Serum Lipid Profile in Patients with Cholelithiasis

Yıl 2019, Cilt: 4 Sayı: 2, 139 - 147, 30.06.2019

Rakesh Pokhrel Parshal Bhandarı Binod Aryal

https://doi.org/10.26453/otjhs.467734

Öz

This research aims to correlate status of lipid
profile in the patients diagnosed with cholelithiasis. It is an observational
case control study, completed in the Biochemistry department of Tribhuvan
University and Teaching Hospital (TUTH). Total 100 subjects were
selected and divided in two groups. The
groups consisted of 50 patients with cholelithiasis (group A) and 50 healthy control groups (group B). The research was completed
within a time of eight months commencing from 1st March 2016 to 31st
October 2016.  Confirmation of
cholelithiasis was performed with ultrasound studies by
radiologist. Selection of group A and group B were done on basis of
radiological findings. Fasting blood samples for lipid profiles of all subjects
were collected and lipid profile tests done in bio-chemistry lab. Self-designed
form was used for documentation of different parameters of subjects. Triglyceride (TG) and
High-Density Lipids (HDL) were found to be statically significant (p=0.005 and
p=0. 001, respectively). Mean TG level in patients with cholelithiasis (1.9
mmol/l) was found higher than in normal cases (1.45 mmol/l). Mean HDL level in
patients (0.95 mmol/l) was lower than normal cases with (1.05mmol/l). In conclusion, we think that lipid profiles altered in
patients with cholelithiasis.

Anahtar Kelimeler

Cholelithiasis, total cholesterol, triglyceride, high density lipid, low density lipid

Kolelitiazisli Hastalarda Serum Lipit Profili

Öz

Bu araştırma, kolelitiazis
tanısı alan hastalarda lipid profili durumunu ilişkilendirmeyi amaçlamaktadır.
Biyokimya Anabilim Dalı'nda tamamlanmış bir gözlemsel vaka kontrol
çalışmasıdır. Toplam 100 denek seçildi ve iki gruba ayrıldı. Gruplar
kolelitiazisli 50 hasta (grup A) ve 50 sağlıklı kontrol gruptan (grup B)
oluşmaktaydı.  Araştırma, 1 Mart 2016 ile
31 Ekim 2016 tarihleri ​​arasında sekiz ay içinde tamamlandı. Kolelitiazisin
doğrulanması Radyolog tarafından ultrason çalışmaları ile gerçekleşmiştir. Grup
A ve grup B seçimi radyolojik bulgulara dayanarak yapıldı. Tüm olguların lipit
profilleri için açlık kan örnekleri toplandı ve lipit profil testleri biyokimya
laboratuarında yapıldı. Olguların farklı parametrelerinin belgelenmesi için
öz-tasarımlı form kullanıldı. Trigliserit (TG) ve Yüksek Yoğunluklu Lipidler
(HDL) istatistiksel olarak anlamlı bulundu. (Sırasıyla, p = 0,005 ve p =
0,001). Safra taşı olan hastalarda ortalama TG seviyesi (1,9 mmol / l) normal
olgulardan (1,45 mmol / l) daha yüksek bulundu. Hastalarda ortalama HDL düzeyi
(0,95 mmol / l) normal olgulardan (1,05 mmol / l) düşüktü. Sonuç olarak
kolelitiazisli hastalarda lipit profillerinin değiştiğini düşünmekteyiz.

Anahtar Kelimeler

Kolelitiazis, total kolesterol, trigliserit, yüksek yoğunluklu lipid, düşük yoğunluklu lipid

Kaynakça

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