability and surface chemistry of crystalline and amorphous forms of a poorly water soluble drug. Eur J Pharm Sci 2010;40:84–93.
• 21. Hen S, Nga WK, Chia L, Hu J, Tan RB. Physical state and dissolution of ibuprofen formulated by co-spray drying with mesoporous silica: effect of pore and particle size. Int J Pharm 2011;410:188–95.
• 22. Duret C, Wauthoz N, Sebti T, Vanderbist F, Amighi K. New respirable and fast dissolving itraconazole dry powder composition for the treatment of invasive pulmonary aspergillosis. Pharm Res 2012;29:2845–59.
• 23. Bianco S, Caron V, Tajber L, Corrigan OI, Nolan L, Hu Y, Healy AM. Modification of the solid-state nature of sulfathiazole and sulfathiazole sodium by spray drying. AAPS Pharm Sci Tech 2012;13:647–60.
• 24. Li DX, Oh YK, Lim SJ, Kim JO, Yang HJ, Sung JH, Yong CS, Choi HG. Novel gelatin microcapsule with bioavailability enhancement of ibuprofen using spray-drying technique. Int J Pharm 2008;355:277–84.
• 25. Lee EJ, Lee SW, Choi HG, Kim CK. Bioavailability of cyclosporin A dispersed in sodium lauryl sulphate–dextrin based solid microspheres. Int J Pharm 2001;218:125–31.
• 26. Panatarani C, Lenggoro IW, Okuyama K. The crystallinity and the photoluminescent properties of spray pyrolized ZnO phosphor containing Eu2+ and Eu3+ ions. J Phys Chem Solids 2004;65:1843-7.
• 27. Pasquali I, Bettini R, Giordano F. Solid-state chemistry and particle engineering with supercritical fluids in pharmaceutics. Eur J Pharm Sci 2006;27:299–310.
• 28. Panatarani C, Lenggoro IW, Okuyama K. Synthesis of single crystalline ZnO nanoparticles bysalt-assisted spray pyrolysis. J Nano Res 2003;5:47-53.
• 29. Alver U, Kılınç T, Bacaksız E, Küçükömeroğlu T, Nezir S, Mutlu IH, Aslan F. Synthesis and characterization of spray pyrolysis zinc oxide microrods. Thin Solid Films 2007;515:3448–51.
• 30. Joni IM, Panatarani C, Hidayat D, Setianto, Wibawa BW, Rianto A, Thamrin H. Synthesis and dispersion of nanoparticles, and Indonesian graphite processing. AIP Conf Proc 2013;1554:20- 6.
• 31. Hancock BC, Zografi G. Characteristics and significance of the amorphous state in pharmaceutical systems. J Pharm Sci 1997;86:1-12.
• 32. Supratman, U. Spektrometri Inframerah. In: Elusidasi struktur senyawa organik. Vol 1, First ed. Widya Padjadjaran, Bandung, 2010, pp. 66-106.
• 33. Elkordy AA, Essa EA. Effects of Spray Drying and Spray Chilling on Ibuprofen Dissolution. Iranian J Pharm Sci 2010;6:3-12.
• 34. Mohanraj VJ, Chen Y. Nanoparticles-a review. Trop J Pharm Res. 2006;5(1):561-573.
• 35. Yen F, Wu T, Tzeng C, Lin L, Lin C. Curcumin nanoparticle improve the physicochemical properties of curcumin and effectively enhance its antioxidant and antihepatoma activities. J Agric Food Chem 2010;58:7376-82.