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Optogenetik

Yıl 2018, Cilt: 23 Sayı: 2, 182 - 191, 31.08.2018

Öz

Optogenetik,
genetik olarak ışığa duyarlı araçlar kullanılarak canlı doku ve hücrelerde
belirlenmiş hücresel aktiviteleri izlemek için optik ve moleküler stratejilerin
bütünüdür. Optogenetik; parkinson, epilepsi ve görme kaybı da dâhil olmak üzere
çeşitli nörolojik bozuklukların altında yatan mekanizmalar ve optogenetik
terapiler için düzeltici stratejilerin gelişimine katkı sağlamaktadır. Özellikle
optogentik çalışmalar, yakın gelecekte insanlarda gerçek görsel yenilenmeye
dönüştürülebilir ve rejeneratif tıp alanında yeni sınırlara ulaşabilir.

Kaynakça

  • Kaynaklar
  • Agus, V. and Janovjak, H., 2017. Optogenetic methods in drug screening: Technologies and applications, Current Opinion in Biotechnology, 48, 8–14.Alp, M.İ., 2014. Optogenetiğin temelleri, European Journal of Basic Medical Science, 4 (2), 37-4.Alp, M.İ., 2017. Açlık kuramına yeni bir bakış: Arkuat çekirdeğin optogenetik olarak uyarılmasının kognitif davranış üzerine etkisi, Doktora Tezi, Selçuk Üniversitesi, Sağlık Bilimleri Enstitüsü, Konya.Aston-Jones, G. and Deisseroth, K., 2013. Recent advances in optogenetics and pharmacogenetics, Brain Research, 1511, 1–5.Boyden, E.S., 2011. A history of optogenetics: the development of tools for controlling brain circuits with light, F1000 Biology Reports, 3 (11), 1-12.Crocini, C., Ferrantini, C., Pavone, F.S. and Sacconi, L., 2017. Optogenetics gets to the heart: a guiding light beyond defibrillation, Progress in Biophysics and Molecular Biology, 130, 132-139.Cunningham, M., Cho, J.H., Leung, A., Savvidis, G., Ahn, S., Moon, M., Lee, P.K.J., Han, J.J., Azimi, N., Kim, K.S., Bolshakov, V.Y. and Chung, S., 2014. Hpsc-derived maturing gabaergic interneurons ameliorate seizures and abnormal behavior in epileptic mice, Cell Stem Cell, 15 (5), 559–73.Deisseroth, K., 2012. Optogenetics and psychiatry: applications, challenges, and opportunities, Biological Psychiatry, 71, 1030–1032.Fine, I., Cepko, C.L. and Landy, M.S., 2015. Vision research special issue: sight restoration: Prosthetics, optogenetics and gene therapy, Vision Research, 111, 115–123.G, N., Tan, A., Farhatnia, Y., Rajadas, J., Hamblin, M.R., Khaw, P.T. and Seifalian, A.M., 2013. Channelrhodopsins: Visual regeneration and neural activation by a light switch, New Biotechnology, 30 (5), 1-14.Goshen, I., 2014. The optogenetic revolution in memory research, Trends in Neurosciences, 37 (9), 511-522.Gradinaru, V., Thompson, K.R., Zhang, F., Mogri, M., Kay, K., Schneider, M.B. and Deisseroth, K., 2007. Targeting and readout strategies for fast optical neural control ın vitro and ın vivo, The Journal of Neuroscience, 27 (52), 14231–14238.Kambli, L., Bhatt, L.K., Oza, M. and Prabhavalkar, K., 2017. Novel therapeutic targets for epilepsy intervention, Seizure, 51, 27–34.Kasparov, S., 2012. Optogenetics, Primer on the Autonomic Nervous System, 3, 689–691.Kielbus, M., Czapinski, J., Odrzywolksi, A., Stasiak, K., Kalafut, J., Kos, M., Giannopoulos, K., Stepulak, A., and Rivero-Müller, A., 2018. Optogenetics in cancer drug discovery, Expert Opin Drug Discov, 13 (5), 459-472.Liu, Q. and Tucker, Q.C., 2017. engineering genetically-encoded tools for optogenetic control of protein activity, Current Opinion in Chemical Biology, 40, 17–23.Lőrincz, M.L. and Adamantidis, A.R., 2017. Monoaminergic control of brain states and