Araştırma Makalesi
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Investigation of the prevalence of cystic echinococcosis in Gaziantep-Türkiye by ELI.H.A Echinococcus ELITech between 2015-2022

Yıl 2024, Cilt: 25 Sayı: 1, 91 - 96, 15.04.2024
https://doi.org/10.23902/trkjnat.1366489

Öz

In this study, 1811 serum samples of 1764 patients who applied to the parasitology laboratory of Gaziantep Dr. Ersin Arslan Training and Research Hospital between 1 January 2015 and 31 December 2022 with preliminary diagnosis of cystic echinococcosis (CE) were investigated, in order to evaluate the demographic data of the patients and CE seropositivity on an annual base. 1811 serum samples were analyzed by ELI.H.A Echinococcus ELITech (MICROBIO, France) test which is based on the indirect haemagglutination principle. Seropositivity was detected in a total of 519 patients. Of the patients who were found to be positive, 341 were women and 178 were men.
The highest positivity rate was found in patients over 50 years of age (29.3%), followed by the 20-30 age group (23.1%) and the 30-40 age group (22.9%), respectively.
While 232 of the admitted patients with preliminary diagnosis of CE were Syrians, 1532 patients were Turkish citizens. The positivity rate in Syrian patients was determined to be 41.8%, (n=100) while this rate was 26.7% (n=419) in Turkish patients. Despite the developments in the socioeconomic field, the investments of local governments in sanitation and the establishment of single health awareness, CE continues to exist as an important public health problem in Gaziantep due to both the effect of migration and the inability to reach the desired levels of personal hygiene.

Etik Beyan

Ethics committee approval for the study was received from Gaziantep University Clinical Research Ethics Committee Committee (Decision No: 2023/24).

