Biological evaluation of 2,5-dimethyl-1,4-benzoquinone biotransformation metabolite

Yıl 2017, Cilt: 4 Sayı: 1, 14 - 17, 05.03.2017

Hale Gamze Ağalar Gökalp İşcan Yoshiaki Noma Özlem Atlı Fatih Demirci Neşe Kırımer

Öz

The substrate of this study, 2,5-dimethyl-1,4-benzoquinone (DMBQ), is one of the naturally occurring quinones which is found in
insects as a defence metabolite. In the present study, DMBQ was biotransformed by using the micro-fungus Corynespora cassicola.
The transformation metabolite was initially screened by TLC and GC-MS, then further characterized by NMR (13C- and 1H-NMR)
spectroscopic techniques and was identified as ‘2,5-dimethyl 1,4-benzenediol’. In addition, both the substrate and metabolite was
evaluated for the in vitro anticandidal, and antioxidant properties along with XTT-cytotoxicity.

Anahtar Kelimeler

Benzoquinone, microbial biotransformation, biological activity

Kaynakça

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