Year 2018, Volume 1, Issue 2, Pages 117 - 119 2018-12-31

Neutalizants for Antimicrobial Effective Preservatives in Microbiological Analysis in Cosmetic Products

Gökhan CENGİZ [1] , Evren ALGIN YAPAR [2]

46 194

Blue and green cosmetics are sensitive products for microbial contamination and reducing the contamination producing according to Cosmetic Good Manufacturing Practice (ISO 22716), providing proper storage condition and packaging  are effective factors. In addition antimicrobial effective preservatives can be added to protect the cosmetic products.1,2 Generally, preservatives are chemical substrates that are effective on cytoplasm (conjugation mechanism, ribosomes, nucleic acids, thiol groups, amino groups), cell wall and cytoplasm membrane (membrane potential, enzymes, membrane penetration).3 The neutralization of the antimicrobial effect of the preservatives in microbiological quality control of cosmetics is essential for the safety of the tests. The antimicrobial preservative in the cosmetic which is transferred to the medium affects the test negatively. The neutralization process can be carried out according to international standards used in microbiological analysis of cosmetic products. The neutralization of preservatives in cosmetics can be performed by adding of neutralizing agents in solvent, medium and/or washing solution. The agents which are reacted with the preservative groups for the removal of antimicrobial affect are used for this neutralization process which is necessary for the removal of antimicrobial effect. According to European Pharmacopeia 2.6.12. sodium bisulfite for glutaraldehyde and mercury compounds; dilution for sorbates and aldehydes; lecithin, polysorbate 80, saponin for quaternary ammonium compounds, parabens and iodines; thioglycollate for mercurial; thiosulfate for halogens can be used as neutralizing agents.4 Lecithin, polysorbate 80 for parabens, phenoxyethanol, phenylethanol; Lecithin, saponin, polysorbate 80, sodium dodecyl sulphate for quaternary ammonium compounds and cationic surfactants; glycine, histidine for aldehydes formaldehyde-release agents; sodium thiosulphate for oxidizing agents; sodium bisulphate, L-cysteine and thioglycollic acid for metallic salts can be added to the medium, solvent and/or washing solutions according to ISO 21149.5 For the removal of antimicrobial effect, neutralizing agents in proper concentrations should be added to medium, solvents and washing solutions. The addition of these agents with antimicrobial effect should be proved by the studies of conformity. Neutralizing agents react with antimicrobial agents to eliminate the antimicrobial effect.

Cosmetic product, Microbiological control, Neutralization, Neutralizing agents
  • 1. Republic Turkey Ministry of Health. Turkish Medicines And Medical Devices Agency Cosmetic Law, 2005, No, 25823.
  • 2. ISO 22716, Cosmetics - Good Manufacturing Practices (GMP) - Guidelines on Good Manufacturing Practices, 2013.
  • 3. ISO 17516, Cosmetic microbiology microbiological limits, 2014.
  • 4. European Pharmacopoeia 9.0, 2.6.12. Microbiological exaimination of non-sterile products: microbial enumeration tests, 2017.
  • 5. ISO 21149, Cosmetic microbiology enumeration and detection of aerobic mesophilic bacteria, 2006.
Primary Language en
Subjects Science
Journal Section Articles
Authors

Orcid: 0000-0002-8275-8549
Author: Gökhan CENGİZ
Institution: Türkiye İlaç ve Tıbbi Cihaz Kurumu
Country: Turkey


Orcid: 0000-0002-6504-4608
Author: Evren ALGIN YAPAR (Primary Author)
Institution: Türkiye İlaç ve Tıbbi Cihaz Kurumu
Country: Turkey


Dates

Publication Date: December 31, 2018

Bibtex @review { cupmap480122, journal = {Current Perspectives on Medicinal and Aromatic Plants (CUPMAP)}, issn = {2619-9645}, eissn = {2667-5722}, address = {Nazım ŞEKEROĞLU}, year = {2018}, volume = {1}, pages = {117 - 119}, doi = {}, title = {Neutalizants for Antimicrobial Effective Preservatives in Microbiological Analysis in Cosmetic Products}, key = {cite}, author = {CENGİZ, Gökhan and ALGIN YAPAR, Evren} }
APA CENGİZ, G , ALGIN YAPAR, E . (2018). Neutalizants for Antimicrobial Effective Preservatives in Microbiological Analysis in Cosmetic Products. Current Perspectives on Medicinal and Aromatic Plants (CUPMAP), 1 (2), 117-119. Retrieved from http://dergipark.org.tr/cupmap/issue/41942/480122
MLA CENGİZ, G , ALGIN YAPAR, E . "Neutalizants for Antimicrobial Effective Preservatives in Microbiological Analysis in Cosmetic Products". Current Perspectives on Medicinal and Aromatic Plants (CUPMAP) 1 (2018): 117-119 <http://dergipark.org.tr/cupmap/issue/41942/480122>
Chicago CENGİZ, G , ALGIN YAPAR, E . "Neutalizants for Antimicrobial Effective Preservatives in Microbiological Analysis in Cosmetic Products". Current Perspectives on Medicinal and Aromatic Plants (CUPMAP) 1 (2018): 117-119
RIS TY - JOUR T1 - Neutalizants for Antimicrobial Effective Preservatives in Microbiological Analysis in Cosmetic Products AU - Gökhan CENGİZ , Evren ALGIN YAPAR Y1 - 2018 PY - 2018 N1 - DO - T2 - Current Perspectives on Medicinal and Aromatic Plants (CUPMAP) JF - Journal JO - JOR SP - 117 EP - 119 VL - 1 IS - 2 SN - 2619-9645-2667-5722 M3 - UR - Y2 - 2018 ER -
EndNote %0 Current Perspectives on Medicinal and Aromatic Plants (CUPMAP) Neutalizants for Antimicrobial Effective Preservatives in Microbiological Analysis in Cosmetic Products %A Gökhan CENGİZ , Evren ALGIN YAPAR %T Neutalizants for Antimicrobial Effective Preservatives in Microbiological Analysis in Cosmetic Products %D 2018 %J Current Perspectives on Medicinal and Aromatic Plants (CUPMAP) %P 2619-9645-2667-5722 %V 1 %N 2 %R %U
ISNAD CENGİZ, Gökhan , ALGIN YAPAR, Evren . "Neutalizants for Antimicrobial Effective Preservatives in Microbiological Analysis in Cosmetic Products". Current Perspectives on Medicinal and Aromatic Plants (CUPMAP) 1 / 2 (December 2019): 117-119.
AMA CENGİZ G , ALGIN YAPAR E . Neutalizants for Antimicrobial Effective Preservatives in Microbiological Analysis in Cosmetic Products. CUPMAP. 2018; 1(2): 117-119.
Vancouver CENGİZ G , ALGIN YAPAR E . Neutalizants for Antimicrobial Effective Preservatives in Microbiological Analysis in Cosmetic Products. Current Perspectives on Medicinal and Aromatic Plants (CUPMAP). 2018; 1(2): 119-117.