Year 2017, Volume 13, Issue 4, Pages 919 - 923 2017-12-29

Genotoxic Effects of Aluminium Acetate by Micronucleus Assay

Yasin Eren [1] , Dilek Akyıl [2] , Arzu Özkara [3]

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Aluminium, the mostly used element in the world, and its usage is increasing in many applications. Aluminium acetate (AA) has been used in many therapeutical applications, too. Because of widely usage of AA in medicine, its safety must be clearly defined. This research evaluated the genotoxic effects of AA. It has been known that aluminium had very important toxic effect in long time exposures. It was aimed to determine if AA had same genotoxic effects or not. Genotoxic effects of AA were determined with human lymphocytes MN assay. Control, Negative control (1% DMSO), positive control (MMC, 0.20 µg/ml), 1250, 2500, 5000, 10000, and 15000 ppm doses of AA were used in this assay. MNBC % and NDI values of AA were compared with negative control group. 15000 ppm of AA were observed as EC50 concentration that reduced the mitotic index about 50 %. As a result of MNBC %,  there was statistically significant increase in MN frequency at 5000 and 10000 ppm doses.  Dose-dependent cytotoxicity were obtained from NDI study. The highest MN frequency and the lowest NDI frequency were obtained from 10000 ppm at 48 h treatment while the lowest MN and the highest NDI frequencies were determined in 1250 ppm at 24 h treatment. This research showed that used concentrations did not produce significant MN frequency but significantly reduced the NDI value when compared to MMC. 

Aluminium acetate, MN assay, MNBC, NDI
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Subjects Engineering
Journal Section Articles
Authors

Author: Yasin Eren
Country: Turkey


Author: Dilek Akyıl
Country: Turkey


Author: Arzu Özkara
Country: Turkey


Bibtex @research article { cbayarfbe319416, journal = {Celal Bayar University Journal of Science}, issn = {1305-130X}, eissn = {1305-1385}, address = {Celal Bayar University}, year = {2017}, volume = {13}, pages = {919 - 923}, doi = {10.18466/cbayarfbe.319416}, title = {Genotoxic Effects of Aluminium Acetate by Micronucleus Assay}, key = {cite}, author = {Eren, Yasin and Akyıl, Dilek and Özkara, Arzu} }
APA Eren, Y , Akyıl, D , Özkara, A . (2017). Genotoxic Effects of Aluminium Acetate by Micronucleus Assay. Celal Bayar University Journal of Science, 13 (4), 919-923. Retrieved from http://dergipark.org.tr/cbayarfbe/issue/33464/319416
MLA Eren, Y , Akyıl, D , Özkara, A . "Genotoxic Effects of Aluminium Acetate by Micronucleus Assay". Celal Bayar University Journal of Science 13 (2017): 919-923 <http://dergipark.org.tr/cbayarfbe/issue/33464/319416>
Chicago Eren, Y , Akyıl, D , Özkara, A . "Genotoxic Effects of Aluminium Acetate by Micronucleus Assay". Celal Bayar University Journal of Science 13 (2017): 919-923
RIS TY - JOUR T1 - Genotoxic Effects of Aluminium Acetate by Micronucleus Assay AU - Yasin Eren , Dilek Akyıl , Arzu Özkara Y1 - 2017 PY - 2017 N1 - DO - T2 - Celal Bayar University Journal of Science JF - Journal JO - JOR SP - 919 EP - 923 VL - 13 IS - 4 SN - 1305-130X-1305-1385 M3 - UR - Y2 - 2017 ER -
EndNote %0 Celal Bayar University Journal of Science Genotoxic Effects of Aluminium Acetate by Micronucleus Assay %A Yasin Eren , Dilek Akyıl , Arzu Özkara %T Genotoxic Effects of Aluminium Acetate by Micronucleus Assay %D 2017 %J Celal Bayar University Journal of Science %P 1305-130X-1305-1385 %V 13 %N 4 %R %U
ISNAD Eren, Yasin , Akyıl, Dilek , Özkara, Arzu . "Genotoxic Effects of Aluminium Acetate by Micronucleus Assay". Celal Bayar University Journal of Science 13 / 4 (December 2017): 919-923.