Curcumin-Loaded Bio-Based Electrospun Polyurethane Scaffolds

Yıl 2019, Cilt: 40 Sayı: 1, 125 - 135, 22.03.2019

Nesrin Horzum Polat Nehir Arık Kınalı

https://doi.org/10.17776/csj.505746

Cited By: 7

Öz

Polymeric
electrospun fibers present well-design scaffolds for wound healing
applications. Here, the fabrication of biobased polyurethane (PU) blend fibers
containing curcumin (Cur) was reported. Not only polymer concentration but also
curcumin concentration affects the morphology, diameter, and contact angle
values of the fibers. Morphological investigations revealed that the diameter
and hydrophilicity of the PU fibers increased upon addition of curcumin. Effect
of process parameters (applied voltage, flow rate, and tip-to-collector
distance) on the average diameter and the hydrophilicity of the PU and PU/Cur
fibers were examined. Optimum conditions to obtain uniform and bead-free PU/Cur
fibers were determined as 12.5 kV, 1
mL/h, and 17 cm. This study demonstrates that the electrospinning process
provides a simple way of obtaining bioactive agent loaded fibrous scaffolds, as
well as contributing to a better understanding of the effect of process
variables in the fabrication of PU/Cur blend fibers for wound healing
applications.

Anahtar Kelimeler

bio-based polyurethane, curcumin, electrospinning, fibers, Biomaterials, wound healing

Kurkumin Yüklü Biyo-Bazlı Elektroeğirme Poliüretan Yapılar

Öz

Polimerik
elektroeğirme lifler, yara iyileşme uygulamaları için iyi tasarımlı iskeleler
sunmaktadır. Burada, kurkumin (Cur) içeren biyobazlı poliüretan (PU) karışım
liflerin üretimi rapor edilmektedir. Yalnızca
polimer konsantrasyonu değil, aynı zamanda kurkumin konsantrasyonu, fiberlerin
morfolojisi, çapı ve temas açısı değerlerini etkilemiştir. Morfolojik
araştırmalar, PU liflerinin çapının ve hidrofilikliğinin kurkumin ilavesi
üzerine arttığını ortaya koymuştur. Proses parametrelerinin (uygulanan voltaj,
akış hızı ve uçtan toplayıcıya mesafe) PU ve PU/Cur liflerinin ortalama çap ve
hidrofilikliği üzerindeki etkileri incelenmiştir. Homojen ve boncuksuz PU/Cur
lif elde etmek için optimum koşullar 12.5 kV, 1 mL/s ve 17 cm olarak
belirlenmiştir. Bu çalışma, elektroeğirme işleminin, biyoaktif madde yüklü
lifli iskeleleri elde etmenin basit bir yolunu sağlamasının yanı sıra, PU/Cur
karışım liflerinin imalatında yara iyileşmesi uygulamaları için işlem
değişkenlerinin etkisinin daha iyi anlaşılmasına katkıda bulunduğunu
göstermektedir.

Anahtar Kelimeler

biyo-tabanlı poliüretan, kurkumin, elektroeğirme, lifler, Biyomalzemeler, yara iyileşmesi

Kaynakça

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