The Effects of Corona Stimulation on the Osseointegration of Dental Implants: An Experimental Study

Yıl 2024, Cilt: 6 Sayı: 1, 1 - 7, 31.01.2024

Mustafa Ayhan Hümeyra Kocaelli

https://doi.org/10.37990/medr.1365954

Öz

Aim: Currently, one of the most promising research areas in dental implantology is the exploration of additional procedures to reduce loading time for implants and enhance osseointegration in cases of poor bone quality. Various techniques have been researched and developed for stimulating bone production, including electrical stimulation of the jawbone and surrounding tissues. However, there is limited research on the direct relationship between electrostimulation and osseointegration. This experimental study aims to investigate the effects of corona stimulation (CS) on the rate and quality of osseointegration, as well as its potential to reduce the waiting period for dental implants.
Material and Method: In this experimental protocol, 32 dental implants were inserted into the tibia of four male sheep bilaterally. Implants on the right tibia of each male sheep underwent CS treatment, while the other side served as a control group without any stimulation. The animals were sacrificed on the 15th and 30th days after implantation. Bone segments containing the implants were processed using a noncalcified method. It assessed new bone formation and osseointegration around the dental implants using the undecalcified method and histomorphological analysis. An experienced blinded investigator measured percentages of mineralized bone-implant contact (BIC), bone area (BAr), and bone perimeter (BPm) to evaluate the bone-implant interface. Statistical analyses were performed using SPSS 21 for Windows, with a significance level set at p<0.05.
Results: The histomorphometric parameters revealed a significant increase in BIC, BAr, and BPm values in the CS group compared to the control group on both the 15th and 30th days (p<0.05). There was no statistically significant difference in BIC ratio between the second and fourth stimulation groups.
Conclusion: The findings of this experimental study suggest that CS may have a positive impact on the early osseointegration period of dental implants.

Anahtar Kelimeler

corona stimulation, dental implant, electrostimulation, histomorphometry, osseointegration

Etik Beyan

The experimental protocol commenced following approval from the İstanbul University Animal Experiments Local Ethics Committee, under the reference number 2014/77, on July 18, 2014.

Destekleyen Kurum

Funding for this study was provided by the Scientific Research Project Unit of İstanbul University (BAP project no. 49665). The implants utilized in this research were sourced from Zimmer® (USA).

