Year 2019, Volume 7, Issue 3, Pages 1969 - 1975 2019-07-31

The Possible Effects of Leptin Hormone in Diabetes
Diyabette Leptin Hormonun Olası Etkileri

Eylem Taşkın Güven [1] , Celal Güven [2] , Salih Tunç Kaya [3] , Yusuf Sevgiler [4]

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Diabetes, known as a disorder of glucose, is a metabolic disease that brings about various complications (cardiovascular and circulatory disorder, cancer, and similar diseases) and affects human life negatively. Diabetes is a disease that has two big sub-categories as type I and type II. Beta (β) cell loss by apoptosis in type I diabetics is an important mechanism in the decrease of insulin secretion. Like insulin, leptin is also one of the anti-apoptotic and proliferative hormones. Moreover, it is known that low leptin and insulin treatment are more effective in tamponing blood glucose than only high dose of insulin use. However, this effect/these effects of type I diabetics still keeps its mystery. Another significant effect of leptin in type I diabetes is to tampon blood glucose by increasing in fat oxidation. Moreover, this causes a decrease in insulin resistance. In addition, it is emphasized that leptin not only imitates anabolic effects of insulin but also avoids ketoacidosis that occurs in diabetes. Consequently, leptin treatment enables a decrease in high dose of insulin use. The evidence to be obtained has a potential to help enlighten this complicated relationship between leptin and diabetes in literature by the review.

Şeker hastalığı olarak bilinen diyabet, çeşitli komplikasyonları (kalp ve dolaşım hastalıkları, kanser ve buna benzer hastalıklar) beraberinde getiren, insan hayatını olumsuz yönde etkileyen metabolik bir hastalıktır. Genel olarak diyabet tip I ve tip II olmak üzere iki büyük alt grupta toplanan bir hastalıktır. Tip I diyabette beta (β) hücrelerinin apoptoz ile kaybı insülin salgısının azalmasında önemli bir mekanizmadır. Leptin de insülin gibi antiapoptotik ve proliferatif hormonlardan biridir. Dahası düşük leptin ve insülin tedavisinin sadece yüksek doz insülin kullanımına oranla kan şekerinin tamponlanmasında daha etkili olduğu bildirilmektedir. Fakat leptinin tip I diyabetteki bu etkisi/etkileri hala gizemini korumaktadır. Leptinin tip I diyabetteki önemli etkisinden biri de yağların β oksidasyonunun artmasına neden olarak, kan şekerinin tamponlanmasını da sağları. Bu da insülin direncinin oluşmasının azalmasına neden olmaktadır. Ayrıca leptinin insülinin anabolik etkilerini taklit ettiği gibi diyabette meydana gelen ketoasidozu önlediği de vurgulanmaktadır. Dolayısıyla leptin tedavisi, zorunlu yüksek doz insülin kullanımı azaltılmasına olanak tanıyabilmektedir. Bu derleme, literatürdeki leptin ve diyabet arasındaki

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Primary Language tr
Subjects Engineering
Journal Section Articles
Authors

Orcid: 0000-0001-8172-4980
Author: Eylem Taşkın Güven (Primary Author)
Institution: NİĞDE ÖMER HALİSDEMİR ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, FİZYOLOJİ ANABİLİM DALI
Country: Turkey


Orcid: 0000-0003-0499-7787
Author: Celal Güven
Institution: NİĞDE ÖMER HALİSDEMİR ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, BİYOFİZİK ANABİLİM DALI
Country: Turkey


Orcid: 0000-0002-4133-407X
Author: Salih Tunç Kaya
Institution: DÜZCE ÜNİVERSİTESİ, FEN-EDEBİYAT FAKÜLTESİ, BİYOLOJİ BÖLÜMÜ
Country: Turkey


Orcid: 0000-0002-4373-2389
Author: Yusuf Sevgiler
Institution: ADIYAMAN ÜNİVERSİTESİ, FEN-EDEBİYAT FAKÜLTESİ, BİYOLOJİ BÖLÜMÜ
Country: Turkey


Dates

Publication Date: July 31, 2019

Bibtex @review { dubited578925, journal = {Düzce Üniversitesi Bilim ve Teknoloji Dergisi}, issn = {}, eissn = {2148-2446}, address = {Duzce University}, year = {2019}, volume = {7}, pages = {1969 - 1975}, doi = {10.29130/dubited.578925}, title = {Diyabette Leptin Hormonun Olası Etkileri}, key = {cite}, author = {Taşkın Güven, Eylem and Güven, Celal and Kaya, Salih Tunç and Sevgiler, Yusuf} }
APA Taşkın Güven, E , Güven, C , Kaya, S , Sevgiler, Y . (2019). Diyabette Leptin Hormonun Olası Etkileri. Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 7 (3), 1969-1975. DOI: 10.29130/dubited.578925
MLA Taşkın Güven, E , Güven, C , Kaya, S , Sevgiler, Y . "Diyabette Leptin Hormonun Olası Etkileri". Düzce Üniversitesi Bilim ve Teknoloji Dergisi 7 (2019): 1969-1975 <http://dergipark.org.tr/dubited/issue/46290/578925>
Chicago Taşkın Güven, E , Güven, C , Kaya, S , Sevgiler, Y . "Diyabette Leptin Hormonun Olası Etkileri". Düzce Üniversitesi Bilim ve Teknoloji Dergisi 7 (2019): 1969-1975
RIS TY - JOUR T1 - Diyabette Leptin Hormonun Olası Etkileri AU - Eylem Taşkın Güven , Celal Güven , Salih Tunç Kaya , Yusuf Sevgiler Y1 - 2019 PY - 2019 N1 - doi: 10.29130/dubited.578925 DO - 10.29130/dubited.578925 T2 - Düzce Üniversitesi Bilim ve Teknoloji Dergisi JF - Journal JO - JOR SP - 1969 EP - 1975 VL - 7 IS - 3 SN - -2148-2446 M3 - doi: 10.29130/dubited.578925 UR - https://doi.org/10.29130/dubited.578925 Y2 - 2019 ER -
EndNote %0 Duzce University Journal of Science and Technology Diyabette Leptin Hormonun Olası Etkileri %A Eylem Taşkın Güven , Celal Güven , Salih Tunç Kaya , Yusuf Sevgiler %T Diyabette Leptin Hormonun Olası Etkileri %D 2019 %J Düzce Üniversitesi Bilim ve Teknoloji Dergisi %P -2148-2446 %V 7 %N 3 %R doi: 10.29130/dubited.578925 %U 10.29130/dubited.578925
ISNAD Taşkın Güven, Eylem , Güven, Celal , Kaya, Salih Tunç , Sevgiler, Yusuf . "Diyabette Leptin Hormonun Olası Etkileri". Düzce Üniversitesi Bilim ve Teknoloji Dergisi 7 / 3 (July 2019): 1969-1975. https://doi.org/10.29130/dubited.578925
AMA Taşkın Güven E , Güven C , Kaya S , Sevgiler Y . Diyabette Leptin Hormonun Olası Etkileri. DUBİTED. 2019; 7(3): 1969-1975.
Vancouver Taşkın Güven E , Güven C , Kaya S , Sevgiler Y . Diyabette Leptin Hormonun Olası Etkileri. Düzce Üniversitesi Bilim ve Teknoloji Dergisi. 2019; 7(3): 1975-1969.