TY - JOUR T1 - Pharmacological activities of extracts and isolated compounds of Acalypha Fruticosa Forssk. (Euphorbiaceae) TT - Pharmacological activities of extracts and isolated compounds of Acalypha Fruticosa Forssk. (Euphorbiaceae) AU - Vivekanandarajah Sathasivampillai, Saravanan AU - Shanmugalingam, Vinujan AU - Sebastian, Pholtan Rajeev PY - 2022 DA - September JF - International Journal of Secondary Metabolite JO - Int. J. Sec. Metabolite PB - İzzet KARA WT - DergiPark SN - 2148-6905 SP - 290 EP - 304 VL - 9 IS - 3 LA - en AB - Acalypha fruticosa Forssk is a shrub belonging to the family Euphorbiaceae. A. fruticosa has a wide adaptation through traditional medicinal uses to cure several disorders such as dermatitis, diarrhea, dyspepsia, eye infection, inflammations, and stomachache. This article objects to identify, analyze, and document the reported pharmacological activities of A. fruticosa. Electronic databases namely, PubMed, ScienceDirect, Scopus, and Web of Science were employed to identify the related publications from 1900 to August 2021. Compounds such as 1, 2-benzene dicarboxylic acid diisooctyl ester, and eicosyltrichlorosilane were recognized from different parts of this plant species. Until now, only in vivo and in vitro scientific evidence is available for several pharmacological activities for A. fruticosa. Various parts of this plant species have anticancer, antidiabetic, anthelmintic, antibacterial, antileishmanial, and antiplasmodial properties. This work will benefit the investigators on pharmacological and phytochemical investigations of this plant species in the future. KW - Acalypha fruticosa KW - Anticancer KW - Bioactivity KW - Euphorbiaceae KW - Traditional Medicine N2 - Acalypha fruticosa Forssk is a shrub belonging to the family Euphorbiaceae. A. fruticosa has a wide adaptation through traditional medicinal uses to cure several disorders such as dermatitis, diarrhea, dyspepsia, eye infection, inflammations, and stomachache. This article objects to identify, analyze, and document the reported pharmacological activities of A. fruticosa. Electronic databases namely, PubMed, ScienceDirect, Scopus, and Web of Science were employed to identify the related publications from 1900 to August 2021. Compounds such as 1, 2-benzene dicarboxylic acid diisooctyl ester, and eicosyltrichlorosilane were recognized from different parts of this plant species. Until now, only in vivo and in vitro scientific evidence is available for several pharmacological activities for A. fruticosa. Various parts of this plant species have anticancer, antidiabetic, anthelmintic, antibacterial, antileishmanial, and antiplasmodial properties. This work will benefit the investigators on pharmacological and phytochemical investigations of this plant species in the future. CR - Alasbahi, R.H., Safiyeva, S., & Craker, L.E. (1999). Antimicrobial activity of some Yemeni medicinal plants. J. Herbs Spices Med. Plants., 6, 75 83. https://doi.org/10.1300/J044v06n03_07 CR - Al-Massarani, S., El-Sayed, M.I.K., & El-Shaibany, A. (2019). Antioxidant and anti-proliferative activities of Acalypha fruticosa: Possible elucidated mechanism. Pak. J. Pharm. Sci., 32, 2041–2050. CR - Alshawsh, M.A., Mothana, R.A., Al-shamahy, H.A., Alsllami, S.F., & Lindequist, U. (2007). Assessment of Antimalarial Activity against Plasmodium falciparum and Phytochemical Screening of Some Yemeni Medicinal Plants. Evid. Based Complement. Alternat. Med., 6, 453–456. https://doi.org/10.1093/ecam/nem148 CR - Ambasta, S.P. (1986). The Useful Plants of India. Publication and Information Directorate, CSIR, New Delhi, India, pp. 8. CR - Anonymous. (1988). The Wealth of India- Raw Materials, Vol-1, CSIR, New Delhi, India, pp. 47- 48. CR - Chellappandian, M., Saravanan, M., Pandikumar, P., Harikrishnan, P., Thirugnanasambantham, K., Subramanian, S., Hairul - Islam, V.I., & Ignacimuthu, S. (2018). Traditionally practiced medicinal plant extracts inhibit the ergosterol biosynthesis of clinically isolated dermatophytic pathogens. J. Mycol. Med., 28, 143–149. https://doi.org/10.1016/j.mycmed.2017.11.001 CR - Deepaa, C.V., Chalchat, J.C., & John, J.A. (2012). Chemical composition of the essential oil from the leaves of Acalypha fruticosa. J. Essent. Oil-Bear. Plants, 15, 609–613. https://doi.org/10.1080/0972060X.2012.10644095 CR - Duraipandiyan, V., Ayyanar, M., & Ignacimuthu, S. (2006). Antimicrobial activity of some ethnomedicinal plants used by Paliyar tribe from Tamil Nadu, India. BMC Complement. Altern. Med., 6, 35. https://doi.org/10.1186/1472-6882-6-35 CR - Duraipandiyan, V., & Ignacimuthu, S. (2011). Antifungal activity of traditional medicinal plants from Tamil Nadu, India. Asian Pac. J. Trop. Biomed., 1(SUPPL. 