Destekleyen Kurum

Gaziantep University Clinical Research Ethics Committee

Kaynakça

  • 1. Agudelo Higuita, N.I., Brunetti, E. & McCloskey, C. 2016. Cystic echinococcosis. Journal of Clinical Microbiology, 54: 518-523. https://doi.org/10.1128/jcm.02420-15
  • 2. Altıntaş, N., Topluoğlu, S., Yıldırım, A., Uslu, H., Ekşi, F., Ok, Ü.Z., Arslan, M.Ö., Kayaalp, C., Seçer, M., Kılıç, S., Karaman, Ü., Beyhan, Y.E., Öncel, T., Okumuş, B., Erol, U., Sertkaya, B., Gülyaz, V., Keskinkılıç, B., Kara, F., Doğanay, M. & Meşe, E.A. 2020. Türkiye’de Kistik Ekinokokkoz Mevcut Durum Raporu. Turkish Bulletin of Hygiene and Experimental Biology, 77(EK-3): 1-52. https://doi.org/10.51754/cusbed.880941
  • 3. Alver, O., Payaslıoğlu, A.M., Özakın, C. & Esen S. 2021. Laboratory Results of Cystic Echinococcosis in 2017 and 2018. Turkiye Parazitoloji Dergisi, 45(3): 207-210. https://doi.org/10.4274/tpd.galenos.2021.43434
  • 4. Arslan, M.Ö., Mor, N. & Bedir H. 2022. Seropozitifity of Anti-Echinococcus granulosus in Patients with of Clinical Prediagnosis Cystic Echinococcosis at Kafkas University Health Research and Application Hospital. Turkiye Parazitoloji Dergisi, 46(2): 129-32. https://doi.org/10.4274/tpd.galenos.2022.00719
  • 5. Başer, S., Ismayıl, A. & Maçin, S. 2021. Evaluation of the seropositivity of patients with cystic echinococcosis in Konya, Turkey. Journal of Contemporary Medicine, 11(2): 139-141. https://doi.org/10.16899/jcm.783172
  • 6. Beyhan, Y., Babür, C., Mungan, M. & Taylan Ozkan, A. 2015. Türkiye Halk Sağlığı Kurumu Ulusal Parazitoloji Referans Laboratuvarı'na 2009-2013 Yılları Arasında Başvuran Kistik Ekinokokkozis Şüpheli Hastaların Değerlendirilmesi. Türkiye Parazitoloji Dergisi, 39(1): 17-21. https://doi.org/10.5152/tpd.2015.3646
  • 7. Bhutani, N. & Kajal, P. 2018. Hepatic echinococcosis: A review. Annals of Medicine and Surgery, 36: 99-105. doi: 10.1016/j.amsu.2018.10.032 PMID: 30450204; PMCID: PMC6226561
  • 8. Çelik, T., Alev, C., Akgün, S., Güldoğan, E. & Şahin, F. 2022. A Retrospective Evaluation of Serological Results of Cystic Echinococcosis Suspected Cases Admitted to Adıyaman Training and Research Hospital Between 2013-2020. Turkiye Parazitoloji Dergisi, 46(2): 140-4. https://doi.org/10.4274/tpd.galenos.2021.29591
  • 9. European Centre for Disease Prevention and Control, 2022. Echinococcosis. In: ECDC. Annual epidemiological report for 2020. Stockholm: ECDC.
  • 10. Ending the neglect to attain the Sustainable Development Goals: a road map for neglected tropical diseases 2021-2030. Geneva: World Health Organization; 2020.
  • 11. Ertabaklar, H., Yıldız, İ., Malatyalı, E., Tileklioğlu, E., Çalışkan, S.Ö. & Ertuğ, S. 2019. Aydın Adnan Menderes Üniversitesi Eğitim ve Araştırma Hastanesi Parazitoloji Laboratuvarı’na 2005-2017 Yılları Arasında Kistik Ekinokokkozis Şüphesiyle Başvuran Olguların Retrospektif Olarak Değerlendirilmesi. Turkiye Parazitoloji Dergisi, 43(3): 118-22. https://doi.org/10.4274/tpd.galenos.2019.6218
  • 12. Eryıldız, C., Tarladaçalısır, T., Kuyucuklu, G., Çakmakçı, B. & Sakru, N. (2022). Serological Follow-up of Human Cystic Echinococcosis in the Thrace Region, Turkey. Iranian Journal of Parasitology, 17(4): 517-524 https://doi.org/10.18502/ijpa.v17i4.11279
  • 13. Göç İdaresi Başkanlığı 2024. Temporary Protection. https://en.goc.gov.tr/temporary-protection27 (Date accessed: 26.04.2020)
