Şizofreni Etyolojisinde Mikrobiyotanın Rolü

Yıl 2018, Cilt: 10 Sayı: 2, 265 - 278, 30.06.2018

Şükrü Kartalcı

https://doi.org/10.18863/pgy.358105

Cited By: 1

Öz

Son yıllarda diğer bozukluklarda olduğu gibi şizofreni etyolojisinde de mikrobiyotanın rolü araştırıl-maktadır. Beyin ve bağırsak mikrobiyotası arasında çift yönlü iletişimin olduğu gittikçe artan bir şekilde kabul edilmektedir. Gastrointestinal sistemdeki yapısal hasarlar, enfektif patojenlere ve gıda antijenlerine karşı artmış bağışıklık tepkileri şizofrenide olası mikrobiyotik değişiklikleri gösteren kanıtlardır. Mikrobiyotadaki değişikliklerin şizofreni hastalarındaki metabolik anormalliklere katkıda bulunabileceği ileri sürülmektedir. Bu yazıda, mikrobiyota ve şizofreni bağlantısını inceleyen güncel araştırmalar gözden geçirilmiştir.

Anahtar Kelimeler

Mikrobiyota, bağırsak-beyin ekseni, şizofreni

The Role of Microbiota in the Etiology of Schizophrenia

Öz

In recent years, the role of microbiota in the etiology of schizophrenia has been a focus of investigation. It is now increasingly recognized that bidirectional communication exists between brain and gut microbiota. Evidence that indicate possible microbiota alteration in schizophrenia includes structural damage to the gastrointestinal tract, a heightened immune response to infectious pathogens and food antigens. It is proposed that an altered microbiome may contribute to abnormalities in metabolic function in schizophrenia. The aim of this article is to review recent literature on connection of the microbiota and schizophrenia.

Anahtar Kelimeler

Microbiota, gut-brain axis, schizophrenia

Kaynakça

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