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A Very Rare Relaps Type in Multiple Myeloma: Leptomenıngeal and Cranial Involvement

Yıl 2024, Cilt: 16 Sayı: 1, 28 - 36, 30.04.2024
https://doi.org/10.56484/iamr.1455752

Öz

Multiple myeloma is a hematological malignancy that develops as a result of clonal proliferation of plasma cells and progresses with remissions and relapses. It is clinically characterized by many symptoms and signs such as osteolytic bone lesions, hypercalcemia, renal dysfunction, hypergammaglobulinemia and anemia. However, involvement of the central nervous system, especially the leptomeningeal/cranial region, is a rare and prognostically important form of relapse of the disease. This case report discusses this rare clinical presentation, diagnostic approach, and treatment strategies of extramedullary involvement of multiple myeloma.

Kaynakça

  • Rajkumar SV, Dimopoulos MA, Palumbo A, et al. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol. 2014;15(12):e538-e548.
  • Fonseca R, Barlogie B, Bataille R, et al. Genetics and cytogenetics of multiple myeloma: a workshop report. Cancer Res. 2004;64(4):1546-1558.
  • Hideshima T, Bergsagel PL, Kuehl WM, Anderson KC. Advances in biology of multiple myeloma: clinical applications. Blood. 2004;104(3):607-618.
  • Roodman GD. Pathogenesis of myeloma bone disease. Leukemia. 2009;23(3):435-441.
  • Terpos E, Morgan G, Dimopoulos MA, et al. International Myeloma Working Group recommendations for the treatment of multiple myeloma-related bone disease. J Clin Oncol. 2013;31(18):2347-2357.
  • Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70(1):7-30.
  • Kyle RA, Rajkumar SV. Epidemiology of the plasma-cell disorders. Best Pract Res Clin Haematol. 2007;20(4):637-664.
  • Waxman AJ, Mink PJ, Devesa SS, et al. Racial disparities in incidence and outcome in multiple myeloma: a population-based study. Blood. 2010;116(25):5501-5506.
  • Roodman GD. Pathogenesis of myeloma bone disease. J Clin Oncol. 2009;27(6):968-974.
  • Dimopoulos MA, Kastritis E, Rosinol L, Blade J, Ludwig H. Pathogenesis and treatment of renal failure in multiple myeloma. Leukemia. 2008;22(8):1485-1493.
  • Paiva B, Orfao A, Dongen J. New criteria for response assessment: role of minimal residual disease in multiple myeloma. Blood. 2015
  • Usmani SZ, Heuck C, Mitchell A, et al. Extramedullary disease portends poor prognosis in multiple myeloma and is over-represented in high-risk disease even in the era of novel agents. Haematologica. 2012;97(11):1761-1767.
  • Fassas AB, Ward S, Muwalla F, et al. Myeloma of the central nervous system: strong association with unfavorable chromosomal abnormalities and other high-risk disease features. Leuk Lymphoma. 2004;45(2):291-300.
  • Gozzetti A, Cerase A, Lotti F, et al. Extramedullary intracranial localization of multiple myeloma and treatment with novel agents: a retrospective survey of 50 patients. Cancer. 2012;118(6):1574-1584.
Yıl 2024, Cilt: 16 Sayı: 1, 28 - 36, 30.04.2024
https://doi.org/10.56484/iamr.1455752

