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The relationship between AB0 blood groups and COVID-19

Year 2020, Volume: 4 Issue: 11, 956 - 959, 01.11.2020

Ali Gür , Muhammed Ekmekyapar , Levent Şahin

https://doi.org/10.28982/josam.799750

Abstract

Aim: Although COVID-19 infection spreads very quickly, not every individual is infected at the same rate. It should be investigated whether blood groups affect this difference in susceptibility to COVID-19. This study was conducted to investigate whether there was a relationship between AB0 and Rh blood groups and COVID-19 patients.
Methods: A total of 535 patients suspected of COVID-19 who were admitted to the emergency departments and pandemic polyclinics of 3 different hospitals were included in this prospective cohort study. The patients were divided into two groups as those with positive and negative results according to the swab test. According to the ABO and Rh subgroups of the patients whose blood groups were known, each patient was evaluated for the presence of COVID-19. The data on patients' age, gender, complaints during the admission, blood groups, and swab test results were recorded in the study forms, and statistical analyses were performed.
Results: The mean age of the patients was 45.5 (22.2) years. There were 291 (54.40%) males and 244 (45.60%) females. It was observed that most patients had A Rh + blood group (n=225, 42.1%). When age groups were compared in terms of gender, swab test results, and blood groups, no significant differences were found (P=0.307, P=0.316 and P=0.694, respectively).
Conclusion: We found that no specific blood group increased the risk of getting infected with COVID-19. However, according to our results, those with A Rh – and A Rh +, 0 Rh - and AB Rh - blood groups had a higher risk of catching COVID-19, while those with 0 Rh + blood group had a lower risk.

Keywords

Blood Group COVID-19 Pandemic Infeciton

References

  • 1. Zhu J, Zhong Z, Ji P, Li H, Li B, Pang J, et al. Clinicopathological characteristics of 8697 patients with COVID-19 in China: a meta-analysis. Fam Med Com Health. 2020;8:e000406. doi: 10.1136/fmch-2020-000406.
  • 2. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020 Feb 15;395(10223):507-13. doi: 10.1016/S0140-6736(20)30211-7.
  • 3. Batool Z, Durrani SH, Tariq S. Association Of Abo And Rh Blood Group Types To Hepatitis B, Hepatitis C, Hiv And Syphilis Infection, A Five Year' Experience In Healthy Blood Donors In A Tertiary Care Hospital. J Ayub Med Coll Abbottabad. 2017 Jan-Mar;29(1):90-2.
  • 4. Lindesmith L, Moe C, Marionneau S, Ruvoen N, Jiang X, Lindblad L, et al. Human susceptibility and resistance to Norwalk virus infection. J Nat Med. 2003 May;9(5):548-53..
  • 5. Jing W, Zhao S, Liu J, Liu M. ABO blood groups and hepatitis B virus infection: a systematic review and meta-analysis. BMJ Open. 2020;10(1):e034114. doi: 10.1136/bmjopen-2019-034114.
  • 6. Gu J, Korteweg C. Pathology and pathogenesis of severe acute respiratory syndrome. Am J Pathol. 2007;170:1136–47.
  • 7. Cheng Y, Cheng G, Chui CH, Lau FY, Chan PK, Margaret HL, et al. ABO blood group and susceptibility to severe acute respiratory syndrome. JAMA. 2005;293(12):1450-1. doi: 10.1001/jama.293.12.1450-c
  • 8. Cooling L. Blood groups in infection and host susceptibility. Clinical Microbiology Reviews. 2015;28(3):801-70. doi: 10.1128/CMR.00109-14
  • 9. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al A novel coronavirus from patients with pneumonia in China, 2019. New Engl J Med. 2020;382:727–33.
  • 10. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet. 2020;395:1054–62.
  • 11. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061.
  • 12. Fang L, Karakiulakis G, Roth M. Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Lancet Respirat Med. 2020;8:e21.
  • 13. Chen J, Subbarao K. The immunobiology of SARS. Ann Rev Immunol. 2007;25:443–72.
  • 14. Juyi L, Xiufang W, Jian C, Yi C, Aiping D, Ming Y. Association between ABO blood groups and risk of SARS-CoV2 pneumonia. Br J Haematol. 2020 Jul;190(1):24-7. doi: 10.1111/bjh.16797
  • 15. Zhao J, Yang Y, Huang H, Li D, Gu D, Lu X, et al. Relationship between the ABO Blood Group and the COVID-19 Susceptibility. medRxiv preprint. 11 March, 2020. doi: 10.1101/2020.03.11.20031096.
  • 16. Göker H, Karakulak EA, Demiroğlu H, Ayaz MC, Büyükaşık Y, İnkaya AC, et al. The effects of blood group types on the risk of COVID-19 infection and its clinical outcome. Turkish Journal of Medical Sciences. 2020;50:679-83. doi: 10.3906/sag-2005-395.
  • 17. Wua Y, Fengb Z, Lia P, Yua Q. Relationship between ABO blood group distribution and clinical characteristics in patients with COVID-19. Clinica Chimica Acta. 2020;509:220–3.
  • 18. https://www.kanver.org/EKutuphane/GruplamaLaboratuari, erişim; 16 Mart 2020

