Year 2019, Volume 7, Issue 3, Pages 1755 - 1763 2019-07-31

Lamium purpureum L.’nin Kimyasal Bileşimi ve Uçucu Yağının İnsan Melanom Kanseri Üzerine Antikanser Aktivitesinin Belirlenmesi
Chemical Composition of Lamium purpureum L. and Determination of Anticancer Activity of Its Essential Oil on Melanoma

Ayşegül Akkoyunlu [1] , Gorkem Dulger [2]

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Bu çalışma Lamium purpureum L.'yi kimyasal bileşimi ve antikanser aktivitesi için uçucu yağ potansiyeli açısından değerlendirmeyi amaçlamıştır. Kimyasal bileşiminin profil analizi GC-MS ile yapılmıştır. Bu amaçla, etanol ekstresi kimyasal bileşiklerin belirlenmesi için GC-MS analizine tabi tutuldu. Esansiyel yağ elde etmek için, tüm bitkinin (hava, yaprak, gövde) buharla damıtılması bir Clevenger aparatında gerçekleştirildi. Antikanser aktivitesi MTT testi ile belirlendi. 50 μg/mL konsantrasyonunda maksimum hücre ölümünün% 14 olduğunu gözlemledik. GC-MS analizi sonucunda palmitik asit, 7-tetradekenal, oktadecadienoik asit, asetik asit, etil 9,12,15-oktadekatrienoat, heksatriakontan, stearat ve benzil benzoat ana bileşenler olarak tanımlandı. L. purpureum L.'ın uçucu yağının sitotoksik aktivite gösteren temel bileşiklere sahip olduğunu belirledik.

The current study aimed to evaluate Lamium purpureum L. in terms of its chemical composition and the potential of its essential oil for anticancer activity. The profiling analysis of its chemical composition was carried out via GC-MS. For this purpose, the ethanol extract was subjected to GC-MS analysis to determine chemical compounds. To obtain essential oil, steam distillation of the whole plant (aerial, leaf, stem) was carried out in a Clevenger apparatus. The anticancer activitiy was determined via MTT assay. We observed that the maximum cell death was 14% at 50 μg/mL concentration. As a result of GC-MS analysis, palmitic acid, 7-tetradecenal, octadecadienoic acid, acetic acid, ethyl 9,12,15-octadecatrienoate, hexatriacontane, stearate and benzyl benzoate were identified as major components. We determined that the essential oil of L. purpureum L. had essential compounds which showed cytotoxic activities.

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Primary Language en
Subjects Engineering
Journal Section Articles
Authors

Orcid: 0000-0002-3663-7412
Author: Ayşegül Akkoyunlu (Primary Author)
Institution: DUZCE UNIVERSITY
Country: Turkey


Orcid: 0000-0002-1506-1549
Author: Gorkem Dulger
Institution: DUZCE UNIVERSITY
Country: Turkey


Dates

Publication Date: July 31, 2019

Bibtex @research article { dubited553793, journal = {Düzce Üniversitesi Bilim ve Teknoloji Dergisi}, issn = {}, eissn = {2148-2446}, address = {Duzce University}, year = {2019}, volume = {7}, pages = {1755 - 1763}, doi = {10.29130/dubited.553793}, title = {Chemical Composition of Lamium purpureum L. and Determination of Anticancer Activity of Its Essential Oil on Melanoma}, key = {cite}, author = {Akkoyunlu, Ayşegül and Dulger, Gorkem} }
APA Akkoyunlu, A , Dulger, G . (2019). Chemical Composition of Lamium purpureum L. and Determination of Anticancer Activity of Its Essential Oil on Melanoma. Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 7 (3), 1755-1763. DOI: 10.29130/dubited.553793
MLA Akkoyunlu, A , Dulger, G . "Chemical Composition of Lamium purpureum L. and Determination of Anticancer Activity of Its Essential Oil on Melanoma". Düzce Üniversitesi Bilim ve Teknoloji Dergisi 7 (2019): 1755-1763 <http://dergipark.org.tr/dubited/issue/46290/553793>
Chicago Akkoyunlu, A , Dulger, G . "Chemical Composition of Lamium purpureum L. and Determination of Anticancer Activity of Its Essential Oil on Melanoma". Düzce Üniversitesi Bilim ve Teknoloji Dergisi 7 (2019): 1755-1763
RIS TY - JOUR T1 - Chemical Composition of Lamium purpureum L. and Determination of Anticancer Activity of Its Essential Oil on Melanoma AU - Ayşegül Akkoyunlu , Gorkem Dulger Y1 - 2019 PY - 2019 N1 - doi: 10.29130/dubited.553793 DO - 10.29130/dubited.553793 T2 - Düzce Üniversitesi Bilim ve Teknoloji Dergisi JF - Journal JO - JOR SP - 1755 EP - 1763 VL - 7 IS - 3 SN - -2148-2446 M3 - doi: 10.29130/dubited.553793 UR - https://doi.org/10.29130/dubited.553793 Y2 - 2019 ER -
EndNote %0 Duzce University Journal of Science and Technology Chemical Composition of Lamium purpureum L. and Determination of Anticancer Activity of Its Essential Oil on Melanoma %A Ayşegül Akkoyunlu , Gorkem Dulger %T Chemical Composition of Lamium purpureum L. and Determination of Anticancer Activity of Its Essential Oil on Melanoma %D 2019 %J Düzce Üniversitesi Bilim ve Teknoloji Dergisi %P -2148-2446 %V 7 %N 3 %R doi: 10.29130/dubited.553793 %U 10.29130/dubited.553793
ISNAD Akkoyunlu, Ayşegül , Dulger, Gorkem . "Chemical Composition of Lamium purpureum L. and Determination of Anticancer Activity of Its Essential Oil on Melanoma". Düzce Üniversitesi Bilim ve Teknoloji Dergisi 7 / 3 (July 2019): 1755-1763. https://doi.org/10.29130/dubited.553793
AMA Akkoyunlu A , Dulger G . Chemical Composition of Lamium purpureum L. and Determination of Anticancer Activity of Its Essential Oil on Melanoma. DUBİTED. 2019; 7(3): 1755-1763.
Vancouver Akkoyunlu A , Dulger G . Chemical Composition of Lamium purpureum L. and Determination of Anticancer Activity of Its Essential Oil on Melanoma. Düzce Üniversitesi Bilim ve Teknoloji Dergisi. 2019; 7(3): 1763-1755.