Year 2018, Volume 2, Issue 2, Pages 85 - 92 2018-12-29

The Ketogenic Diet and its Clinical Applications in Type I and II Diabetes

Raffaele Pilla [1]

13 128

Nutritional ketosis is effective to contrast seizure disorders and other acute and chronic neurological disorders. Glucose is the primary metabolic fuel for cells, however many neurodegenerative disorders have been recently associated with impaired glucose transport and metabolism causing energy deficits, such as in Alzheimer’s disease, Parkinson’s disease, general seizure disorders, and traumatic brain injury. Ketone bodies and tricarboxylic acid cycle intermediates can bypass the rate-limiting steps associated with impaired neuronal glucose metabolism. After prolonged periods of fasting or ketogenic diet (KD), the body utilizes energy obtained from free fatty acids (FFAs) released from adipose tissue. Hepatic ketogenesis converts FFAs into ketone bodies-hydroxybutyrate and acetoacetate, while a percentage of acetoacetate spontaneously decarboxylates to acetone. This represents a state of normal physiological ketosis and can be therapeutic. Therapeutic ketosis leads to metabolic adaptations that may improve brain metabolism, restore mitochondrial ATP production, decrease reactive oxygen species production, reduce inflammation, and increase neurotrophic factors’ function. It has been shown that KD mimics the effects of fasting and the lack of glucose/insulin signaling, which promotes a metabolic shift towards fatty acid utilization. KD can only induce a modest blood ketone level elevation and requires extreme dietary carbohydrate restriction for maintaining sustained levels of ketosis. Prior to the advent of exogenous insulin for the treatment of diabetes mellitus in the 1920's, general guidelines for therapy were represented only by dietary modifications. For example, Dr. Elliot Joslin’s Diabetic Diet in 1923 consisted of "meats, poultry, game, fish, clear soups, gelatin, eggs, butter, olive oil, coffee, tea" and contained approximately 5% of energy from carbohydrates, 20% from protein, and 75% from fat. A similar diet was advocated by Dr. Frederick Allen. The aim of this work is to analyze the current literature on therapeutic ketosis and its successful clinical applications in diabetes type I and II.

Ketogenic Diet, Nutrition, ketosis, therapeutic ketosis, ketogenesis, diabetes type I, diabetes type II, cure
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Primary Language en
Subjects Food Science and Technology
Journal Section Article

Author: Raffaele Pilla (Primary Author)
Country: Italy

Bibtex @review { ejfst507033, journal = {Eurasian Journal of Food Science and Technology}, issn = {}, address = {Rüveyda Mervenur BAĞDATLI}, year = {2018}, volume = {2}, pages = {85 - 92}, doi = {}, title = {The Ketogenic Diet and its Clinical Applications in Type I and II Diabetes}, key = {cite}, author = {Pilla, Raffaele} }
APA Pilla, R . (2018). The Ketogenic Diet and its Clinical Applications in Type I and II Diabetes. Eurasian Journal of Food Science and Technology, 2 (2), 85-92. Retrieved from
MLA Pilla, R . "The Ketogenic Diet and its Clinical Applications in Type I and II Diabetes". Eurasian Journal of Food Science and Technology 2 (2018): 85-92 <>
Chicago Pilla, R . "The Ketogenic Diet and its Clinical Applications in Type I and II Diabetes". Eurasian Journal of Food Science and Technology 2 (2018): 85-92
RIS TY - JOUR T1 - The Ketogenic Diet and its Clinical Applications in Type I and II Diabetes AU - Raffaele Pilla Y1 - 2018 PY - 2018 N1 - DO - T2 - Eurasian Journal of Food Science and Technology JF - Journal JO - JOR SP - 85 EP - 92 VL - 2 IS - 2 SN - - M3 - UR - Y2 - 2019 ER -
EndNote %0 Eurasian Journal of Food Science and Technology The Ketogenic Diet and its Clinical Applications in Type I and II Diabetes %A Raffaele Pilla %T The Ketogenic Diet and its Clinical Applications in Type I and II Diabetes %D 2018 %J Eurasian Journal of Food Science and Technology %P - %V 2 %N 2 %R %U
ISNAD Pilla, Raffaele . "The Ketogenic Diet and its Clinical Applications in Type I and II Diabetes". Eurasian Journal of Food Science and Technology 2 / 2 (December 2018): 85-92.