Year 2017, Volume 13, Issue 1, Pages 99 - 104 2017-03-29

Determination of Olanzapine in Pharmaceutical Preparations by Linear Sweep Voltammetry Method

Bilal Yılmaz [1] , Mevlüt Albayrak [2] , Yücel Kadıoğlu [3]

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In this study, simple and fast linear sweep voltammetry method was developed and validated for determination of olanzapine in pharmaceutical preparations. The proposed method was based on electrochemical oxidation of olanzapine on glassy carbon electrode in solution containing 0.04 M Britton-Robinson buffer of pH 1.65. The well-defined an oxidation peak was observed at 1.06 V.  The calibration curve was linear for olanzapine at the concentration range of 2.5-50 µg/mL for linear sweep voltammetry method. Intra- and inter-day precision values for olanzapine were less than 4.78, and accuracy (relative error) was better than 1.85%. The limits of detection and quantification of olanzapine were 0.50 and 1.50 μg/mL, respectively. The mean recovery of olanzapine was 99.8% for pharmaceutical preparations. Stability measurements were carried out with linear sweep voltammetry method. The results were evaluated comparing these measurements with those of standards and expressed as percentage deviation and olanzapine was found as stable at room temperature, 4 and -20 °C for at least 72 h. No interference was found excipient at the selected assay conditions. The voltammetric run time of 1 min allows the analysis of a large number of samples in a short period of time. The proposed method is highly sensitive, precise and accurate and can be used for the reliable quantitation of olanzapine in pharmaceutical dosage form

Cyclic voltammetry, Linear sweep voltammetry, Olanzapine, Validation
  • Biryol, I., Erk, N. Voltammetric, spectrophotometric, and high performance liquid chromatographic analysis of olanzapine. Analytical Letters. 2003; 36, 2497-2513.
Subjects Engineering
Journal Section Articles
Authors

Author: Bilal Yılmaz

Author: Mevlüt Albayrak

Author: Yücel Kadıoğlu

Bibtex @research article { cbayarfbe302648, journal = {Celal Bayar University Journal of Science}, issn = {1305-130X}, eissn = {1305-1385}, address = {Celal Bayar University}, year = {2017}, volume = {13}, pages = {99 - 104}, doi = {10.18466/cbayarfbe.302648}, title = {Determination of Olanzapine in Pharmaceutical Preparations by Linear Sweep Voltammetry Method}, key = {cite}, author = {Yılmaz, Bilal and Albayrak, Mevlüt and Kadıoğlu, Yücel} }
APA Yılmaz, B , Albayrak, M , Kadıoğlu, Y . (2017). Determination of Olanzapine in Pharmaceutical Preparations by Linear Sweep Voltammetry Method. Celal Bayar University Journal of Science, 13 (1), 99-104. DOI: 10.18466/cbayarfbe.302648
MLA Yılmaz, B , Albayrak, M , Kadıoğlu, Y . "Determination of Olanzapine in Pharmaceutical Preparations by Linear Sweep Voltammetry Method". Celal Bayar University Journal of Science 13 (2017): 99-104 <http://dergipark.org.tr/cbayarfbe/issue/28447/302648>
Chicago Yılmaz, B , Albayrak, M , Kadıoğlu, Y . "Determination of Olanzapine in Pharmaceutical Preparations by Linear Sweep Voltammetry Method". Celal Bayar University Journal of Science 13 (2017): 99-104
RIS TY - JOUR T1 - Determination of Olanzapine in Pharmaceutical Preparations by Linear Sweep Voltammetry Method AU - Bilal Yılmaz , Mevlüt Albayrak , Yücel Kadıoğlu Y1 - 2017 PY - 2017 N1 - doi: 10.18466/cbayarfbe.302648 DO - 10.18466/cbayarfbe.302648 T2 - Celal Bayar University Journal of Science JF - Journal JO - JOR SP - 99 EP - 104 VL - 13 IS - 1 SN - 1305-130X-1305-1385 M3 - doi: 10.18466/cbayarfbe.302648 UR - https://doi.org/10.18466/cbayarfbe.302648 Y2 - 2019 ER -
EndNote %0 Celal Bayar University Journal of Science Determination of Olanzapine in Pharmaceutical Preparations by Linear Sweep Voltammetry Method %A Bilal Yılmaz , Mevlüt Albayrak , Yücel Kadıoğlu %T Determination of Olanzapine in Pharmaceutical Preparations by Linear Sweep Voltammetry Method %D 2017 %J Celal Bayar University Journal of Science %P 1305-130X-1305-1385 %V 13 %N 1 %R doi: 10.18466/cbayarfbe.302648 %U 10.18466/cbayarfbe.302648
ISNAD Yılmaz, Bilal , Albayrak, Mevlüt , Kadıoğlu, Yücel . "Determination of Olanzapine in Pharmaceutical Preparations by Linear Sweep Voltammetry Method". Celal Bayar University Journal of Science 13 / 1 (March 2017): 99-104. https://doi.org/10.18466/cbayarfbe.302648