Year 2017, Volume 18, Issue 5, Pages 962 - 972 2017-12-31

PREPARATION OF A MODIFIED ELECTRODE FOR THE DETERMINATION OF LEVOFLOXACIN

Ayça ATILIR ÖZCAN [1] , Mustafa GÜRBÜZ [2] , Ali ÖZCAN [3]

185 432

In this study, modification of glassy carbon electrode with electrochemically reduced graphene oxide (ERGO) and acid treated multi-walled carbon nanotubes (A-MWCNT) was investigated for the voltammetric determination of LEV in body fluids and pharmaceutical products. Different combinations of GO, ERGO, MWCNT and A-MWCNT were searched and the best results obtained with GC/ERGO/A-MWCNT electrode. The prepared modified electrode showed electrocatalytic acitivity towards LEV oxidation by increasing oxidation peak currents 293 times. Characterizations of the modified electrode was performed with cyclic voltammetry, electrochemical impedance spectroscopy and raman measurements. The highest oxidation peak current was observed at pH value of 2.0. The oxidation peak currents of LEV increased linearly with the concentration of LEV in the range of 0.01 mM and 10 mM. The detection limit of the prepared sensor was determined as 0.0063 mM. After three weeks’ storage, the prepared electrode showed high stability by preserving 93% of its original activity towards 1.0 mM LEV. The prepared electrode successfully discriminates the voltammetric response of LEV from that of other fluoroquinolone antibiotics (enoxacin, norfloxacin, ciprofloxacin). Finally, the performance of the prepared electrode was tested in the determination of LEV in human blood serum, urine and pharmaceutical samples.
Levofloxacin, graphene oxide, multi-walled carbon nanotube, voltammetry, electrochemical sensor
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Subjects Engineering
Journal Section Articles
Authors

Author: Ayça ATILIR ÖZCAN
Institution: ANADOLU UNIVERSITY, FACULTY OF SCIENCE, DEPARTMENT OF CHEMISTRY
Country: Turkey


Author: Mustafa GÜRBÜZ
Institution: Anadolu University, Graduate School of Sciences, Department of Chemistry
Country: Turkey


Author: Ali ÖZCAN
Institution: ANADOLU UNIVERSITY, FACULTY OF SCIENCE, DEPARTMENT OF CHEMISTRY
Country: Turkey


Dates

Publication Date: December 31, 2017

Bibtex @research article { aubtda319445, journal = {ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY A - Applied Sciences and Engineering}, issn = {1302-3160}, eissn = {2146-0205}, address = {Eskişehir Teknik Üniversitesi}, year = {2017}, volume = {18}, pages = {962 - 972}, doi = {10.18038/aubtda.319445}, title = {PREPARATION OF A MODIFIED ELECTRODE FOR THE DETERMINATION OF LEVOFLOXACIN}, key = {cite}, author = {ATILIR ÖZCAN, Ayça and GÜRBÜZ, Mustafa and ÖZCAN, Ali} }
APA ATILIR ÖZCAN, A , GÜRBÜZ, M , ÖZCAN, A . (2017). PREPARATION OF A MODIFIED ELECTRODE FOR THE DETERMINATION OF LEVOFLOXACIN. ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY A - Applied Sciences and Engineering, 18 (5), 962-972. DOI: 10.18038/aubtda.319445
MLA ATILIR ÖZCAN, A , GÜRBÜZ, M , ÖZCAN, A . "PREPARATION OF A MODIFIED ELECTRODE FOR THE DETERMINATION OF LEVOFLOXACIN". ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY A - Applied Sciences and Engineering 18 (2017): 962-972 <http://dergipark.org.tr/aubtda/issue/31308/319445>
Chicago ATILIR ÖZCAN, A , GÜRBÜZ, M , ÖZCAN, A . "PREPARATION OF A MODIFIED ELECTRODE FOR THE DETERMINATION OF LEVOFLOXACIN". ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY A - Applied Sciences and Engineering 18 (2017): 962-972
RIS TY - JOUR T1 - PREPARATION OF A MODIFIED ELECTRODE FOR THE DETERMINATION OF LEVOFLOXACIN AU - Ayça ATILIR ÖZCAN , Mustafa GÜRBÜZ , Ali ÖZCAN Y1 - 2017 PY - 2017 N1 - doi: 10.18038/aubtda.319445 DO - 10.18038/aubtda.319445 T2 - ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY A - Applied Sciences and Engineering JF - Journal JO - JOR SP - 962 EP - 972 VL - 18 IS - 5 SN - 1302-3160-2146-0205 M3 - doi: 10.18038/aubtda.319445 UR - https://doi.org/10.18038/aubtda.319445 Y2 - 2017 ER -
EndNote %0 ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY A - Applied Sciences and Engineering PREPARATION OF A MODIFIED ELECTRODE FOR THE DETERMINATION OF LEVOFLOXACIN %A Ayça ATILIR ÖZCAN , Mustafa GÜRBÜZ , Ali ÖZCAN %T PREPARATION OF A MODIFIED ELECTRODE FOR THE DETERMINATION OF LEVOFLOXACIN %D 2017 %J ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY A - Applied Sciences and Engineering %P 1302-3160-2146-0205 %V 18 %N 5 %R doi: 10.18038/aubtda.319445 %U 10.18038/aubtda.319445
ISNAD ATILIR ÖZCAN, Ayça , GÜRBÜZ, Mustafa , ÖZCAN, Ali . "PREPARATION OF A MODIFIED ELECTRODE FOR THE DETERMINATION OF LEVOFLOXACIN". ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY A - Applied Sciences and Engineering 18 / 5 (December 2018): 962-972. https://doi.org/10.18038/aubtda.319445
AMA ATILIR ÖZCAN A , GÜRBÜZ M , ÖZCAN A . PREPARATION OF A MODIFIED ELECTRODE FOR THE DETERMINATION OF LEVOFLOXACIN. AUJST-A. 2017; 18(5): 962-972.
Vancouver ATILIR ÖZCAN A , GÜRBÜZ M , ÖZCAN A . PREPARATION OF A MODIFIED ELECTRODE FOR THE DETERMINATION OF LEVOFLOXACIN. ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY A - Applied Sciences and Engineering. 2017; 18(5): 972-962.