Zehirlenmelerde İntravenöz Lipit Emülsiyonu Tedavisi

Yıl 2019, Cilt: 12 Sayı: 1, 70 - 77, 30.06.2019

Emre Bahçivan Halis Oğuz

Öz

İntravenöz lipit emülsiyon (ILE) tedavisi,
dolaşımdaki zehirli maddelerin biyoyararlanım ve toksisitesini azaltmak için
lipit emülsiyonlarının intravenöz infüzyon yoluyla kullanılmasını tanımlar.
Lipit emülsiyonu yağ, emülsifier, tonisite değiştirici madde ve sudan oluşurken
ve bileşiminde yaklaşık %80 su, %20 soya fasulyesi yağı, %2 gliserin ve %1
yumurta sarısı fosfolipidi bulunmaktadır. ILE’nin üretilme amacı öncelikli
olarak yetişkinler, çocuklar ve yeni doğanlar için parenteral beslemedir. Bunun
dışında ILE propofol ve amfoterisin B’de olduğu gibi ilaç taşıyıcısı olarak da
kullanılmaktadır. ILE, lipofilik toksinleri absorbe etme yeteneklerine bağlı
olarak veteriner hekimlikte ve insan hekimliğinde lokal anesteziklerin sistemik
toksisitesinin tedavisinde de antidot olarak kullanılabilmektedir. Lipofilik
ilaçlarla zehirlenmelerin tedavisinde belirgin klinik düzelme, uygulamasının
nispeten kolay olması, düşük maliyet, söz konusu lipit emülsiyonlarının etiket
dışı kullanımının artmasına neden olmuş ve zehirlenmelerin tedavisinde
kullanılabilmesinin yolunu açmıştır. Bu makalede ILE’nin etki mekanizmaları,
endikasyonları, mevcut ticari formülasyonları, dozaj rejimi önerisi ile yan
etkileri hakkında bilgi verilmesi amaçlanmaktadır.

Anahtar Kelimeler

İntravenöz lipid emülsiyonu, lipofilik ilaçlar, zehirlenme

Kaynakça

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