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Microbiota of the Female Reproductive System

Yıl 2017, - Mikrobiyota, 95 - 103, 15.11.2017

Öz

The detailed evaluation of the members of the vast communities of microorganisms that inhabit our bodies has started with the microbiome project. Therefore, the microorganism fl ora inside the female reproductive system has been examined in terms of reproductive health, pregnancy and newborn health. New data obtained from the evaluation of microorganisms in the female reproductive system by performing studies from a different perspective will help us to understand the contribution of these microorganisms to health and diseases to provide information on future individual therapies. In this review, the effects of the changes in the microbiome of the female reproductive system on infertility, pregnancy and newborn will be evaluated in terms of their potential effects and applications in clinical practice.

Kaynakça

  • 1. Grice EA, Kong HH, Conlan S, Deming CB, Davis J, Young AC; NISC Comparative Sequencing Program, Bouffard GG, Blakesley RW, Murray PR, Green ED, Turner ML, Segre JA. Topographical and temporal diversity of the human skin microbiome. Science. 2009;324(5931):1190-2.
  • 2. Eckburg PB, Bik EM, Bernstein CN, Purdom E, Dethlefsen L, Sargent M, Gill SR, Nelson KE, Relman DA. Diversity of the human intestinal microbial fl ora. Science.2005;308(5728):1635-8.
  • 3. Nasidze I, Li J, Quinque D, Tang K, Stoneking M. Global diversity in the human salivary microbiome. Genome Res. 2009;19(4):636- 43.
  • 4. Oakley BB, Fiedler TL, Marrazzo JM, Fredricks DN. Diversity of Human Vaginal Bacterial Communities and Associations with Clinically Defi ned Bacterial Vaginosis. Applied and Environmental Microbiology. 2008;74(15):4898-4909.
  • 5. Relman DA. The Human Microbiome and the Future Practice of Medicine. JAMA. 2015;314(11):1127-8.
  • 6. Ravel J, Gajer P, Abdo Z, Schneider GM, Koenig SS, McCulle SL, Karlebach S, Gorle R, Russell J, Tacket CO, Brotman RM, Davis CC, Ault K, Peralta L, Forney LJ. Vaginal microbiome of reproductive-age women. Proc Natl Acad Sci USA. 2011;108 Suppl 1:4680-7.
  • 7. Priestley CJ, Jones BM, Dhar J, Goodwin L. What is normal vaginal fl ora? Genitourin Med. 1997;73(1):23-8.
  • 8. Schwebke JR, Richey CM, Weiss2 HL. Correlation of behaviors with microbiological changes in vaginal fl ora. J Infect Dis. 1999;180(5):1632-6.
  • 9. Mirmonsef P, Hotton AL, Gilbert D, Gioia CJ, Maric D, Hope TJ, Landay AL, Spear GT. Glycogen Levels in Undiluted Genital Fluid and Their Relationship to Vaginal pH, Estrogen, and Progesterone. PLoS One. 2016;11(4):e0153553.
  • 10. Hickey RJ, Zhou X, Settles ML, Erb J, Malone K, Hansmann MA, Shew ML, Van Der Pol B, Fortenberry JD, Forney LJ. Vaginal microbiota of adolescent girls prior to the onset of menarche resemble those of reproductive-age women. MBio. 2015;6(2).
  • 11. Eschenbach DA, Thwin SS, Patton DL, Hooton TM, Stapleton AE, Agnew K, Winter C, Meier A, Stamm WE. Infl uence of the normal menstrual cycle on vaginal tissue, discharge, and microfl ora. Clin Infect Dis. 2000;30(6):901-7.
  • 12. Brotman RM, Shardell MD, Gajer P, Fadrosh D, Chang K, Silver MI, Viscidi RP, Burke AE, Ravel J, Gravitt PE. Association between the vaginal microbiota, menopause status, and signs of vulvovaginal atrophy. Menopause. 2014;21(5):450-8.
  • 13. Borges S, Silva J, Teixeira P. The role of lactobacilli and probiotics in maintaining vaginal health. Arch Gynecol Obstet. 2014;289(3):479- 89.Review.
  • 14. Machado A, Salgueiro D, Harwich M, Jefferson KK, Cerca N. Quantitative analysis of initial adhesion of bacterial vaginosisassociated anaerobes to ME-180 cells. Anaerobe. 2013;23:1-4.
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Kadın Üreme Sistemi Mikrobiyotası

