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Primary Splenic angiosarcoma a case report and literature review

Yıl 2019, Cilt: 2 Sayı: 1, 31 - 33, 01.04.2019
https://doi.org/10.33713/egetbd.476284

Öz

Primary
splenic angiosarcoma is a very aggressive neoplasm with poor prognosis due to
its very high frequency of metastasis.
The tumor cells exhibit a strong positivity for at least one of the
endothelial markers (CD31, CD34, and factor VIII).
The diagnosis is usually difficult and late because the patient remains
asymptomatic till the onset of massive intra-abdominal bleeding. Early diagnosis and surgical management is the only
potentially long –term therapeutic option. The current and accepted therapy is
splenectomy.
  Herein, we
report a case of primary splenic angiosarcoma that presented with abdominal
pain, along with a review of the current literature.

Kaynakça

  • Hamid KS, Rodriguez JA, Lairmore TC. Primary splenic angiosarcoma. JSLS. 2010;14(3):431–5.
  • Neuhauser TS, Derringer GA, Thompson LD, Fanburg-Smith JC, Miettinen M, Saaristo A and Abbondanzo SL. Splenic angiosarcoma: a clinicopathologic and immunophenotypic study of 28 cases. Mod Pathol 2000; 13: 978-987.
  • Manouras A, Giannopoulos P, Toufektzian L, Markogiannakis H, Lagoudianakis EE, Papadima A, et al. Splenic rupture as the presenting manifestation of primary splenic angiosarcoma in a teenage woman: a case report. J Med Case Rep. 2008;2:133.
  • Venegas LF, Pohlmann PR, Balbinot AL, Schuck E, de Oliveira CTM, Frank KJ, Dillemburg CF, da Costa MSB, Rivero LFR, Pütten ACK: Angiossarcoma primário de baço: relato de caso e revisão da literatura. Rev Bras Cancerolog 1998;44:12–14.
  • Shukla M, Basu S, Shukla VK, Kumar M. Fever, anaemia, and splenomegaly: A rare presentation of splenic angiosarcoma. Indian J Med Paediatr Oncol. 2011;32:230-32.
  • Falk S, Krishnan J and Meis JM. Primary angiosarcoma of the spleen. A clinicopathologic study of 40 cases. Am J Surg Pathol 1993; 17: 959-970.
  • Alt B, Hafez GR, Trigg M, Shahidi NT and Gilbert EF. Angiosarcoma of the liver and spleen in an infant. Pediatr Pathol 1985; 4: 331-339.
  • Plotnik AN, Schweder P, Tsui A and Kavar B. Splenic angiosarcoma metastasis to the brain. J Clin Neurosci 2008; 15: 927-929.
  • Zwi LJ, Evans DJ, Wechsler AL, Catovsky D. Splenic angiosarcoma following chemotherapy for follicular lymphoma. Hum Pathol 1986; 17: 528-530 [PMID: 3516861 DOI: 10.1016/ S0046-8177(86)80044-2]
  • Z. Kamocki, A. Steward, K. P. Zareba, A. Kukli´nski, and B. Kedra, “Primary splenic angiosarcoma—the same diagnosis yielding two different clinical pictures. Case report,” Contemporary Oncology, vol. 17, no. 2, pp. 218–221, 2013.
  • K. Yoshida, T. Endo, K. Kamata et al., “A case of angiosarcoma of the spleen with intraperitoneal bleeding,” Nihon Shokakibyo Gakkai Zasshi, vol. 111, pp. 549–556, 2014.
  • Autry JR, Weitzner S. Haemangiosarcoma of spleen with spontaneous rupture. Cancer. 1975;35:534-39.
  • Thompson WM, Levy AD, Aguilera NS, Gorospe L, Abbott RM. Angiosarcoma of the spleen: imaging characteristics in 12 patients. Radiology 2005; 235: 106-115 [PMID: 15749977 DOI: 10.1148/ radiol.2351040308]
  • Vrachliotis TG, Bennett WF, Vaswani KK, Niemann TH, Bova JG. Primary angiosarcoma of the spleen--CT, MR, and sonographic characteristics: report of two cases. Abdom Imaging 2000; 25: 283-285 [PMID: 10823452 DOI: 10.1007/s002610000034]
  • Keogan MT, Freed KS, Paulson EK, et al: Imaging-guided percutaneous biopsy of focal splenic lesions: update on safety and effectiveness. AJR Am J Roentgenol 1999;172:933–937.
  • Metser U, Even-Sapir E: The role of 18F-FDG PET/CT in the evaluation of solid splenic masses. Semin Ultrasound CT MR 2006;27:420–425.
  • Delacruz V, Jorda M, Gomez-Fernandez C, Benedetto P and Ganjei P. Fine-needle aspiration diagnosis of angiosarcoma of the spleen: a case report and review of the literature. Arch Pathol Lab Med 2005; 129: 1054-1056.
  • Young RJ, Brown NJ, Reed MW, Hughes D and Woll PJ. Angiosarcoma. Lancet Oncol 2010; 11: 983-991.
  • Hara T, Tsurumi H, Kasahara S, Ogawa K,Takada J, Imai K, et al. Long-term survival of a patient with splenic angiosarcoma after resection, high-dose chemotherapy, and autologous peripheral blood stem cell transplantation. Intern Med. 2010;49:2253-57.
  • P. Montemayor and V. Caggiano, “Primary hemangiosarcoma of the spleen associated with leukocytosis and abnormal spleen scan,” International Surgery, vol. 65, no. 4, pp. 369–373, 1980.
  • Naka N, Ohsawa M, Tomita Y, Kanno H, Uchida A, Myoui A, Aozasa K. Prognostic factors in angiosarcoma: a multivariate analysis of 55 cases. J Surg Oncol 1996; 61: 170-176 [PMID: 8637202]
  • Targarona EM, Espert JJ, Balague C, Piulachs J, Artigas V, Trias M: Splenomegaly should not be considered a contraindication for laparoscopic splenectomy. Ann Surg 1998;228:35–39.
  • Penel N, Bui BN, Bay JO, Cupissol D, Ray-Coquar I, Piperno-Neumann S, et al. Phase II trial of weekly paclitaxel for unresectable angiosarcoma: the ANGIOTAX Study. J Clin Oncol. 2008;26:5269-74.
  • Mehren M, Randall RL, Benjamin RS, et al. NCCN clinical practice guiedlines inoncology (soft tissue sarcoma), 2015