  • 14. Kara, M., Damarcı, İ. & Dabanlıoğlu, B. 2020. Prevalence of cystic echinococcosis in humans in Erzincan Province. Annals of Medical Research, 27(1): 128-132. 10.5455/annalsmedres.2019.11.685
  • 15. Mandal, S. & Mandal, M.D. 2012. Human cystic echinococcosis: Epidemiologic, zoonotic, clinical, diagnostic and therapeutic aspects. Asian Pacific Journal of Tropical Medicine, 5(4): 253-260. https://doi.org/10.1016/S1995-7645(12)60035-2
  • 16. Samancı Aktar, G., Ayaydın, Z., Rahmanalı Onur, A., Uzala Mızraklı, A. & Tekay, F. 2020, Retrospective Evaluation of Cases with the Pre-diagnosis of Cystic Echinococcosis Admitted to the Microbiology Laboratory of Diyarbakır Health Sciences Gazi Yaşargil Training and Research Hospital Between 2014 and 2017. Turkiye Parazitoloji Dergisi, 44(4): 207-10. https://doi.org/10.4274/tpd.galenos.2020.6592
  • 17. Siles-Lucas, M., Uchiumi, L. & Tamarozzi, F. 2023 Oct. 'No cyst, no echinococcosis': a scoping review update on the diagnosis of cystic echinococcosis after the issue of the WHO-IWGE Expert Consensus and current perspectives. Current Opinion in Infectious Diseases, 36(5): 333-340. https://doi.org/10.1097/QCO.0000000000000941.
  • 18. Tamarozzi, F., Akhan, O., Cretu, CM., Vutova, K., Akinci, D., Chipeva, R., Ciftci, T., Constantin, C. M., Fabiani, M., Golemanov, B., Janta, D., Mihailescu, P., Muhtarov, M., Örsten, S., Petrutescu, M., Pezzotti, P., Popa, A. C., Popa, L. G., Popa, M. I., Velevi V., Siles-Lucas, M., Brunett, E. & Casulli, A. 2018. Prevalence of abdominal cystic echinococcosis in rural Bulgaria, Romania, and Turkey: a cross-sectional, ultrasound-based, population study from the HERACLES project. Lancet Infectious Diseases, 18: 769-78. https://doi.org/10.1016/S1473-3099(18)30221-4
  • 19. Tamarozzi, F., Legnardi, M., Fittipaldo, A., Drigo, M. & Cassini, R. 2020 Epidemiological distribution of Echinococcus granulosus s.l. infection in human and domestic animal hosts in European Mediterranean and Balkan countries: A systematic review. PLoS Neglected Tropical Diseases, 14(8): e0008519. https://doi.org/10.1371/journal. pntd.0008519
  • 20. Ulusan Bağcı, Ö. 2023. Evaluation of the Impact of the COVID-19 Pandemic on Cystic Echinococcosis Indirect Hemagglutination Test Dynamics: A Single-center Experience. Turkiye Parazitoloji Dergisi, 47(3): 166-70. https://doi.org/10.4274/tpd.galenos.2023.42104
  • 21. CDC, 2023. About Echinococcosis. www.cdc.gov/parasites/echinococcosis/gen_info/index.html (Date accessed: 23.09.2020)
  • 22. WHO, 2023. www.who.int/news-room/fact-sheets/detail/echinococcosis (Date accessed: 17.05.2021)
  • 23. WHO, ‎2015‎. WHO estimates of the global burden of foodborne diseases: foodborne disease burden epidemiology reference group 2007-2015. World Health Organization. https://iris.who.int/handle/10665/199350 (Date accessed: 25.05.2022)
  • 24. Yılmaz, A., Uslu, H. & Aktaş, F. 2016. 2009-2013 Yılları Arasında Erzurum Bölge Hastanesindeki Kistik Ekinokokkozis Şüpheli Hastaların İndirekt Hemaglütinasyon (İHA) Metoduyla Değerlendirilmesi. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi, 5(1): 23-32
  • 25. Yürük, M., Yaman, O., Sivcan, E. & Erdoğan, E. 2022. Retrospective Determination of the Prevelense of AntiEchinococcus granulosus Antibodies in Cystic Echinococcosis Pre-diagnosed Patients at Erciyes University Faculty of Medicine. Turkiye Parazitoloji Dergisi, 46(2): 133-139 https://doi.org/10.4274/tpd.galenos.2022.32032
Yıl 2024, Cilt: 25 Sayı: 1, 91 - 96, 15.04.2024
https://doi.org/10.23902/trkjnat.1366489