AB0 kan grupları ile COVID-19 arasındaki ilişki

Year 2020, Volume: 4 Issue: 11, 956 - 959, 01.11.2020

Ali Gür , Muhammed Ekmekyapar , Levent Şahin

https://doi.org/10.28982/josam.799750

Abstract

Amaç: COVID-19 enfeksiyonu toplumda çok hızlı yayılmasına rağmen her birey aynı hızla enfeksiyona yakalanmamaktadır. Bireylerin COVID-19’a yakalanmasındaki bu farklılıkların temelinde genetik olarak kan grupların bir etkisinin olup olmadığı araştırılmalıdır. Bu çalışma ABO ve Rh kan grupları ile COVID-19 hastaları arasında bir ilişki olup olmadığını araştırmak amaçlı yapılmıştır.
Yöntemler: 3 farklı hastanenin acil servis ve pandemi polikliniklerine başvuran toplam 535 Covid-19 şüpheli hasta bu prospektif kohort çalışmasına dahil edildi. Hastalar, alınan sürüntü testine göre pozitif ve negatif sonuç olmak üzere iki gruba ayrıldı. Kan grupları belli olan hastalardan ABO ve Rh alt gruplarına göre her hasta Covid-19 varlığı açısından değerlendirildi. Hastaların yaş, cinsiyet, başvuru anındaki şikayetleri, kan grupları ve sürüntü test sonuçları verileri çalışma formlarına kayıt edilip istatistiksel analizleri yapıldı.
Bulgular: Hastaların yaş ortalaması (standart sapması) 45,5 (22,2) yıl idi. Toplam 291 (%54,40) erkek ve 244 (%45,60) kadın hasta vardı. Kan gruplarına bakıldığında en fazla 225 (%42,1) ile A Rh + kan grubuna sahip hastalar olduğu görüldü. Yaş gruplarıyla; cinsiyet ile ve sürüntü test sonuçları ile kan grupları arasında karşılaştırıldığında anlamlı bir farklılık bulunmadı (sırasıyla P=0,307, P=0,316, P=0,694).
Sonuç: Spesifik bir kan grubunda COVID-19’a yakalanma riskinde artış olmadığı görüldü. Ancak A Rh – ve A Rh +, 0 Rh - ve AB Rh - kan gruplarının COVID-19’a yakalanma riskinin yüksek olduğunu, 0 Rh + kan grubunda ise hastalığa yakalanma riskinin daha düşük olduğunu tespit ettik.

