Year 2019, Volume 40, Issue 1, Pages 136 - 140 2019-03-22

Determination of Glutathione Reductase Activity Changes Exposed to Some 2-Aminothiazole Derivatives
Bazı 2-aminotiazol Türevlerine Maruz Kalmış Glutatyon Redüktaz Aktivitesindeki Değişimlerinin Belirlenmesi

Hasan KARADAĞ [1] , Emine EROĞLU [2] , Cumhur KIRILMIŞ [3]

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In this work, effects of concentrations ranging from 0 to 500 mg/L of some 2-aminothiazole derivatives such as 4,4’-(disulfanediylbis(methylene))bis(thiazol-2-amine) dihyrochloride (DMTA) and 2-amino-4-(chloromethyl)thiazole hydrochloride (ACT) on glutathione reductase from baker's yeast (Saccharomyces cerevisiae) (GR) were investigated. With exposure of 25, 50, 100, 250 and 500 mg/L concentrations, % GR activity changes were calculated as -5.29 ; -3.85 ; -2.40 ; -6.73 and -10.58 in DMTA applications, while these changes were calculated as +0.98 ; 0.00 ; -0.49 ; -2.45 and 0.00  in ACT applications, respectively. This work indicated that there was a slight decrease in GR activity with the increase of DMTA concentrations and there was no significant change in GR activity with the increase of ACT concentrations.  But according to control activities, no statitistical changes were observed in GR activities with exposure of these 2-aminothiazole derivatives (p > 0.05, n=3).

Bu çalışmada, 2-Aminotiazol türevleri olan 4,4’-(disulfanediylbis(methylene))bis(thiazol-2-amine) dihyrochloride (DMTA) ve 2-amino-4-(chloromethyl)thiazole hydrochloride (ACT)’in 0 dan 500 mg/L ye değişen derişimlerinin ekmek mayası (Saccharomyces cerevisiae) glutatyon redüktazı (GR) üzerine olan etkileri araştırılmıştır. 25, 50, 100, 250 ve 500 mg/L derişimlere maruz bırakılma ile % GR aktivitesindeki değişimler, DMTA uygulamalarında sırasıyla -5,29 ; -3,85; -2,40 ; -6,73 ve -10,58 olarak hesaplanırken, ACT uygulamalarında sırasıyla +0,98; 0,00; -0,49; -2,45 ve 0,00 olarak hesaplanmıştır. Bu çalışma, DMTA derişimlerinin artışı ile GR aktivitesinde hafif bir düşüş olduğunu ve ACT derişimlerinin artışı ile GR aktivitesinde önemli bir değişimin olmadığını göstermiştir. Ancak kontrol aktivitelerine göre, bu 2-aminotiazol türevlerinin etkileştiği GR aktivitelerinde herhangi bir istatistiksel değişim gözlemlenmemiştir   (p >  0,05, n = 3).

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Primary Language en
Subjects Basic Sciences
Journal Section Natural Sciences
Authors

Orcid: 0000-0001-5701-8445
Author: Hasan KARADAĞ (Primary Author)
Institution: ADIYAMAN UNIVERSITY
Country: Turkey


Orcid: 0000-0002-1543-3381
Author: Emine EROĞLU
Institution: ADIYAMAN UNIVERSITY
Country: Turkey


Orcid: 0000-0002-9190-4800
Author: Cumhur KIRILMIŞ
Institution: ADIYAMAN UNIVERSITY
Country: Turkey


Bibtex @research article { csj504690, journal = {Cumhuriyet Science Journal}, issn = {2587-2680}, eissn = {2587-246X}, address = {Cumhuriyet University}, year = {2019}, volume = {40}, pages = {136 - 140}, doi = {10.17776/csj.504690}, title = {Determination of Glutathione Reductase Activity Changes Exposed to Some 2-Aminothiazole Derivatives}, key = {cite}, author = {KARADAĞ, Hasan and EROĞLU, Emine and KIRILMIŞ, Cumhur} }
APA KARADAĞ, H , EROĞLU, E , KIRILMIŞ, C . (2019). Determination of Glutathione Reductase Activity Changes Exposed to Some 2-Aminothiazole Derivatives. Cumhuriyet Science Journal, 40 (1), 136-140. DOI: 10.17776/csj.504690
MLA KARADAĞ, H , EROĞLU, E , KIRILMIŞ, C . "Determination of Glutathione Reductase Activity Changes Exposed to Some 2-Aminothiazole Derivatives". Cumhuriyet Science Journal 40 (2019): 136-140 <http://dergipark.org.tr/csj/issue/43798/504690>
Chicago KARADAĞ, H , EROĞLU, E , KIRILMIŞ, C . "Determination of Glutathione Reductase Activity Changes Exposed to Some 2-Aminothiazole Derivatives". Cumhuriyet Science Journal 40 (2019): 136-140
RIS TY - JOUR T1 - Determination of Glutathione Reductase Activity Changes Exposed to Some 2-Aminothiazole Derivatives AU - Hasan KARADAĞ , Emine EROĞLU , Cumhur KIRILMIŞ Y1 - 2019 PY - 2019 N1 - doi: 10.17776/csj.504690 DO - 10.17776/csj.504690 T2 - Cumhuriyet Science Journal JF - Journal JO - JOR SP - 136 EP - 140 VL - 40 IS - 1 SN - 2587-2680-2587-246X M3 - doi: 10.17776/csj.504690 UR - https://doi.org/10.17776/csj.504690 Y2 - 2019 ER -
EndNote %0 Cumhuriyet Science Journal Determination of Glutathione Reductase Activity Changes Exposed to Some 2-Aminothiazole Derivatives %A Hasan KARADAĞ , Emine EROĞLU , Cumhur KIRILMIŞ %T Determination of Glutathione Reductase Activity Changes Exposed to Some 2-Aminothiazole Derivatives %D 2019 %J Cumhuriyet Science Journal %P 2587-2680-2587-246X %V 40 %N 1 %R doi: 10.17776/csj.504690 %U 10.17776/csj.504690
ISNAD KARADAĞ, Hasan , EROĞLU, Emine , KIRILMIŞ, Cumhur . "Determination of Glutathione Reductase Activity Changes Exposed to Some 2-Aminothiazole Derivatives". Cumhuriyet Science Journal 40 / 1 (March 2019): 136-140. https://doi.org/10.17776/csj.504690