Yıl 2017, - Mikrobiyota, 95 - 103, 15.11.2017

Öz

Mikrobiyom projesi ile vücudumuzdaki büyük mikroorganizma fl orası üyelerinin detaylandırılması yapılmaya başlanmıştır. Bu bağlamda kadın üreme sisteminde yer alan mikroorganizma fl orası da üreme sağlığı, gebelik ve yenidoğan sağlığı yönünden yeniden ele alınmıştır. Kadın üreme sistemindeki mikroorganizmaların farklı bakış açısıyla incelenmesiyle yapılan araştırmalar sayesinde, elde olunan yeni bilgilerin bireylerde sağlık ve hastalık oluşumuna katkıları ve gelecekte buna yönelik yeni tedavi yöntemlerinin planlanması mümkün olabilecektir. Derlemede kadın üreme sistemi mikrobiyomunda saptanan değişimlerin infertilite, gebelik ve yenidoğan yönünden olası potansiyel etkilerinden ve klinik pratiğindeki uygulamalarından bahsedilecektir.

Kaynakça

  • 1. Grice EA, Kong HH, Conlan S, Deming CB, Davis J, Young AC; NISC Comparative Sequencing Program, Bouffard GG, Blakesley RW, Murray PR, Green ED, Turner ML, Segre JA. Topographical and temporal diversity of the human skin microbiome. Science. 2009;324(5931):1190-2.
  • 2. Eckburg PB, Bik EM, Bernstein CN, Purdom E, Dethlefsen L, Sargent M, Gill SR, Nelson KE, Relman DA. Diversity of the human intestinal microbial fl ora. Science.2005;308(5728):1635-8.
  • 3. Nasidze I, Li J, Quinque D, Tang K, Stoneking M. Global diversity in the human salivary microbiome. Genome Res. 2009;19(4):636- 43.
  • 4. Oakley BB, Fiedler TL, Marrazzo JM, Fredricks DN. Diversity of Human Vaginal Bacterial Communities and Associations with Clinically Defi ned Bacterial Vaginosis. Applied and Environmental Microbiology. 2008;74(15):4898-4909.
  • 5. Relman DA. The Human Microbiome and the Future Practice of Medicine. JAMA. 2015;314(11):1127-8.
  • 6. Ravel J, Gajer P, Abdo Z, Schneider GM, Koenig SS, McCulle SL, Karlebach S, Gorle R, Russell J, Tacket CO, Brotman RM, Davis CC, Ault K, Peralta L, Forney LJ. Vaginal microbiome of reproductive-age women. Proc Natl Acad Sci USA. 2011;108 Suppl 1:4680-7.
  • 7. Priestley CJ, Jones BM, Dhar J, Goodwin L. What is normal vaginal fl ora? Genitourin Med. 1997;73(1):23-8.
  • 8. Schwebke JR, Richey CM, Weiss2 HL. Correlation of behaviors with microbiological changes in vaginal fl ora. J Infect Dis. 1999;180(5):1632-6.
  • 9. Mirmonsef P, Hotton AL, Gilbert D, Gioia CJ, Maric D, Hope TJ, Landay AL, Spear GT. Glycogen Levels in Undiluted Genital Fluid and Their Relationship to Vaginal pH, Estrogen, and Progesterone. PLoS One. 2016;11(4):e0153553.
  • 10. Hickey RJ, Zhou X, Settles ML, Erb J, Malone K, Hansmann MA, Shew ML, Van Der Pol B, Fortenberry JD, Forney LJ. Vaginal microbiota of adolescent girls prior to the onset of menarche resemble those of reproductive-age women. MBio. 2015;6(2).
