Evaluation of Drug-Drug Interactions in Renal Transplant Patients

Yıl 2023, Cilt: 4 Sayı: 3, 292 - 295, 29.11.2023

Rüya Mutluay Sinem Gürcü

Öz

Introduction: The number of patients with chronic renal failure is increasing day by day throughout the world and in our country. It is also known that these patients have increased mortality and morbidity. As a result, the rate of patients requiring renal replacement therapy is also increasing. Renal transplantation is the treatment method that offers the closest standard of living among renal replacement treatments, and it is also known that this group of patients uses many additional medications along with regular immunosuppressive treatment. In this study, we planned to investigate drug-drug interactions in renal transplant patients with multiple drug use.
Methods: Prescriptions of renal transplant patients who applied to the nephrology outpatient clinic between January and December 2022 were analyzed retrospectively.
Results: 94 prescriptions were included in the study. In the study, a total of 21 major, 34 medium, and 144 low-level interactions were detected in 94 prescriptions.
Conclusion: Drug-drug interactions are extremely common in kidney transplant patients. It is important for physicians and pharmacists who follow the patients to be aware of this situation and to question whether each new drug planned to be prescribed causes drug-drug interaction.

Anahtar Kelimeler

Kidney transplantation, Drug interactions, Nephrology

Renal Transplant Hastalarında İlaç-İlaç Etkileşimlerinin Değerlendirilmesi

Öz

Giriş: Dünya genelinde ve ülkemizde kronik böbrek yetmezlikli hasta sayısı her geçen gün artış göstermekte; bu hastaların artmış mortalite ve morbiditesinin olduğu da bilinmektedir. Bunun sonucu olarak renal replasman tedavisine ihtiyaç duyan hasta oranı da artmaktadır. Böbrek nakli renal replasman tedavileri içerisinde en normale yakın yaşam standardı sunan tedavi yöntemi olup bu grup hastanın düzenli immunsupresif tedaviyle birlikte pek çok ek ilaç kullanmakta olduğu da bilinmektedir. Bu çalışmada çoklu ilaç kullanımının olduğu renal transplantlı hastalardaki ilaç-ilaç etkileşimini araştırmayı planladık.
Yöntemler: Ocak - Aralık 2022 tarihleri arasında nefroloji polikliniğine başvuran renal transplant hastalarının reçeteleri geri dönük incelendi.
Bulgular: Çalışmaya 94 reçete dahil edildi. Araştırmada 94 reçetede toplam 21 majör, 34 orta ve 144 düşük seviyeli etkileşim tespit edildi.
Sonuç: Böbrek nakilli hastalarda ilaç-ilaç etkileşimi asımsanmayacak ölçüde sık görülmektedir. Bu durumun hastaları takip eden hekimler ve eczacılar tarafından bilinmesi ve yeni yazılması planlanan her ilacın ilaç-ilaç etkileşimine yol açıp açmadığının sorgulanması önem taşımaktadır.

Anahtar Kelimeler

böbrek nakli, ilaç etkileşimleri, nefroloji

Kaynakça

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