Primer dalak anjisorkom olgu sunumu ve literatür eşliğinde değerlendirme

Yıl 2019, Cilt: 2 Sayı: 1, 31 - 33, 01.04.2019
https://doi.org/10.33713/egetbd.476284

Öz

Primer dalak anjiosarkom nadir görülen ,
sık metastaz yapabilen ,kötü prognozlu, agresif bir neoplazidir. Tümör
hücreleri endotelyal markerlar (CD31, CD34, and faktör VIII) ile güçlü pozitiflik göstermektedir.Erken dönemde
asemptomatik olduğu için hastalar ancak rastlantısal olarak veya karın içi
kanama bulguları gibi nedenlerle geç dönemde tanı alabilmektedir.Erken tanı ve
cerrahi girişim en etkili tedavi yöntemidir.Kabul edilen tedavi yöntemi
splenektomidir.Bu çalışmada kliniğimize karın ağrısı ile başvuran ve primer
dalak anjiosarkom tanısı alan hasta literatür eşliğinde değerlendirilmiştir.

Kaynakça

  • Hamid KS, Rodriguez JA, Lairmore TC. Primary splenic angiosarcoma. JSLS. 2010;14(3):431–5.
  • Neuhauser TS, Derringer GA, Thompson LD, Fanburg-Smith JC, Miettinen M, Saaristo A and Abbondanzo SL. Splenic angiosarcoma: a clinicopathologic and immunophenotypic study of 28 cases. Mod Pathol 2000; 13: 978-987.
  • Manouras A, Giannopoulos P, Toufektzian L, Markogiannakis H, Lagoudianakis EE, Papadima A, et al. Splenic rupture as the presenting manifestation of primary splenic angiosarcoma in a teenage woman: a case report. J Med Case Rep. 2008;2:133.
  • Venegas LF, Pohlmann PR, Balbinot AL, Schuck E, de Oliveira CTM, Frank KJ, Dillemburg CF, da Costa MSB, Rivero LFR, Pütten ACK: Angiossarcoma primário de baço: relato de caso e revisão da literatura. Rev Bras Cancerolog 1998;44:12–14.
  • Shukla M, Basu S, Shukla VK, Kumar M. Fever, anaemia, and splenomegaly: A rare presentation of splenic angiosarcoma. Indian J Med Paediatr Oncol. 2011;32:230-32.
  • Falk S, Krishnan J and Meis JM. Primary angiosarcoma of the spleen. A clinicopathologic study of 40 cases. Am J Surg Pathol 1993; 17: 959-970.
  • Alt B, Hafez GR, Trigg M, Shahidi NT and Gilbert EF. Angiosarcoma of the liver and spleen in an infant. Pediatr Pathol 1985; 4: 331-339.
  • Plotnik AN, Schweder P, Tsui A and Kavar B. Splenic angiosarcoma metastasis to the brain. J Clin Neurosci 2008; 15: 927-929.
  • Zwi LJ, Evans DJ, Wechsler AL, Catovsky D. Splenic angiosarcoma following chemotherapy for follicular lymphoma. Hum Pathol 1986; 17: 528-530 [PMID: 3516861 DOI: 10.1016/ S0046-8177(86)80044-2]
  • Z. Kamocki, A. Steward, K. P. Zareba, A. Kukli´nski, and B. Kedra, “Primary splenic angiosarcoma—the same diagnosis yielding two different clinical pictures. Case report,” Contemporary Oncology, vol. 17, no. 2, pp. 218–221, 2013.
  • K. Yoshida, T. Endo, K. Kamata et al., “A case of angiosarcoma of the spleen with intraperitoneal bleeding,” Nihon Shokakibyo Gakkai Zasshi, vol. 111, pp. 549–556, 2014.
  • Autry JR, Weitzner S. Haemangiosarcoma of spleen with spontaneous rupture. Cancer. 1975;35:534-39.