sensory processing: existing knowledge and recent insights obtained with optogenetics, Progress in Neurobiology, 151, 237–253.Luchkina, N.V. and Bolshakov, V.Y., 2017. Diminishing Fear: Optogenetic approach toward understanding neural circuits of fear control, Pharmacology, Biochemistry and Behavior, xxx (xxxx), xxx–xxx.Mahmoudi, P., Veladi, H. and Pakdel, P.G., 2017. Optogenetics, tools and applications in neurobiology, Journal of Medical Signals in Sensors, 7 (2), 71-79.Marton, T.F and Sohal, V.S., 2016. Of mice, men, and microbial opsins: how optogenetics can help hone mouse models of mental ıllness, Society of Biological Psychiatry, 79, 47-52.Ordaz, J.D., Wu, W. and Xu, X.M., 2017. Optogenetics and its application in neural degeneration and regeneration, Neural Regeneration Research, 12 (8), 1197-1209.Özçelik, G., 2016. A thesis submitted fort he degree of master of science department of molecular biology and genetics, Doktora Tezi, Gebze Teknik Üniversitesi, Fen Bilimleri Enstitüsü, Gebze.Parker, K.L., Kim, Y., Alberico, S.L., Emmons, E.B. and Narayanan, N.S., 2016. Optogenetic approaches to evaluate striatal function in animal models of parkinson disease, Dialogues in Clinical Neuroscience, 18 (1), 99-107.Peled, A., 2011. Optogenetic neuronal control in schizophrenia, Medical Hypotheses, 76, 914–921.Pianca, N., Zaglia, T. and Mongillo, M., 2017. Will cardiac optogenetics find the way through the obscure angles of heart physiology?, Biochemical and Biophysical Research Communications, 482, 515-523.Smith, K.S. and Graybiel, A.M., 2013. Using optogenetics to study habits, Braın Research, 1511, 102-114.Tønnesen, J., 2013. Optogenetic cell control in experimental models of neurological disorders, Behavioural Brain Research, 255, 35– 43.Touriño, C., Eban-Rothschild, A. and Lecea, L., 2013. Optogenetics in psychiatric diseases, Current Opinion in Neurobiology, 23, 430–435.Towne, C., Montgomery, K.L., Iyer , S.M., Deisseroth, K. and Delp, S.L., 2013. Optogenetic control of targeted peripheral axons in freely moving animals, Plos One, 8 (8), 1-10.Uedo, Y. and Sato, M., 2017. Cell membrane dynamics induction using optogenetic tools, Biochemical and Biophysical Research Communication, xxx, 1-7.Vazey, E.M. and Aston-Jones, G., 2013. New tricks for old dogmas: optogenetic and designer receptor insights for parkinson’s disease, Brain Research, 1511, 153-163.Wykes, R.C., Kullmann, D.M., Pavlov, I. and Magloire, V., 2016. Optogenetic approaches to treat epilepsy, Journal of Neuroscience Methods, 260, 215–220.Yan, B., Vakulenko, M., Min, S.H., Hauswirth,W.W and Nirenberg, S., 2016. Maintaining ocular safety with light exposure, focusing on devices for optogenetic stimulation, Vision Research, 121, 57–71.Yang, Q., Song, D. and Qing, H., 2017. Neural changes in alzheimer’s disease from circuit to molecule: perspective of optogenetics, Neuroscience and Biobehavioral Reviews, 79, 110–118.Young, A. and Wimmer, R.D., 2017. Implications for the thalamic reticular nucleus in impaired attention and sleep in schizophrenia, Schizophrenia Research, 180, 44–47.Zhang, H. and Cohen, A.E., 2017. Optogenetic approaches to drug discovery in neuroscience and beyond, Trends in Biotechnology, 35 (7), 625-639.Zhao, M., Alleva, R., Ma, H., Daniel, A.G.S. and Schwartz, T.H., 2015. Optogenetic tools for modulating and probing the epileptic network, Epilepsy Research, 116, 15–26.
Yıl 2018, Cilt: 23 Sayı: 2, 182 - 191, 31.08.2018