Proje Numarası

BAP project no. 49665

Kaynakça

• Brånemark PI. Osseointegration and its experimental background. J Prosthet Dent. 1983;50:399-410.
• Albrektsson T. The response of bone to titanium implants. CRC Crit Rev Biocompatibility. 1985;1:53-84.
• Adell R, Eriksson B, Lekholm U, et al. Longterm follow-up study of osseointegrated implants in the treatment of totally edentulous jaws. Int J Oral Maxillofac Implants. 1990;5:347-59.
• Parithimarkalaignan S, Padmanabhan TV. Osseointegration: an update. J Indian Prosthodont Soc. 2013;13:2-6.
• Albrektsson T. Oral implant surfaces: Part 1- Review focusing on topographic and chemical properties of different surfaces and in vivo responses to them. Int J Prosthodont. 2004;17:536-43.
• Al-Saadi G, Quirynen M, Komérk A, van Steenberghe D. Impact of local and systemic factors on incidence of late oral implant loss. Clin Oral Implants Res. 2008;19:670-6.
• Brechter M, Nilson H, Lundgren S. Oxidised titanium implants in reconstructive jaw surgery. Clin Implant Dent Relat Res. 2005;7:83-7.
• Cook JJ, Summers NJ, Cook EA. Healing in the new milennium: bone stimulators. An overview of where we have been and where we may be heading. Clin Podiatr Med Surg. 2005;32:45-59.
• Shayesteh YS, Eslami B, Dehghan MM, et al. The effect vvof a cocnstant electrical field on osseointegration after immediate implantation in dog mandibles: a preliminary study. J Prosthodont. 2007;16:337-42.
• Shigvcino T, Ochi M, Kagami H, et al. Application of capacitevely coupled electric field enhances periimplant osteogenesis in the dog cmandible. Int J Prosthodont. 2000;13:365-72.
• Black RR. Use of transcutaneous electrical nerve stimulation in dentistry. J Am Dent Assoc. 1986;113:649-52.
• Kasat V, Gupta A, Ladda R, et al. Transcutaneus electric nerve stimulation (TENS) in dentistry- A review. J Clin Exp Dent. 2014;6:562-8.
• Rajendran SB, Challen K, Wright KL, Hardy JG. Electrical stimulation to enhance wound healing. J Funct Biomater. 2021;12:40.
• Jha AK, Gupta S, Sinha A, et al. Efficacy of two types of noninvasive nerve stimulation in the management of myofascial pain caused by Temporomandibular Joint (TMJ) disorders. Cureus. 2023;27;15:e42584.
• Bhavsar MB, Han Z, DeCoster T, et al. Electrical stimulation-based bone fracture treatment, if it works so well why do not more surgeons use it? Eur J Trauma Emerg Surg. 2020;46:245-64.
• Cebalo N, Bašić Kes V, Urlić I, et al. The effect of transcoutaneous electrical nerve stimulation on pain control during dental procedure in children 9-14 years old. Psychiatr Danub. 2021;33:1316-9.
• Vance CG, Dailey DL, Rakel BA, Sluka KA. Using TENS for pain control: the state of the evidence. Pain Manag. 2014;4:197-209.
• Zhou P, He F, Liu B, Wei S. Nerve electrical stimulation enhances osseointegration of implants in the beagle. Sci Rep. 2019;9:4916.
• Tomofuji T, Ekuni D, Azuma T, et al. Effects of electrical stimulation on periodontal tissue remodeling in rats. J Periodontal Res. 2013;48:177-83.
• Yonemori K, Matsunga S, Ishidou Y, et al. Early effect of electrical stimulation on osteogbenesis. Bone. 1996;19:173-80.
• Pettersen E, Anderson J, Ortiz-Catalan M. Electrical stimulation to promote osseointegration of bone anchoring implants: a topical review. J Neuroeng Rehabil. 2022;21;19:31.
• Bassett C, Pawluck RJ, Becker RO. Effects of electric current on bone in vivo. Nature. 1964;204:652-4.
• Matsumoto M, Ochi M, Abiko Y, et al. Pulsed elevtromagnetic fields promote bone formation around dental implants inserted into the femur of rabbits. Clin Oral Impl Res. 2000;11:354-60.
• Giannunzio GA, Speerli RC, Guglielmotti MB. Electrical field effect on peri-implant osteogenesis: a histologic and histomorphometric study. Implant Dent. 2008;17:118-26.
• Zhao Z, Watt C, Karystinou A, et al. Directed migration of human bone marrow mesenchymal stem cells in a physiological direct current electric field. Eur Cell Mater. 2011;29:344-58.
• Ciombor DM, Lester G, Aaron RK, et al. Low frequency EMF regulates chondrocyte differentiation and expression of matrix proteins. J Orthop Res. 2002;20:40-50.
• Schwart Z, Simon BJ, Duran MA, et al. Pulsed electromagnetic fields enhance BMP-2 dependent osteoblastic differantiation of human mesenchymal stem cells. J Orthop Res. 2008;9:1250-5.
• Sun LY, Hsieh DK, Lin PC, et al. Pulsed electromagnetic fields accelerate proliferation and osteogenic gene expression in human bone marrow mesenchymal stem cells during osteogenic differentiation. Bioelectromagnetics. 2010;31:209-19.
• Gittens RA, Navarrete RO, Rettew R, et al. Electrical polarization of titanium surfaces for the enhancement of osteoblast differantiation. Bioelectromagnetics. 2013;34:599-612.
• Diniz P, Shomura K, Soejima K, Ito G. Effect of pulsed electromagnetionec field (PEMF) stimulation on bone tissue like formation are dependent on the maturation stages of the osteoblasts. Bioelectromagnetics. 2002;23:398-405.
• Jansen JH, van der Jagt OP, Punt BJ, et al. Stimulation of osteogenic differentiation in human osteoprogenitor cells by pulsed electromagnetic fields: an in vitro study. BMC Musculoskelet Disord. 2010;23;11:188.
• Ochi M, Wang PL, Ohura K, et al. Solcoseryl, a tissue respiration stimulating agent, significantly enhances the effect of capacitively coupled electric field on the promotion of bone formation around dental implants. Clin Oral Impl Res. 2003;14:294-302.
• Song JK, Cho TH, Pan H, et al. An electronic device for accelerating bone formation in tissues surrounding a dental implant. Bioelectromagnetics. 2009;30:374-84.