2), S204–S215. https://doi.org/10.1016/S2221-1691(11)60157-3 CR - El-Shaibany, A., Al-Habori, M., Al-Massarani, S., Al-Adhl, A., & Michalsen, A. (2015). Hypoglycemic activity of Acalypha fruticosa forssk extracts in normal rabbits. Trop. J. Pharm. Res., 14, 1445–1450. https://doi.org/10.4314/tjpr.v14i8.17 CR - Fawzy, G.A., Al-Taweel, A.M., Perveen, S., Shabana, I.K., & Fatma, A.A. (2016). Bioactivity and chemical characterization of Acalypha fruticosa Forssk. growing in Saudi Arabia. Saudi Pharm. J., 25, 104–109. https://doi.org/10.1016/j.jsps.2016.05.004 CR - Fleurentin, J., & Pelt, J.M. (1982). Repertory of drugs and medicinal plants of Yemen. J. Ethnopharmacol., 6, 85-108. CR - Gopalakrishnan, S., Saroja, K., & Elizabeth, J.D. (2010). Chemical investigations of aerial parts of Acalypha fruticosa forssk. Der. Pharma. Chem., 2, 383–389. CR - Govindu, S., & Adikay, S. (2014). Evaluation of antiepileptic activity of chloroform extract of Acalypha fruticosa in mice. Pharmacogn. Res., 6, 108–112. https://doi.org/10.4103/0974-8490.128970 CR - Kew Science; Plants of the world online, Acalypha fruticosa, (2021). http://www.plantsoftheworldonline.org/taxon/urn:lsid:ipni.org:names:664873-1 CR - Khare, C. (2007). Acalypha fruticosa Forsk. In: Khare C. (eds) Indian Medicinal Plants. Springer. https://doi.org/10.1007/978-0-387-70638-2_19 CR - Kirtikar, K.R., & Basu, B.D. (2003). Indian Medicinal Plants, Vol. 3, Bishen Singh Mahendra Pal Sing, Dehra Dun, India, pp. 2261. CR - Mothana, R., Al-Musayeib, N., Al-Ajmi, M.F., Cos, P., & Maes, L. (2014). Evaluation of the in vitro antiplasmodial, antileishmanial, and antitrypanosomal activities of selected medicinal plants from the Arabian Peninsula. Planta Medica., 79, PA24. https://doi.org/10.1055/s-0033-1351928 CR - Mothana, R.A.A., Abdo, S.A.A., Hasson, S., Althawab, F.M.N., Alaghbari, S.A.Z., & Lindequist, U. (2010). Antimicrobial, antioxidant, and cytotoxic activities and phytochemical screening of some Yemeni medicinal plants. Evid. Based Complement. Alternat. Med., 7, 323–330. https://doi.org/10.1093/ecam/nen004 CR - Mothana, R.A.A., Grünert, R., Lindequist, U., & Bednarski, P.J. (2006). Study of the anticancer potential of Yemeni plants used in folk medicine. Pharmazie, 62, 305–307. https://doi.org/10.1691/ph.2007.4.6696 CR - Muthukumarasamy, S., Mohan, V.R., Kumaresan, S., & Chelladurai, V.K. (2003). Herbal remedies of paliyar tribe of grizzled giant squirrel wildlife sanctuary, Western Ghats, Srivilliputhur, Tamil Nadu for poisonous bites. J. Econ. Taxon. Bot., 27, 761‑764. CR - Raj, L., Gadamsetty, G., & Sarada, N.C. (2012). Comparative studies on in vitro anthelmintic activity of Gymnema sylvestre and Acalypha fruticosa forssk. Int. J. Pharm., 4, 107–109. CR - Rajkumar, V., Guha, G., & Ashok Kumar, R. (2010) Therapeutic potential of Acalypha fruticosa. Food Chem. Toxicol., 48, 1709–1713. https://doi.org/10.1016/j.fct.2010.03.050 CR - Ruffo, C.K., Birnie, A., & Tengnas, B. (2002). Edible wild plants of Tanzania. RELMA Technical Handbook Series 27. Nairobi, Kenya: Regional Land Management Unit (RELMA), Swedish International Development Cooperation Agency (Sida), pp. 80. CR - Schmelzer, G.H. (2007). Acalypha fruticosa Forssk. In: Medicinal plants. Netherlands: PROTA, pp. 11. CR - Senthilkumar, M., Gurumoorthi, P., & Janardhanan, K. (2006). Some medicinal plants used by Irular, the tribal people of Marudhamalai hills, Coimbatore, Tamil Nadu. Nat. Prod. Radiance, 5, 382–388. CR - Sivakumar, T., Murthi, M.N.V., & Kumutha, P. (2010). Evaluation of anti-tumor and anti-oxidant activity of Acalypha fruticosa in Ehrlich’s Ascites Carcinoma bearing Swiss albino mice. Res. J. Pharm. Biol. Chem., 1, 191–199. CR - Thambiraj, J., & Paulsamy, S. (2011). Antimicrobial screening of stem extract of the folklore medicinal plant, Acalypha fruticosa forssk. Int. J. Pharm., 3, 285–287. CR - Thambiraj, J., Paulsamy, S., & Sevukaperumal, R. (2012). Evaluation of in vitro antioxidant activity in the traditional medicinal shrub of western districts of Tamil Nadu, India, Acalypha fruticosa Forssk. (Euphorbiaceae). Asian Pac. J. Trop. Biomed., 2, S127–S130. https://doi.org/10.1016/S2221-1691(12)60142-7 UR - https://dergipark.org.tr/en/pub/ijsm/issue//1006238 L1 - https://dergipark.org.tr/en/download/article-file/2015716 ER -