Öz

Bu çalışmada 1 Ocak 2015 - 31 Aralık 2022 tarihleri arasında Gaziantep Dr. Ersin Aslan Eğitim ve Araştırma Hastanesi parazitoloji laboratuvarına kistik ekinokokkoz ön tanısıyla başvuran 1764 hastanın 1811 serum örnekleri araştırıldı. Hastaların demografik verilerinin yanı sıra kistik ekinokokkoz seropozitifliğinin yıllara göre değerlendirilmesi amaçlandı. 1811 serum örneği indirekt hemaglütinasyon prensibine dayanan ELI.H.A Echinococcus ELITech (MICROBIO, Fransa) testi ile retrospektif olarak analiz edildi. Toplam 519 hastada seropozitiflik tespit edildi. Pozitif olduğu tespit edilen hastaların 341'i kadın, 178'i erkekti.
En yüksek pozitiflik oranı 50 yaş üstü hastalarda (%29,3) görüldü, bunu sırasıyla 20-30 yaş grubu (%23,1) ve 30-40 yaş grubu (%22,9) izledi.
KE ön tanısı ile başvuru yapan hastaların 232'si Suriyeli, 1532'si ise Türk vatandaşıydı. Suriyeli hastalarda pozitiflik oranı %41,8 (n=100), Türk hastalarda ise bu oran %26,7 (n=419) olarak belirlendi. Sosyoekonomik alanda yaşanan gelişmelere, yerel yönetimlerin sanitasyona yönelik yatırımlarına ve tek sağlık bilincinin yerleşmesine rağmen, gerek göçün etkisi gerekse kişisel hijyen düzeyinde istenilen seviyelere ulaşılamaması nedeniyle Gaziantep’te kistik ekinokokkozis önemli bir halk sağlığı sorunu olarak varlığını sürdürmektedir.

