Determination of Olanzapine in Pharmaceutical Preparations by Linear Sweep Voltammetry Method

Yıl 2017, Cilt: 13 Sayı: 1, 99 - 104, 29.03.2017

Bilal Yılmaz Mevlüt Albayrak Yücel Kadıoğlu

https://doi.org/10.18466/cbayarfbe.302648

Cited By: 2

Öz

In
this study, simple and fast linear sweep voltammetry method was developed and
validated for determination of olanzapine in pharmaceutical preparations. The
proposed method was based on electrochemical oxidation of olanzapine on glassy
carbon electrode in solution containing 0.04 M Britton-Robinson buffer of pH
1.65. The well-defined an oxidation peak was observed at 1.06 V.  The calibration curve was linear for
olanzapine at the concentration range of 2.5-50 µg/mL for linear sweep
voltammetry method. Intra- and inter-day precision values for olanzapine were
less than 4.78, and accuracy (relative error) was better than 1.85%. The limits
of detection and quantification of olanzapine were 0.50 and 1.50 μg/mL,
respectively. The mean recovery of olanzapine was 99.8% for pharmaceutical
preparations. Stability measurements were carried out with linear sweep
voltammetry method. The results were evaluated comparing these measurements
with those of standards and expressed as percentage deviation and olanzapine
was found as stable at room temperature, 4 and -20 °C for at least 72 h. No
interference was found excipient at the selected assay conditions. The
voltammetric run time of 1 min allows the analysis of a large number of samples
in a short period of time. The proposed method is highly sensitive, precise and
accurate and can be used for the reliable quantitation of olanzapine in
pharmaceutical dosage form

Anahtar Kelimeler

Cyclic voltammetry, Linear sweep voltammetry, Olanzapine, Validation

Kaynakça

• Biryol, I., Erk, N. Voltammetric, spectrophotometric, and high performance liquid chromatographic analysis of olanzapine. Analytical Letters. 2003; 36, 2497-2513.