@article{article_1032919, title={Determination of Half Maximal Effective Concentration (EC50) Values on Skeletal Muscle Mechanic Activityof Arum dioscoridis, a Species Belonging to Arum Genus, One of the Plants of Karaman Province Region (Phase 0 – Preclinical Studies).}, journal={Karamanoğlu Mehmetbey Üniversitesi Mühendislik ve Doğa Bilimleri Dergisi}, volume={3}, pages={86–109}, year={2021}, author={Özbay, Erkan and Türkseven, Çağatay Han and Karagöz, Sami and Büyükakıllı, Belgin}, keywords={Arum dioscoridis, muscle mechanical activity, EC50, MnTC}, abstract={Arum dioscoridis (AD) is one of the plants that is used phytotherapeutically not only in Anatolia but also in various parts of the world. There is no study in the literature on the effects of this planton on muscle mechanic activity. In this pilot study, half maximal effective concentration values (EC50) of AD on contractile activity of skeletal muscle were determined. The mechanical responses of the Wistar albino rat extensor digitorumlongus muscle, which were exposed to AD extract prepared at different concentrations according to the maximum non-toxic concentration (MnTC) value, were recorded at frequencies of 1, 10, 20, 40, 80 and 100 Hz. As a result, an increase in mechanical response was observed, at 1/16 and 1/32 concentrations of the MnTC value compared to the control in the frequencies 20, 40, 80 Hz and 40, 80 Hz, respectively, and a decrease was observed at higher concentration values.}, number={2}, publisher={Karamanoglu Mehmetbey University}