Optimal cytoreduction is the only independent prognostic factor for survival in women with ovarian clear cell carcinoma

Yıl 2015, Cilt: 2 Sayı: 6, 345 - 51, 07.09.2015

Ulas Solmaz Emre Mat Atalay Ekin Levent Dereli Özgür Turan Gulsah Demirtas Cenk Gezer Pinar Hasdemir Sevil Sayhan Muzaffer Sanci

Öz

Objective: To evaluate the clinicopathological characteristics, treatment methods, survival, and prognosis of ovarian clear-cell carcinoma (OCCC).

Material and Methods: All patients with OCCC who were treated between January 1998 and October 2012 were retrospectively reviewed. After the exclusion criteria, a total of 39 women were included in the present study. Univariate and multivariate analyses were used to identify the risk factors for overall survival (OS) and progression-free survival (PFS).

Results: The majority of the patients were at stage I disease (n=21 [24.3%]). All patients underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy. Additionally only pelvic, and pelvic plus para-aortic lymphadenectomy was done in 8 (20.5%) and 19 (48.8%) women, respectively. Optimal cytoreductive surgery was achieved in 26 (66.7%) patients. Recurrences occurred in 11 (28.2%) patients. The median follow-up period was 51 months (range 4 – 132 months). The 5-year PFS and OS rates were 47% and 54%, for all patients. The 5-year OS rates for women with early (stage I and II) and advanced (stage III and IV) stage disease were 56.4% and 38.1%, respectively. Multivariate analysis confirmed optimal cytoreduction as the only independent predictor of OS [Odds ratio (OR) 21.212, 95% confidence interval (CI) 5.259–85.556, (p<0.001)]

Conclusion: Optimal cytoreductive surgery is the only independent good prognostic factor for survival in patients with OCCC.

Anahtar Kelimeler

ovarian clear-cell carcinoma, survival, optimal cytoreduction, chemotherapy

Optimal cytoreduction is the only independent prognostic factor for survival in women with ovarian clear cell carcinoma

Öz

Kaynakça

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