Utilization avenues for induced pluripotent stem cells in autism

Yıl 2019, Cilt: 41 Sayı: 1, 115 - 120, 28.03.2019

Ceymi Doenyas Nelisa Türkoğlu Laçin

https://doi.org/10.7197/223.vi.543431

Öz

Objective: Autism spectrum disorder
(ASD) is a neurodevelopmental difference with increasing global prevalence.
Yet, the etiology of ASD is still not unraveled. Individuals with ASD
experience difficulties with social skills and communication, and exhibit
repetitive and restrictive interests and behaviors.

Method: There is yet no
comprehensive model of autism that can explain all aspects of autism.
Similarly, there exists no known treatment for it. Induced pluripotent stem
cell (iPSC), which has been widely used in the regenerative treatment of many
diseases in recent years, is promising for a better understanding of the causes
of autism.

Results: Autism modelling with
iPSCs provides several opportunities for understanding the mechanisms
underlying autism and developing personalized treatments.

Conclusions: This review
examines the use of iPSCs in ASD to date, their advantages, and the findings
obtained via iPSC modeling of autism.

Anahtar Kelimeler

autism, induced pluripotent stem cell, modelling

Uyarılmış pluripotent kök hücrelerin otizm’de kullanım alanları

Öz

Amaç: Otizm
spektrum bozukluğu, dünya çapında yaygınlığı giderek artan fakat sebepleri hala
tamamen bilinmeyen, nörogelişimsel bir farklılıktır. Otizmli bireyler, sosyal
beceri ve iletişim zorlukları yaşarlar; tekrar eden ve kısıtlayıcı ilgi
alanları ile davranışlar gösterirler. Otizmin bilinen bir tedavisi veya otizmin
bütün unsurlarını açıklayabilen kapsamlı bir model henüz yoktur.

Yöntem: Son
yıllarda birçok hastalığın rejeneratif tedavisinde oldukça yaygın olarak
kullanılan kök hücrelerden, uyarılmış pluripotent kök hücre (UPKH), otizmin
sebeplerinin daha iyi anlaşılması için umut vaat edicidir.

Bulgular: UPKH’ler
ile yürütülen otizm modellemeleri, otizme neden olan mekanizmaların
anlaşılması, bozuklukların düzeltilmesi ve kişiye özel tedavilerin
geliştirilmesi için çeşitli fırsatlar sunmaktadır.

Sonuç:  Bu derleme, UPKH’lerin şu ana kadar otizmdeki
kullanım alanlarını, avantajlarını ve UPKH modellemeleri ile elde edilen
bulguları incelemektedir.

Anahtar Kelimeler

otizm, uyarılmış pluripotent kök hücre, modelleme

Kaynakça

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