  • 11. Eschenbach DA, Thwin SS, Patton DL, Hooton TM, Stapleton AE, Agnew K, Winter C, Meier A, Stamm WE. Infl uence of the normal menstrual cycle on vaginal tissue, discharge, and microfl ora. Clin Infect Dis. 2000;30(6):901-7.
  • 12. Brotman RM, Shardell MD, Gajer P, Fadrosh D, Chang K, Silver MI, Viscidi RP, Burke AE, Ravel J, Gravitt PE. Association between the vaginal microbiota, menopause status, and signs of vulvovaginal atrophy. Menopause. 2014;21(5):450-8.
  • 13. Borges S, Silva J, Teixeira P. The role of lactobacilli and probiotics in maintaining vaginal health. Arch Gynecol Obstet. 2014;289(3):479- 89.Review.
  • 14. Machado A, Salgueiro D, Harwich M, Jefferson KK, Cerca N. Quantitative analysis of initial adhesion of bacterial vaginosisassociated anaerobes to ME-180 cells. Anaerobe. 2013;23:1-4.
  • 15. Mastromarino P, Brigidi P, Macchia S, Maggi L, Pirovano F, Trinchieri V, Conte U, Matteuzzi D. Characterization and selection of vaginal Lactobacillus strains for the preparation of vaginal tablets. J Appl Microbiol. 2002;93(5):884-93.
  • 16. Boskey ER, Cone RA, Whaley KJ, Moench TR. Origins of vaginal acidity: high D/L lactate ratio is consistent with bacteria being the primary source. Hum Reprod.2001;16(9):1809-13.
  • 17. Aroutcheva A, Gariti D, Simon M, Shott S, Faro J, Simoes JA, Gurguis A, Faro S. Defense factors of vaginal lactobacilli. Am J Obstet Gynecol. 2001;185(2):375-9.
  • 18. Machado D, Castro J, Palmeira-de-Oliveira A, Martinez-de-Oliveira J, Cerca N.Bacterial Vaginosis Biofi lms: Challenges to Current Therapies and Emerging Solutions. Front Microbiol. 2016;6:1528.
  • 19. Nelson DB, Hanlon A, Nachamkin I, Haggerty C, Mastrogiannis DS, Liu C,Fredricks DN. Early pregnancy changes in bacterial vaginosis-associated bacteria and preterm delivery. Paediatr Perinat Epidemiol. 2014;28(2):88-96.
  • 20. Kenyon C, Colebunders R, Crucitti T. The global epidemiology of bacterial vaginosis: a systematic review. Am J Obstet Gynecol. 2013 Dec;209(6):505-23.
  • 21. Taylor BD, Darville T, Haggerty CL. Does bacterial vaginosis cause pelvic infl ammatory disease? Sex Transm Dis. 2013 Feb;40(2):117- 22.
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  • 89. Martin R, Langa S, Reviriego C, Jiminez E, Marin ML, Xaus J, Fernandez L,Rodriguez JM. Human milk is a source of lactic acid bacteria for the infant gut. J Pediatr. 2003;143(6):754–8.
Toplam 89 adet kaynakça vardır.

Ayrıntılar

Konular Sağlık Kurumları Yönetimi
Bölüm Derleme
Yazarlar

Hilal Uslu Yuvacı Bu kişi benim

A. Serhan Cevrioğlu

Yayımlanma Tarihi 15 Kasım 2017
Kabul Tarihi 1 Eylül 2017
Yayımlandığı Sayı Yıl 2017 - Mikrobiyota

Kaynak Göster

AMA Uslu Yuvacı H, Cevrioğlu AS. Microbiota of the Female Reproductive System. J Biotechnol and Strategic Health Res. Kasım 2017;1:95-103.
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