@article{article_1012215, title={QUANTITATIVE ASSESSMENT OF RENAL STEATOSIS AND ITS RELATIONSHIP WITH CLINICAL STAGE IN CHRONIC RENAL FAILURE USING CHEMICAL SHIFT MRI}, journal={The Journal of Kırıkkale University Faculty of Medicine}, volume={24}, pages={93–101}, year={2022}, author={Aydın, Hüseyin and Şalkacı, Abdulkerim and Karaibrahimoğlu, Adnan and Dilli, Alper}, keywords={Magnetic resonance imaging, chronic renal disease, diabetes mellitus}, abstract={<div style="text-align:justify;"> <b>Objective: </b>Quantitative measurement of renal parenchymal lipid accumulation in chronic renal disease using chemical shift magnetic resonance imaging and evaluation of its relationship with clinical stages. </div> <div style="text-align:justify;"> <b>Material and Methods: </b>In this retrospective study, the groups were designed as in chronic renal disease (n=46), diabetes without chronic renal disease (n=31), and control (n=59). Chronic renal disease group also divided into two subgroups as diabetic chronic renal disease (n=25) and non-diabetic chronic renal disease (n=21). A total of 272 kidneys of 136 patients were evaluated. Chronic renal disease clinical staging was performed according to e-GFR values. All magnetic resonance imaging examinations were performed with a 1.5 Tesla device. Chemical shift imaging was used in this study to quantify fat in the renal parenchyma (in-phase, out-of-phase, Dixon-water and Dixon-fat). Measurements were made from kidney and spleen by two different methods as whole parenchyma (first method) and focal parenchymal (second method). The fat fraction, and spleen-to-renal chemical shift imaging ratio were calculated. </div> <div style="text-align:justify;"> <b>Results: </b>In the control group, parenchymal fat fraction according to first and second measurement methods were calculated as 0.05±0.01 and 0.05 ± 0.02, respectively. In the chronic renal disease groups, fat fraction measurements were 0.07±0.02 and 0.07±0.04, respectively, and they were found to be significantly higher from chronic renal disease stage 3 compared to the control group (p<0.001). No significant difference was observed in fat fraction and spleen-to-renal chemical shift imaging ratio values in diabetes patients (p>0.05). </div> <div style="text-align:justify;"> <b>Conclusion: </b>In chronic renal disease, starting from stage 3, there is a significant renal parenchymal lipid accumulation compared to the control group and diabetic patients. </div>}, number={1}, publisher={Kirikkale University}, organization={YOK}