Öz

Kaynakça

  • Kaynaklar
  • Agus, V. and Janovjak, H., 2017. Optogenetic methods in drug screening: Technologies and applications, Current Opinion in Biotechnology, 48, 8–14.Alp, M.İ., 2014. Optogenetiğin temelleri, European Journal of Basic Medical Science, 4 (2), 37-4.Alp, M.İ., 2017. Açlık kuramına yeni bir bakış: Arkuat çekirdeğin optogenetik olarak uyarılmasının kognitif davranış üzerine etkisi, Doktora Tezi, Selçuk Üniversitesi, Sağlık Bilimleri Enstitüsü, Konya.Aston-Jones, G. and Deisseroth, K., 2013. Recent advances in optogenetics and pharmacogenetics, Brain Research, 1511, 1–5.Boyden, E.S., 2011. A history of optogenetics: the development of tools for controlling brain circuits with light, F1000 Biology Reports, 3 (11), 1-12.Crocini, C., Ferrantini, C., Pavone, F.S. and Sacconi, L., 2017. Optogenetics gets to the heart: a guiding light beyond defibrillation, Progress in Biophysics and Molecular Biology, 130, 132-139.Cunningham, M., Cho, J.H., Leung, A., Savvidis, G., Ahn, S., Moon, M., Lee, P.K.J., Han, J.J., Azimi, N., Kim, K.S., Bolshakov, V.Y. and Chung, S., 2014. Hpsc-derived maturing gabaergic interneurons ameliorate seizures and abnormal behavior in epileptic mice, Cell Stem Cell, 15 (5), 559–73.Deisseroth, K., 2012. Optogenetics and psychiatry: applications, challenges, and opportunities, Biological Psychiatry, 71, 1030–1032.Fine, I., Cepko, C.L. and Landy, M.S., 2015. Vision research special issue: sight restoration: Prosthetics, optogenetics and gene therapy, Vision Research, 111, 115–123.G, N., Tan, A., Farhatnia, Y., Rajadas, J., Hamblin, M.R., Khaw, P.T. and Seifalian, A.M., 2013. Channelrhodopsins: Visual regeneration and neural activation by a light switch, New Biotechnology, 30 (5), 1-14.Goshen, I., 2014. The optogenetic revolution in memory research, Trends in Neurosciences, 37 (9), 511-522.Gradinaru, V., Thompson, K.R., Zhang, F., Mogri, M., Kay, K., Schneider, M.B. and Deisseroth, K., 2007. Targeting and readout strategies for fast optical neural control ın vitro and ın vivo, The Journal of Neuroscience, 27 (52), 14231–14238.Kambli, L., Bhatt, L.K., Oza, M. and Prabhavalkar, K., 2017. Novel therapeutic targets for epilepsy intervention, Seizure, 51, 27–34.Kasparov, S., 2012. Optogenetics, Primer on the Autonomic Nervous System, 3, 689–691.Kielbus, M., Czapinski, J., Odrzywolksi, A., Stasiak, K., Kalafut, J., Kos, M., Giannopoulos, K., Stepulak, A., and Rivero-Müller, A., 2018. Optogenetics in cancer drug discovery, Expert Opin Drug Discov, 13 (5), 459-472.Liu, Q. and Tucker, Q.C., 2017. engineering genetically-encoded tools for optogenetic control of protein activity, Current Opinion in Chemical Biology, 40, 17–23.Lőrincz, M.L. and Adamantidis, A.R., 2017. Monoaminergic control of brain states and sensory processing: existing knowledge and recent insights obtained with optogenetics, Progress in Neurobiology, 151, 237–253.Luchkina, N.V. and Bolshakov, V.Y., 2017. Diminishing Fear: Optogenetic approach toward understanding neural circuits of fear control, Pharmacology, Biochemistry and Behavior, xxx (xxxx), xxx–xxx.Mahmoudi, P., Veladi, H. and Pakdel, P.G., 2017. Optogenetics, tools and applications in neurobiology, Journal of Medical Signals in Sensors, 7 (2), 71-79.Marton, T.F and Sohal, V.S., 2016. Of mice, men, and microbial opsins: how optogenetics can help hone mouse models of mental ıllness, Society of Biological Psychiatry, 79, 47-52.Ordaz, J.D., Wu, W. and Xu, X.M., 2017. Optogenetics and its application in neural degeneration and regeneration, Neural Regeneration Research, 12 (8), 1197-1209.