Enzyme Inhibition Studies of Antipyrine and Aminopyrine

Yıl 2019, Cilt: 5 Sayı: 1, 1 - 6, 27.06.2019

Nashia Stellenboom Murat Şentürk

Öz

The
study investigated the enzyme inhibition effects of antipyrine and aminopyrine
against two human carbonic anhydrase isoforms (hCA I and hCA II),
acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The
effectiveness of these compounds as possible carbonic anhydrase (CA) and
cholinesterase (ChE) inhibitors is evident from the nanomolar range IC₅₀
and K_i values obtained. The
results demonstrated that aminopyrine was a more effective inhibitor compared
with antipyrine. Moreover, molecular docking results obtained from the online
docking server SwissDock supported the inhibition activity results.

Anahtar Kelimeler

Aminopyrine, Antipyrine, Acetylcholinesterase, Butyrylcholinesterase, Carbonic Anhydrase

Kaynakça

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