An Inappropriate ADH Syndrome and Lung Cancer Diagnosis in A Patient with Isolated Hyponatremia

Yıl 2018, Cilt: 4 Sayı: 2, 27 - 30, 30.08.2018

Özlem Özdemir Atakan Savrun

https://doi.org/10.19127/mbsjohs.415600

Öz

Hyponatremia is generally considered to
have a plasma sodium concentration less than 135 mEq / L.It is the most common
electrolyte abnormality which is important in clinical practice. It can be caused by many etiological
factors. İnappropriate antidiuretic hormone syndrome (SIADH) is the one of the causes of
normovolemic hyponatremia. On the other hand SIADH is responsible for 30% of
hyponatremias due to cancer. It appears as a paraneoplastic syndrome especially
and most offen in the lung carcinoma. The World Health Organization (WHO)
reported that lung cancer is 12.9% of all cancers. It may manifest itself with
specific symptoms, but may also show only the paraneplastic syndrome. Therefore,
it should be kept in mind that the cause of hyponatremia must be determined and
may be a symptom of SIADH and lung cancer.

Anahtar Kelimeler

Hyponatremia, inappropriate antidiuretic hormone syndrome, lung cancer

Kaynakça

• Adrogué HJ, Madias NE. Hyponatremia. N Engl J Med 2000; 342: 1581-9.
• Anderson RJ, Chung HM, Kluge R, Schrier RW. Hyponatremia: a prospective analysis of its epidemiology and the pathogenetic role of vasopressin. Ann Intern Med 1985; 102: 164-8.
• Decaux G, Musch W. Clinical laboratory evaluation of the syndrome of inappropriate secretion of antidiuretic hormone. Clin J Am Soc Nephrol 2008; 3: 1175-84.
• Ellison DH, Berl T. Clinical practice. The syndrome of inappropriate antidiuresis. N Engl J Med 2007; 356: 2064-72.
• Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015; 136(5): E359-86.
• Goksel T, Eser S, Guclu S.Z, Karadag M, Cilli A, Ozlu T. et. al. Prognostic factors affecting survival in cases with lung cancer [A lung cancer mapping project in Turkey (LCMPT)]. European Respiratory Journal. 2013; 42:2920
• Kalemkerian GP, Akerley W, Bogner P, Borghaei H, Chow LQ, Downey RJ, et al.Small cell lung cancer. J Natl Compr Canc Netw 2013; 11(1): 78-98.
• Reddy P, Mooradian AD. Diagnosis and management of hyponatraemia in hospitalised patients. Int J Clin Pract 2009; 63(10): 1494-508.
• Sorensen JB, Andersen MK, Hansen HH. Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in malignant disease. J Intern Med 1995; 238(2): 97-110
• Sterns RH. Disorders of plasma sodium-causes, consequences, and correction. N Engl J Med 2015; 372: 55-65.
• Upadhyay A, Jaber BL, Madias NE. Incidence and prevalence of hyponatremia. Am J Med 2006; 119: 30-5.