Özçelik, G., 2016. A thesis submitted fort he degree of master of science department of molecular biology and genetics, Doktora Tezi, Gebze Teknik Üniversitesi, Fen Bilimleri Enstitüsü, Gebze.Parker, K.L., Kim, Y., Alberico, S.L., Emmons, E.B. and Narayanan, N.S., 2016. Optogenetic approaches to evaluate striatal function in animal models of parkinson disease, Dialogues in Clinical Neuroscience, 18 (1), 99-107.Peled, A., 2011. Optogenetic neuronal control in schizophrenia, Medical Hypotheses, 76, 914–921.Pianca, N., Zaglia, T. and Mongillo, M., 2017. Will cardiac optogenetics find the way through the obscure angles of heart physiology?, Biochemical and Biophysical Research Communications, 482, 515-523.Smith, K.S. and Graybiel, A.M., 2013. Using optogenetics to study habits, Braın Research, 1511, 102-114.Tønnesen, J., 2013. Optogenetic cell control in experimental models of neurological disorders, Behavioural Brain Research, 255, 35– 43.Touriño, C., Eban-Rothschild, A. and Lecea, L., 2013. Optogenetics in psychiatric diseases, Current Opinion in Neurobiology, 23, 430–435.Towne, C., Montgomery, K.L., Iyer , S.M., Deisseroth, K. and Delp, S.L., 2013. Optogenetic control of targeted peripheral axons in freely moving animals, Plos One, 8 (8), 1-10.Uedo, Y. and Sato, M., 2017. Cell membrane dynamics induction using optogenetic tools, Biochemical and Biophysical Research Communication, xxx, 1-7.Vazey, E.M. and Aston-Jones, G., 2013. New tricks for old dogmas: optogenetic and designer receptor insights for parkinson’s disease, Brain Research, 1511, 153-163.Wykes, R.C., Kullmann, D.M., Pavlov, I. and Magloire, V., 2016. Optogenetic approaches to treat epilepsy, Journal of Neuroscience Methods, 260, 215–220.Yan, B., Vakulenko, M., Min, S.H., Hauswirth,W.W and Nirenberg, S., 2016. Maintaining ocular safety with light exposure, focusing on devices for optogenetic stimulation, Vision Research, 121, 57–71.Yang, Q., Song, D. and Qing, H., 2017. Neural changes in alzheimer’s disease from circuit to molecule: perspective of optogenetics, Neuroscience and Biobehavioral Reviews, 79, 110–118.Young, A. and Wimmer, R.D., 2017. Implications for the thalamic reticular nucleus in impaired attention and sleep in schizophrenia, Schizophrenia Research, 180, 44–47.Zhang, H. and Cohen, A.E., 2017. Optogenetic approaches to drug discovery in neuroscience and beyond, Trends in Biotechnology, 35 (7), 625-639.Zhao, M., Alleva, R., Ma, H., Daniel, A.G.S. and Schwartz, T.H., 2015. Optogenetic tools for modulating and probing the epileptic network, Epilepsy Research, 116, 15–26.
Toplam 2 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Seda Beyaz

Abdullah Aslan

Yayımlanma Tarihi 31 Ağustos 2018
Gönderilme Tarihi 11 Haziran 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 23 Sayı: 2

Kaynak Göster

APA Beyaz, S., & Aslan, A. (2018). Optogenetik. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 23(2), 182-191.