Alkaloid profiling of Galanthus woronowii Losinsk. by GC-MS and evaluation of its biological activity

Yıl 2017, Cilt: 21 Sayı: 4, 915 - 920, 01.12.2017

Buket Bozkurt Ahmet Emir Gülen İrem Kaya Mustafa Ali Önür Strahil Berkov Jaume Bastida Nehir Ünver Somer

Öz

The alkaloid profiles of the aerial parts and the bulbs of

Galanthus woronowii Losinsk. were analyzed by means of Gas

Chromatography-Mass Spectrometry (GC-MS). Totally, twentyeight

compounds were detected. Galanthamine and galanthine

were found to be the main alkaloids both in the extracts of the

aerial parts and the bulbs. Most of the identified compounds

were lycorine and galanthamine-type Amaryllidaceae alkaloids.

In addition, the acetylcholinesterase (AChE) inhibitor potentials

of the extracts prepared from the aerial parts and bulbs were

determined by in vitro Ellman’s method and both of the extracts

were found to exhibit significant activity (aerial parts: IC50=

0.027 μg/mL and bulbs: IC50= 0.084 μg/mL).

Anahtar Kelimeler

Galanthus woronowii; Amaryllidaceae; GC-MS; alkaloids.

Kaynakça

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