Kaynakça

  • 1. Agudelo Higuita, N.I., Brunetti, E. & McCloskey, C. 2016. Cystic echinococcosis. Journal of Clinical Microbiology, 54: 518-523. https://doi.org/10.1128/jcm.02420-15
  • 2. Altıntaş, N., Topluoğlu, S., Yıldırım, A., Uslu, H., Ekşi, F., Ok, Ü.Z., Arslan, M.Ö., Kayaalp, C., Seçer, M., Kılıç, S., Karaman, Ü., Beyhan, Y.E., Öncel, T., Okumuş, B., Erol, U., Sertkaya, B., Gülyaz, V., Keskinkılıç, B., Kara, F., Doğanay, M. & Meşe, E.A. 2020. Türkiye’de Kistik Ekinokokkoz Mevcut Durum Raporu. Turkish Bulletin of Hygiene and Experimental Biology, 77(EK-3): 1-52. https://doi.org/10.51754/cusbed.880941
  • 3. Alver, O., Payaslıoğlu, A.M., Özakın, C. & Esen S. 2021. Laboratory Results of Cystic Echinococcosis in 2017 and 2018. Turkiye Parazitoloji Dergisi, 45(3): 207-210. https://doi.org/10.4274/tpd.galenos.2021.43434
  • 4. Arslan, M.Ö., Mor, N. & Bedir H. 2022. Seropozitifity of Anti-Echinococcus granulosus in Patients with of Clinical Prediagnosis Cystic Echinococcosis at Kafkas University Health Research and Application Hospital. Turkiye Parazitoloji Dergisi, 46(2): 129-32. https://doi.org/10.4274/tpd.galenos.2022.00719
  • 5. Başer, S., Ismayıl, A. & Maçin, S. 2021. Evaluation of the seropositivity of patients with cystic echinococcosis in Konya, Turkey. Journal of Contemporary Medicine, 11(2): 139-141. https://doi.org/10.16899/jcm.783172
  • 6. Beyhan, Y., Babür, C., Mungan, M. & Taylan Ozkan, A. 2015. Türkiye Halk Sağlığı Kurumu Ulusal Parazitoloji Referans Laboratuvarı'na 2009-2013 Yılları Arasında Başvuran Kistik Ekinokokkozis Şüpheli Hastaların Değerlendirilmesi. Türkiye Parazitoloji Dergisi, 39(1): 17-21. https://doi.org/10.5152/tpd.2015.3646
  • 7. Bhutani, N. & Kajal, P. 2018. Hepatic echinococcosis: A review. Annals of Medicine and Surgery, 36: 99-105. doi: 10.1016/j.amsu.2018.10.032 PMID: 30450204; PMCID: PMC6226561
  • 8. Çelik, T., Alev, C., Akgün, S., Güldoğan, E. & Şahin, F. 2022. A Retrospective Evaluation of Serological Results of Cystic Echinococcosis Suspected Cases Admitted to Adıyaman Training and Research Hospital Between 2013-2020. Turkiye Parazitoloji Dergisi, 46(2): 140-4. https://doi.org/10.4274/tpd.galenos.2021.29591
  • 9. European Centre for Disease Prevention and Control, 2022. Echinococcosis. In: ECDC. Annual epidemiological report for 2020. Stockholm: ECDC.
  • 10. Ending the neglect to attain the Sustainable Development Goals: a road map for neglected tropical diseases 2021-2030. Geneva: World Health Organization; 2020.
  • 11. Ertabaklar, H., Yıldız, İ., Malatyalı, E., Tileklioğlu, E., Çalışkan, S.Ö. & Ertuğ, S. 2019. Aydın Adnan Menderes Üniversitesi Eğitim ve Araştırma Hastanesi Parazitoloji Laboratuvarı’na 2005-2017 Yılları Arasında Kistik Ekinokokkozis Şüphesiyle Başvuran Olguların Retrospektif Olarak Değerlendirilmesi. Turkiye Parazitoloji Dergisi, 43(3): 118-22. https://doi.org/10.4274/tpd.galenos.2019.6218
  • 12. Eryıldız, C., Tarladaçalısır, T., Kuyucuklu, G., Çakmakçı, B. & Sakru, N. (2022). Serological Follow-up of Human Cystic Echinococcosis in the Thrace Region, Turkey. Iranian Journal of Parasitology, 17(4): 517-524 https://doi.org/10.18502/ijpa.v17i4.11279
  • 13. Göç İdaresi Başkanlığı 2024. Temporary Protection. https://en.goc.gov.tr/temporary-protection27 (Date accessed: 26.04.2020)
  • 14. Kara, M., Damarcı, İ. & Dabanlıoğlu, B. 2020. Prevalence of cystic echinococcosis in humans in Erzincan Province. Annals of Medical Research, 27(1): 128-132. 10.5455/annalsmedres.2019.11.685
  • 15. Mandal, S. & Mandal, M.D. 2012. Human cystic echinococcosis: Epidemiologic, zoonotic, clinical, diagnostic and therapeutic aspects. Asian Pacific Journal of Tropical Medicine, 5(4): 253-260. https://doi.org/10.1016/S1995-7645(12)60035-2
  • 16. Samancı Aktar, G., Ayaydın, Z., Rahmanalı Onur, A., Uzala Mızraklı, A. & Tekay, F. 2020, Retrospective Evaluation of Cases with the Pre-diagnosis of Cystic Echinococcosis Admitted to the Microbiology Laboratory of Diyarbakır Health Sciences Gazi Yaşargil Training and Research Hospital Between 2014 and 2017. Turkiye Parazitoloji Dergisi, 44(4): 207-10. https://doi.org/10.4274/tpd.galenos.2020.6592
  • 17. Siles-Lucas, M., Uchiumi, L. & Tamarozzi, F. 2023 Oct. 'No cyst, no echinococcosis': a scoping review update on the diagnosis of cystic echinococcosis after the issue of the WHO-IWGE Expert Consensus and current perspectives. Current Opinion in Infectious Diseases, 36(5): 333-340. https://doi.org/10.1097/QCO.0000000000000941.
  • 18. Tamarozzi, F., Akhan, O., Cretu, CM., Vutova, K., Akinci, D., Chipeva, R., Ciftci, T., Constantin, C. M., Fabiani, M., Golemanov, B., Janta, D., Mihailescu, P., Muhtarov, M., Örsten, S., Petrutescu, M., Pezzotti, P., Popa, A. C., Popa, L. G., Popa, M. I., Velevi V., Siles-Lucas, M., Brunett, E. & Casulli, A. 2018. Prevalence of abdominal cystic echinococcosis in rural Bulgaria, Romania, and Turkey: a cross-sectional, ultrasound-based, population study from the HERACLES project. Lancet Infectious Diseases, 18: 769-78. https://doi.org/10.1016/S1473-3099(18)30221-4
  • 19. Tamarozzi, F., Legnardi, M., Fittipaldo, A., Drigo, M. & Cassini, R. 2020 Epidemiological distribution of Echinococcus granulosus s.l. infection in human and domestic animal hosts in European Mediterranean and Balkan countries: A systematic review. PLoS Neglected Tropical Diseases, 14(8): e0008519. https://doi.org/10.1371/journal. pntd.0008519
  • 20. Ulusan Bağcı, Ö. 2023. Evaluation of the Impact of the COVID-19 Pandemic on Cystic Echinococcosis Indirect Hemagglutination Test Dynamics: A Single-center Experience. Turkiye Parazitoloji Dergisi, 47(3): 166-70. https://doi.org/10.4274/tpd.galenos.2023.42104
  • 21. CDC, 2023. About Echinococcosis. www.cdc.gov/parasites/echinococcosis/gen_info/index.html (Date accessed: 23.09.2020)
  • 22. WHO, 2023. www.who.int/news-room/fact-sheets/detail/echinococcosis (Date accessed: 17.05.2021)
  • 23. WHO, ‎2015‎. WHO estimates of the global burden of foodborne diseases: foodborne disease burden epidemiology reference group 2007-2015. World Health Organization. https://iris.who.int/handle/10665/199350 (Date accessed: 25.05.2022)
  • 24. Yılmaz, A., Uslu, H. & Aktaş, F. 2016. 2009-2013 Yılları Arasında Erzurum Bölge Hastanesindeki Kistik Ekinokokkozis Şüpheli Hastaların İndirekt Hemaglütinasyon (İHA) Metoduyla Değerlendirilmesi. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi, 5(1): 23-32
  • 25. Yürük, M., Yaman, O., Sivcan, E. & Erdoğan, E. 2022. Retrospective Determination of the Prevelense of AntiEchinococcus granulosus Antibodies in Cystic Echinococcosis Pre-diagnosed Patients at Erciyes University Faculty of Medicine. Turkiye Parazitoloji Dergisi, 46(2): 133-139 https://doi.org/10.4274/tpd.galenos.2022.32032
Toplam 25 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Parazitoloji
Bölüm Araştırma Makalesi/Research Article
Yazarlar

