Kedi ve Köpeklerde Metisilin Dirençli Staphylococcus pseudintermedius (MRSP) Taşıyıcılığı

Yıl 2019, Cilt: 14 Sayı: 1, 98 - 106, 28.04.2019

Hazel Tamakan Hüban Göçmen

https://doi.org/10.17094/ataunivbd.434642

Öz

Dünya genelinde insan ve hayvanlarda stafilokokal infeksiyonlar giderek yaygınlaşmaktadır. Normal deri florası üyelerinden olan stafilokoklar, fırsatçı patojen olarak çeşitli infeksiyonlara neden olabilmektedir. Fenotipik karakterde Staphylococcus intermedius olarak tanımlanan izolatlar; S. intermedius grubunu (SIG) temsilen S. intermedius, S. pseudintermedius ve S. delphini dahil olmak üzere üç farklı türden oluşmaktadır. Staphylococcus pseudintermedius, nispeten yeni bir tür olup kedi ve köpeklerden sıklıkla izole edilebilmektedir. Yakın zamanda, metisilin dirençli S. pseudintermedius (MRSP) dünya çapında ortaya çıkmış ve yayılımının giderek artmakta olduğu bildirilmiştir. Günümüzün önemli halk sağlığı sorunlarından olan çoklu antibiyotik dirençliliği, yeni kuşak antibiyotiklerin ve kombinasyonlarının kullanımını zorunlu hale getirmiştir. Antibiyotik dirençliliği meydana gelmiş mikroorganizmalar, bugün nozokomiyal ve halk sağlığı ile ilişkili infeksiyonlara neden olabilmektedir. Nitekim bu kapsamda, özellikle metisilin dirençli stafilokok suşları uzun süredir bu infeksiyonların ortaya çıkışında önemli rol oynayarak, birçok hastanın ölümüne neden olabilmektedir. Veteriner hekimlikte sürekli artan antibiyotik kullanımı, antibiyotik dirençliliğinin yayılmasında önemli rol oynamaktadır. Son zamanlarda insan ve hayvanlarda MRSP taşıyıcılığı ile ilgili çalışmalar; MRSP izolasyonundaki artışı ve bu da özellikle pet hayvan sahiplerine bakterinin taşınmasındaki artışı göstermektedir. Uygulanan tedavilerdeki başarısızlık ise; metisilin direncini temsil eden sefoksitin ve oksasilin antibiyotiklerine karşı direçlilik mekanizmasının artışını ifade etmektedir.

Anahtar Kelimeler

Kedi, Köpek, MRSP taşıyıcılığı, Staphylococcus pseudintermedius, Staphylococcus intermedius grup, Staphylococcus pseudintermedius

Transmission of Methicillin Resistant Staphylococcus pseudintermedius (MRSP) in Cats and Dogs

Öz

Staphylococcal infections are increasingly widespread worldwide in humans and animals. Staphylococci, which are members of normal skin flora, can cause various infections as opportunistic pathogens. The isolates identified as Staphylococcus intermedius in phenotypic character; S. intermedius group (SIG) is composed of three different species including S. intermedius, S. pseudintermedius and S. delphini. Staphylococcus pseudintermedius, a relatively new species, is frequently isolated from cats and dogs. Recently, methicillin-resistant S. pseudintermedius (MRSP) has emerged worldwide and has been reported increasingly. Multiple antibiotic resistance, one of the public health problems, has made necessary to use new generation antibiotics and combinations. Today, antibiotic resistance of microorganisms causes nosocomial and public health related infections. Methicillin resistant staphylococci strains have played an important role in the emergence of these infections for a long time and cause many patients to die. The increasing use of antibiotics in veterinary medicine plays an important role in the spread of antibiotic resistance. Recent studies about the carriage of MRSP in humans and animals showed that increase of MRSP isolation and related to high rate of bacterial transmission to pet owners. The failure in applied treatments indicates that increased of resistance mechanism against cefoxitin and oxacillin antibiotics which representing methicillin resistance.

Anahtar Kelimeler

Cat, Dog, Transmission of MRSP, Staphylococcus intermedius group, Staphylococcus pseudintermedius

Kaynakça

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