  • Thompson WM, Levy AD, Aguilera NS, Gorospe L, Abbott RM. Angiosarcoma of the spleen: imaging characteristics in 12 patients. Radiology 2005; 235: 106-115 [PMID: 15749977 DOI: 10.1148/ radiol.2351040308]
  • Vrachliotis TG, Bennett WF, Vaswani KK, Niemann TH, Bova JG. Primary angiosarcoma of the spleen--CT, MR, and sonographic characteristics: report of two cases. Abdom Imaging 2000; 25: 283-285 [PMID: 10823452 DOI: 10.1007/s002610000034]
  • Keogan MT, Freed KS, Paulson EK, et al: Imaging-guided percutaneous biopsy of focal splenic lesions: update on safety and effectiveness. AJR Am J Roentgenol 1999;172:933–937.
  • Metser U, Even-Sapir E: The role of 18F-FDG PET/CT in the evaluation of solid splenic masses. Semin Ultrasound CT MR 2006;27:420–425.
  • Delacruz V, Jorda M, Gomez-Fernandez C, Benedetto P and Ganjei P. Fine-needle aspiration diagnosis of angiosarcoma of the spleen: a case report and review of the literature. Arch Pathol Lab Med 2005; 129: 1054-1056.
  • Young RJ, Brown NJ, Reed MW, Hughes D and Woll PJ. Angiosarcoma. Lancet Oncol 2010; 11: 983-991.
  • Hara T, Tsurumi H, Kasahara S, Ogawa K,Takada J, Imai K, et al. Long-term survival of a patient with splenic angiosarcoma after resection, high-dose chemotherapy, and autologous peripheral blood stem cell transplantation. Intern Med. 2010;49:2253-57.
  • P. Montemayor and V. Caggiano, “Primary hemangiosarcoma of the spleen associated with leukocytosis and abnormal spleen scan,” International Surgery, vol. 65, no. 4, pp. 369–373, 1980.
  • Naka N, Ohsawa M, Tomita Y, Kanno H, Uchida A, Myoui A, Aozasa K. Prognostic factors in angiosarcoma: a multivariate analysis of 55 cases. J Surg Oncol 1996; 61: 170-176 [PMID: 8637202]
  • Targarona EM, Espert JJ, Balague C, Piulachs J, Artigas V, Trias M: Splenomegaly should not be considered a contraindication for laparoscopic splenectomy. Ann Surg 1998;228:35–39.
  • Penel N, Bui BN, Bay JO, Cupissol D, Ray-Coquar I, Piperno-Neumann S, et al. Phase II trial of weekly paclitaxel for unresectable angiosarcoma: the ANGIOTAX Study. J Clin Oncol. 2008;26:5269-74.
  • Mehren M, Randall RL, Benjamin RS, et al. NCCN clinical practice guiedlines inoncology (soft tissue sarcoma), 2015
Toplam 24 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Cerrahi
Bölüm Olgu Sunumu
Yazarlar

Murat Güner

Nurullah Damburacı

Mehmet Gündoğan Bu kişi benim

Utku Dönem Dilli Bu kişi benim

Coşkun Ege Oğuzer Bu kişi benim

Barış Sevinç

Yayımlanma Tarihi 1 Nisan 2019
Kabul Tarihi 27 Ocak 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 2 Sayı: 1

Kaynak Göster

EndNote Güner M, Damburacı N, Gündoğan M, Dilli UD, Oğuzer CE, Sevinç B (01 Nisan 2019) Primary Splenic angiosarcoma a case report and literature review. Ege Tıp Bilimleri Dergisi 2 1 31–33.

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