Year 2019, Volume 5, Issue 1, Pages 1168 - 1176 2019-04-15

The relationship between monocyte to HDL cholesterol ratio, carotid intima-media thickness and type 2 diabetes mellitus
Tip 2 diyabet ile monosit-yüksek dansiteli lipoprotein kolesterol oranı ve karotis intima-media kalınlığı arasındaki ilişki

Hakan Kaya [1]

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Aim: Diyabetes mellitus (DM) is a majör risk factor for atheroscleros. Circulating monocyte count plays an important role for new atherosclerotic plaque development. Also, there is a strong inverse relationship between high density lipoprotein cholesterol (HDL) and atherosclerosis. monocyte count/HDL ratio (MHR) is a novel inflammatory marker for  atheroscleros. Carotid intima-media thickness (CIMT)   can predict  the presence or absence of  coronary artery disease (CAD). I aimed to investigate relationship between  CIMT, MHR and type 2 DM

 Methods: A total of 120 patients were divided into two groups (with type2 DM group = 60, control group: 60). Baseline characteristics, laboratory parameters, MHR and  CIMT were recorded and compared between groups.

Results: The Diabetes group had considerable  higher  CIMT, MHR  levels compared to the control (p<0.001,p<0,001 respectively ). Also, CIMT  levels showed significant correlation with blood glucose level (r=0.474, p<0.001). On the contrary, HDL levels were higher in the control group (p=0.010).

Conclusion: In conclusion, I found significantly higher  MHR and CIMT in the diabetic group and thus I think MHR, which is an easily calculated index, can be used in the daily clinical practice as an indicator of atherosclerosis in Type 2 DM patients.

Amaç: Diyabet ateroskleroz için  majör bir risk faktörüdür.  Dolaşımdaki monosit miktarı yeni aterosklerotik plak gelişiminde önemli bir rol oynar.  Ayrıca yüksek dansitelilipoprotein (HDL) kolesterol ve ateroskleroz  arasında güçlü bir ters  ilişki olduğu gösterilmiştir. Monosit ile HDL kolesterol oranı ateroskleroz için yeni bir inflamasyon belirtecidir. Karotisintimamedia kalınlığı (KİMK) koroner arter hastalığının olduğunu veya olmadığını gösterebilir.

Gereç ve yöntemler:  60 diyabet hastası ve 60 kontrol grubu olarak toplam 120 hasta iki gruba ayrıldı. Karakteristik özellikler, labaratuvar parametreleri, KİMK ve monosit ile HDL kolesterol oranları kaydedildi ve iki grup arasında karşılaştırıldı.

Bulgular: Diyabetik grupta KİMK ve monosit ile HDL oranı anlamlı derecede yüksek izlendi (p<0.001,p<0,001 sırasıyla). Ayrıca KİMK kan glukoz düzeyleri ile anlamlı derecede korelasyon gösterdi (r=0.474, p<0.001). Buna karşın, HDL oranı kontrol grubunda daha yüksekti (p=0,010).

Sonuç: Sonuç olarak, çalışmamda diyabetik grupta anlamlı olarak daha yüksek MHR ve CIMT düzeyleri tespit ettim ve böylece kolayca hesaplanan bir indeks olan MHR'nin, Tip 2 DM hastalarında aterosklerozun bir göstergesi olarak günlük klinik uygulamada kullanılabileceğini düşünüyorum.

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Primary Language en
Subjects Health Care Sciences and Services
Journal Section Araştırma/Research
Authors

Orcid: 0000-0002-5925-5150
Author: Hakan Kaya
Institution: ADIYAMAN ÜNİVERSİTESİ, TIP FAKÜLTESİ
Country: Turkey


Dates

Publication Date: April 15, 2019

Bibtex @research article { adiyamansaglik486890, journal = {Adıyaman Üniversitesi Sağlık Bilimleri Dergisi}, issn = {}, eissn = {2458-9179}, address = {Adıyaman University}, year = {2019}, volume = {5}, pages = {1168 - 1176}, doi = {10.30569/adiyamansaglik.486890}, title = {The relationship between monocyte to HDL cholesterol ratio, carotid intima-media thickness and type 2 diabetes mellitus}, key = {cite}, author = {Kaya, Hakan} }
APA Kaya, H . (2019). The relationship between monocyte to HDL cholesterol ratio, carotid intima-media thickness and type 2 diabetes mellitus. Adıyaman Üniversitesi Sağlık Bilimleri Dergisi, 5 (1), 1168-1176. DOI: 10.30569/adiyamansaglik.486890
MLA Kaya, H . "The relationship between monocyte to HDL cholesterol ratio, carotid intima-media thickness and type 2 diabetes mellitus". Adıyaman Üniversitesi Sağlık Bilimleri Dergisi 5 (2019): 1168-1176 <http://dergipark.org.tr/adiyamansaglik/issue/43834/486890>
Chicago Kaya, H . "The relationship between monocyte to HDL cholesterol ratio, carotid intima-media thickness and type 2 diabetes mellitus". Adıyaman Üniversitesi Sağlık Bilimleri Dergisi 5 (2019): 1168-1176
RIS TY - JOUR T1 - The relationship between monocyte to HDL cholesterol ratio, carotid intima-media thickness and type 2 diabetes mellitus AU - Hakan Kaya Y1 - 2019 PY - 2019 N1 - doi: 10.30569/adiyamansaglik.486890 DO - 10.30569/adiyamansaglik.486890 T2 - Adıyaman Üniversitesi Sağlık Bilimleri Dergisi JF - Journal JO - JOR SP - 1168 EP - 1176 VL - 5 IS - 1 SN - -2458-9179 M3 - doi: 10.30569/adiyamansaglik.486890 UR - https://doi.org/10.30569/adiyamansaglik.486890 Y2 - 2018 ER -
EndNote %0 Health Sciences Journal of Adıyaman University The relationship between monocyte to HDL cholesterol ratio, carotid intima-media thickness and type 2 diabetes mellitus %A Hakan Kaya %T The relationship between monocyte to HDL cholesterol ratio, carotid intima-media thickness and type 2 diabetes mellitus %D 2019 %J Adıyaman Üniversitesi Sağlık Bilimleri Dergisi %P -2458-9179 %V 5 %N 1 %R doi: 10.30569/adiyamansaglik.486890 %U 10.30569/adiyamansaglik.486890
ISNAD Kaya, Hakan . "The relationship between monocyte to HDL cholesterol ratio, carotid intima-media thickness and type 2 diabetes mellitus". Adıyaman Üniversitesi Sağlık Bilimleri Dergisi 5 / 1 (April 2019): 1168-1176. https://doi.org/10.30569/adiyamansaglik.486890
AMA Kaya H . The relationship between monocyte to HDL cholesterol ratio, carotid intima-media thickness and type 2 diabetes mellitus. Adıyaman Üniversitesi Sağlık Bilimleri Dergisi. 2019; 5(1): 1168-1176.
Vancouver Kaya H . The relationship between monocyte to HDL cholesterol ratio, carotid intima-media thickness and type 2 diabetes mellitus. Adıyaman Üniversitesi Sağlık Bilimleri Dergisi. 2019; 5(1): 1176-1168.