Ahmet Özkeklikçi 0000-0003-1619-4156

Osman Sezer Cirit 0000-0003-1064-3766

Erken Görünüm Tarihi 5 Nisan 2024
Yayımlanma Tarihi 15 Nisan 2024
Gönderilme Tarihi 26 Eylül 2023
Kabul Tarihi 21 Şubat 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 25 Sayı: 1

Kaynak Göster

APA Özkeklikçi, A., & Cirit, O. S. (2024). Investigation of the prevalence of cystic echinococcosis in Gaziantep-Türkiye by ELI.H.A Echinococcus ELITech between 2015-2022. Trakya University Journal of Natural Sciences, 25(1), 91-96. https://doi.org/10.23902/trkjnat.1366489
AMA Özkeklikçi A, Cirit OS. Investigation of the prevalence of cystic echinococcosis in Gaziantep-Türkiye by ELI.H.A Echinococcus ELITech between 2015-2022. Trakya Univ J Nat Sci. Nisan 2024;25(1):91-96. doi:10.23902/trkjnat.1366489
Chicago Özkeklikçi, Ahmet, ve Osman Sezer Cirit. “Investigation of the Prevalence of Cystic Echinococcosis in Gaziantep-Türkiye by ELI.H.A Echinococcus ELITech Between 2015-2022”. Trakya University Journal of Natural Sciences 25, sy. 1 (Nisan 2024): 91-96. https://doi.org/10.23902/trkjnat.1366489.
EndNote Özkeklikçi A, Cirit OS (01 Nisan 2024) Investigation of the prevalence of cystic echinococcosis in Gaziantep-Türkiye by ELI.H.A Echinococcus ELITech between 2015-2022. Trakya University Journal of Natural Sciences 25 1 91–96.
IEEE A. Özkeklikçi ve O. S. Cirit, “Investigation of the prevalence of cystic echinococcosis in Gaziantep-Türkiye by ELI.H.A Echinococcus ELITech between 2015-2022”, Trakya Univ J Nat Sci, c. 25, sy. 1, ss. 91–96, 2024, doi: 10.23902/trkjnat.1366489.
ISNAD Özkeklikçi, Ahmet - Cirit, Osman Sezer. “Investigation of the Prevalence of Cystic Echinococcosis in Gaziantep-Türkiye by ELI.H.A Echinococcus ELITech Between 2015-2022”. Trakya University Journal of Natural Sciences 25/1 (Nisan 2024), 91-96. https://doi.org/10.23902/trkjnat.1366489.
JAMA Özkeklikçi A, Cirit OS. Investigation of the prevalence of cystic echinococcosis in Gaziantep-Türkiye by ELI.H.A Echinococcus ELITech between 2015-2022. Trakya Univ J Nat Sci. 2024;25:91–96.
MLA Özkeklikçi, Ahmet ve Osman Sezer Cirit. “Investigation of the Prevalence of Cystic Echinococcosis in Gaziantep-Türkiye by ELI.H.A Echinococcus ELITech Between 2015-2022”. Trakya University Journal of Natural Sciences, c. 25, sy. 1, 2024, ss. 91-96, doi:10.23902/trkjnat.1366489.
Vancouver Özkeklikçi A, Cirit OS. Investigation of the prevalence of cystic echinococcosis in Gaziantep-Türkiye by ELI.H.A Echinococcus ELITech between 2015-2022. Trakya Univ J Nat Sci. 2024;25(1):91-6.

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