Year 2018, Volume 12, Issue 3, Pages 118 - 123 2018-12-31

Alpha-lipoic acid attenuates iron-overload-induced structural changes in the liver of the laboratory mouse (Mus musculus)

William Sibuor [1] , Fidel Gwala [2] , Jeremiah Munguti [3] , Moses Obimbo [4]

47 73

Objectives: The role of alpha-lipoic acid in the amelioration of iron overload-induced hepatic damage remains largely under-explored.  Therefore, this paper aimed at describing the structural effects of alpha lipoic acid on the liver following iron overload in mice.

Methods: After ethical approval, a total of 24 male mice were used. Twenty  mice were randomly divided into 2 groups: A and B. Group A rats received 50mg/kg of iron dextran intraperitoneally daily for 49 days while those in group B received a daily oral dose of 100mg/kg alpha lipoic acid by gavage in addition to the treatment in A. Four mice were used as normal controls. At the endpoint of the experiment, the livers were harvested and studied for iron deposition, parenchymal histoarchitecture and hepatocyte densities. Photomicrographs were taken using a digital photomicroscope for morphometric analysis.
Results: Treatment of mice with iron led to a distortion of the histoarchitecture of the liver which was attenuated with co-administration of alpha lipoic acid. Additionally, co-treatment of iron with alpha lipoic acid resulted in significant lowering of hepatic iron deposition (p<0.001), reduction in leukocyte infiltration and significantly greater hepatocyte densities (p<0.001).

Conclusion: Alpha-lipoic acid appreciably attenuates the structural damage in the liver induced by iron overload.


 



Alpha-lipoic acid, Iron, Liver
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Primary Language en
Subjects Health Care Sciences and Services
Journal Section Original Articles
Authors

Author: William Sibuor (Primary Author)
Institution: University of Nairobi
Country: Kenya


Author: Fidel Gwala
Institution: University of Nairobi
Country: Kenya


Author: Jeremiah Munguti
Institution: University of Nairobi
Country: Kenya


Author: Moses Obimbo
Institution: University of Nairobi
Country: Kenya


Dates

Publication Date: December 31, 2018

Bibtex @research article { anatomy499713, journal = {Anatomy}, issn = {1307-8798}, eissn = {1308-8459}, address = {Turkish Society of Anatomy and Clinical Anatomy (TSACA)}, year = {2018}, volume = {12}, pages = {118 - 123}, doi = {}, title = {Alpha-lipoic acid attenuates iron-overload-induced structural changes in the liver of the laboratory mouse (Mus musculus)}, key = {cite}, author = {Sibuor, William and Gwala, Fidel and Munguti, Jeremiah and Obimbo, Moses} }
APA Sibuor, W , Gwala, F , Munguti, J , Obimbo, M . (2018). Alpha-lipoic acid attenuates iron-overload-induced structural changes in the liver of the laboratory mouse (Mus musculus). Anatomy, 12 (3), 118-123. Retrieved from http://dergipark.org.tr/anatomy/issue/44861/499713
MLA Sibuor, W , Gwala, F , Munguti, J , Obimbo, M . "Alpha-lipoic acid attenuates iron-overload-induced structural changes in the liver of the laboratory mouse (Mus musculus)". Anatomy 12 (2018): 118-123 <http://dergipark.org.tr/anatomy/issue/44861/499713>
Chicago Sibuor, W , Gwala, F , Munguti, J , Obimbo, M . "Alpha-lipoic acid attenuates iron-overload-induced structural changes in the liver of the laboratory mouse (Mus musculus)". Anatomy 12 (2018): 118-123
RIS TY - JOUR T1 - Alpha-lipoic acid attenuates iron-overload-induced structural changes in the liver of the laboratory mouse (Mus musculus) AU - William Sibuor , Fidel Gwala , Jeremiah Munguti , Moses Obimbo Y1 - 2018 PY - 2018 N1 - DO - T2 - Anatomy JF - Journal JO - JOR SP - 118 EP - 123 VL - 12 IS - 3 SN - 1307-8798-1308-8459 M3 - UR - Y2 - 2018 ER -
EndNote %0 Anatomy Alpha-lipoic acid attenuates iron-overload-induced structural changes in the liver of the laboratory mouse (Mus musculus) %A William Sibuor , Fidel Gwala , Jeremiah Munguti , Moses Obimbo %T Alpha-lipoic acid attenuates iron-overload-induced structural changes in the liver of the laboratory mouse (Mus musculus) %D 2018 %J Anatomy %P 1307-8798-1308-8459 %V 12 %N 3 %R %U
ISNAD Sibuor, William , Gwala, Fidel , Munguti, Jeremiah , Obimbo, Moses . "Alpha-lipoic acid attenuates iron-overload-induced structural changes in the liver of the laboratory mouse (Mus musculus)". Anatomy 12 / 3 (December 2019): 118-123.
AMA Sibuor W , Gwala F , Munguti J , Obimbo M . Alpha-lipoic acid attenuates iron-overload-induced structural changes in the liver of the laboratory mouse (Mus musculus). Anat. 2018; 12(3): 118-123.
Vancouver Sibuor W , Gwala F , Munguti J , Obimbo M . Alpha-lipoic acid attenuates iron-overload-induced structural changes in the liver of the laboratory mouse (Mus musculus). Anatomy. 2018; 12(3): 123-118.