Öz

Kaynakça

  • Rajkumar SV, Dimopoulos MA, Palumbo A, et al. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol. 2014;15(12):e538-e548.
  • Fonseca R, Barlogie B, Bataille R, et al. Genetics and cytogenetics of multiple myeloma: a workshop report. Cancer Res. 2004;64(4):1546-1558.
  • Hideshima T, Bergsagel PL, Kuehl WM, Anderson KC. Advances in biology of multiple myeloma: clinical applications. Blood. 2004;104(3):607-618.
  • Roodman GD. Pathogenesis of myeloma bone disease. Leukemia. 2009;23(3):435-441.
  • Terpos E, Morgan G, Dimopoulos MA, et al. International Myeloma Working Group recommendations for the treatment of multiple myeloma-related bone disease. J Clin Oncol. 2013;31(18):2347-2357.
  • Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70(1):7-30.
  • Kyle RA, Rajkumar SV. Epidemiology of the plasma-cell disorders. Best Pract Res Clin Haematol. 2007;20(4):637-664.
  • Waxman AJ, Mink PJ, Devesa SS, et al. Racial disparities in incidence and outcome in multiple myeloma: a population-based study. Blood. 2010;116(25):5501-5506.
  • Roodman GD. Pathogenesis of myeloma bone disease. J Clin Oncol. 2009;27(6):968-974.
  • Dimopoulos MA, Kastritis E, Rosinol L, Blade J, Ludwig H. Pathogenesis and treatment of renal failure in multiple myeloma. Leukemia. 2008;22(8):1485-1493.
  • Paiva B, Orfao A, Dongen J. New criteria for response assessment: role of minimal residual disease in multiple myeloma. Blood. 2015
  • Usmani SZ, Heuck C, Mitchell A, et al. Extramedullary disease portends poor prognosis in multiple myeloma and is over-represented in high-risk disease even in the era of novel agents. Haematologica. 2012;97(11):1761-1767.
  • Fassas AB, Ward S, Muwalla F, et al. Myeloma of the central nervous system: strong association with unfavorable chromosomal abnormalities and other high-risk disease features. Leuk Lymphoma. 2004;45(2):291-300.
  • Gozzetti A, Cerase A, Lotti F, et al. Extramedullary intracranial localization of multiple myeloma and treatment with novel agents: a retrospective survey of 50 patients. Cancer. 2012;118(6):1574-1584.
Toplam 14 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Hematoloji
Bölüm Case Report
Yazarlar

Orhan Ayyıldız 0000-0001-5673-8408

Songül Beskisiz 0000-0001-9893-3586

Yayımlanma Tarihi 30 Nisan 2024
Gönderilme Tarihi 19 Mart 2024
Kabul Tarihi 26 Nisan 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 16 Sayı: 1

Kaynak Göster

APA Ayyıldız, O., & Beskisiz, S. (2024). A Very Rare Relaps Type in Multiple Myeloma: Leptomenıngeal and Cranial Involvement. International Archives of Medical Research, 16(1), 28-36. https://doi.org/10.56484/iamr.1455752
AMA Ayyıldız O, Beskisiz S. A Very Rare Relaps Type in Multiple Myeloma: Leptomenıngeal and Cranial Involvement. IAMR. Nisan 2024;16(1):28-36. doi:10.56484/iamr.1455752
Chicago Ayyıldız, Orhan, ve Songül Beskisiz. “A Very Rare Relaps Type in Multiple Myeloma: Leptomenıngeal and Cranial Involvement”. International Archives of Medical Research 16, sy. 1 (Nisan 2024): 28-36. https://doi.org/10.56484/iamr.1455752.
EndNote Ayyıldız O, Beskisiz S (01 Nisan 2024) A Very Rare Relaps Type in Multiple Myeloma: Leptomenıngeal and Cranial Involvement. International Archives of Medical Research 16 1 28–36.
IEEE O. Ayyıldız ve S. Beskisiz, “A Very Rare Relaps Type in Multiple Myeloma: Leptomenıngeal and Cranial Involvement”, IAMR, c. 16, sy. 1, ss. 28–36, 2024, doi: 10.56484/iamr.1455752.
ISNAD Ayyıldız, Orhan - Beskisiz, Songül. “A Very Rare Relaps Type in Multiple Myeloma: Leptomenıngeal and Cranial Involvement”. International Archives of Medical Research 16/1 (Nisan 2024), 28-36. https://doi.org/10.56484/iamr.1455752.
JAMA Ayyıldız O, Beskisiz S. A Very Rare Relaps Type in Multiple Myeloma: Leptomenıngeal and Cranial Involvement. IAMR. 2024;16:28–36.
MLA Ayyıldız, Orhan ve Songül Beskisiz. “A Very Rare Relaps Type in Multiple Myeloma: Leptomenıngeal and Cranial Involvement”. International Archives of Medical Research, c. 16, sy. 1, 2024, ss. 28-36, doi:10.56484/iamr.1455752.
Vancouver Ayyıldız O, Beskisiz S. A Very Rare Relaps Type in Multiple Myeloma: Leptomenıngeal and Cranial Involvement. IAMR. 2024;16(1):28-36.

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