Keywords

Kan grubu Covid-19 Pandemi Enfeksiyon

References

  • 1. Zhu J, Zhong Z, Ji P, Li H, Li B, Pang J, et al. Clinicopathological characteristics of 8697 patients with COVID-19 in China: a meta-analysis. Fam Med Com Health. 2020;8:e000406. doi: 10.1136/fmch-2020-000406.
  • 2. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020 Feb 15;395(10223):507-13. doi: 10.1016/S0140-6736(20)30211-7.
  • 3. Batool Z, Durrani SH, Tariq S. Association Of Abo And Rh Blood Group Types To Hepatitis B, Hepatitis C, Hiv And Syphilis Infection, A Five Year' Experience In Healthy Blood Donors In A Tertiary Care Hospital. J Ayub Med Coll Abbottabad. 2017 Jan-Mar;29(1):90-2.
  • 4. Lindesmith L, Moe C, Marionneau S, Ruvoen N, Jiang X, Lindblad L, et al. Human susceptibility and resistance to Norwalk virus infection. J Nat Med. 2003 May;9(5):548-53..
  • 5. Jing W, Zhao S, Liu J, Liu M. ABO blood groups and hepatitis B virus infection: a systematic review and meta-analysis. BMJ Open. 2020;10(1):e034114. doi: 10.1136/bmjopen-2019-034114.
  • 6. Gu J, Korteweg C. Pathology and pathogenesis of severe acute respiratory syndrome. Am J Pathol. 2007;170:1136–47.
  • 7. Cheng Y, Cheng G, Chui CH, Lau FY, Chan PK, Margaret HL, et al. ABO blood group and susceptibility to severe acute respiratory syndrome. JAMA. 2005;293(12):1450-1. doi: 10.1001/jama.293.12.1450-c
  • 8. Cooling L. Blood groups in infection and host susceptibility. Clinical Microbiology Reviews. 2015;28(3):801-70. doi: 10.1128/CMR.00109-14
  • 9. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al A novel coronavirus from patients with pneumonia in China, 2019. New Engl J Med. 2020;382:727–33.
  • 10. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet. 2020;395:1054–62.
  • 11. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061.
  • 12. Fang L, Karakiulakis G, Roth M. Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Lancet Respirat Med. 2020;8:e21.
  • 13. Chen J, Subbarao K. The immunobiology of SARS. Ann Rev Immunol. 2007;25:443–72.
  • 14. Juyi L, Xiufang W, Jian C, Yi C, Aiping D, Ming Y. Association between ABO blood groups and risk of SARS-CoV2 pneumonia. Br J Haematol. 2020 Jul;190(1):24-7. doi: 10.1111/bjh.16797
  • 15. Zhao J, Yang Y, Huang H, Li D, Gu D, Lu X, et al. Relationship between the ABO Blood Group and the COVID-19 Susceptibility. medRxiv preprint. 11 March, 2020. doi: 10.1101/2020.03.11.20031096.
  • 16. Göker H, Karakulak EA, Demiroğlu H, Ayaz MC, Büyükaşık Y, İnkaya AC, et al. The effects of blood group types on the risk of COVID-19 infection and its clinical outcome. Turkish Journal of Medical Sciences. 2020;50:679-83. doi: 10.3906/sag-2005-395.
  • 17. Wua Y, Fengb Z, Lia P, Yua Q. Relationship between ABO blood group distribution and clinical characteristics in patients with COVID-19. Clinica Chimica Acta. 2020;509:220–3.
  • 18. https://www.kanver.org/EKutuphane/GruplamaLaboratuari, erişim; 16 Mart 2020
There are 18 citations in total.

Details

Primary Language English
Subjects Emergency Medicine
Journal Section Research article
Authors

Ali Gür 0000-0002-7823-0266

Muhammed Ekmekyapar 0000-0001-7008-2695

Levent Şahin 0000-0003-0193-4393

Publication Date November 1, 2020
Published in Issue Year 2020 Volume: 4 Issue: 11

Cite

APA Gür, A., Ekmekyapar, M., & Şahin, L. (2020). The relationship between AB0 blood groups and COVID-19. Journal of Surgery and Medicine, 4(11), 956-959. https://doi.org/10.28982/josam.799750
AMA Gür A, Ekmekyapar M, Şahin L. The relationship between AB0 blood groups and COVID-19. J Surg Med. November 2020;4(11):956-959. doi:10.28982/josam.799750
Chicago Gür, Ali, Muhammed Ekmekyapar, and Levent Şahin. “The Relationship Between AB0 Blood Groups and COVID-19”. Journal of Surgery and Medicine 4, no. 11 (November 2020): 956-59. https://doi.org/10.28982/josam.799750.
EndNote Gür A, Ekmekyapar M, Şahin L (November 1, 2020) The relationship between AB0 blood groups and COVID-19. Journal of Surgery and Medicine 4 11 956–959.
IEEE A. Gür, M. Ekmekyapar, and L. Şahin, “The relationship between AB0 blood groups and COVID-19”, J Surg Med, vol. 4, no. 11, pp. 956–959, 2020, doi: 10.28982/josam.799750.
ISNAD Gür, Ali et al. “The Relationship Between AB0 Blood Groups and COVID-19”. Journal of Surgery and Medicine 4/11 (November 2020), 956-959. https://doi.org/10.28982/josam.799750.
JAMA Gür A, Ekmekyapar M, Şahin L. The relationship between AB0 blood groups and COVID-19. J Surg Med. 2020;4:956–959.
MLA Gür, Ali et al. “The Relationship Between AB0 Blood Groups and COVID-19”. Journal of Surgery and Medicine, vol. 4, no. 11, 2020, pp. 956-9, doi:10.28982/josam.799750.
Vancouver Gür A, Ekmekyapar M, Şahin L. The relationship between AB0 blood groups and COVID-19. J Surg Med. 2020;4(11):956-9.
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