@article{article_1033112, title={Evaluation of Antioxidant Activity of 1, 2, 4-Triazole Derivatives With Morpholine Moiety}, journal={Hacettepe University Journal of the Faculty of Pharmacy}, volume={42}, pages={73–82}, year={2022}, DOI={10.52794/hujpharm.1033112}, author={Shcherbyna, Roman and Pruhlo, Yevhen and Duchenko, Maryna and Kulagina, Mariia and Kudria, Victoriia and Valentyna, Vashchuk}, keywords={1.2.4-triazole, antioxidant activity, in vitro method}, abstract={The aim of the work was to study the antioxidant activity of 4-R-3- (morpholinomethyl)-4H-1,2,4-triazole-5-thioles and their alkyl derivatives in vitro using the method of non-enzymatic initiation of lipid peroxidation. Among the 45 compounds studied, 8 showed varying degrees of AOA. The most pronounced AOA has 4-amino-3-(morpholinomethyl)-4H-1,2,4-triazole-5-thiol. It was found that in most cases the introduction in alkyl-derivatives of 4-R-3-(morpholinomethyl)-4H-1,2,4-triazole-5-thioles free amino group or phenyl substituent to the N4 atom of the 1,2,4-triazole nucleus, accompanied with increasing of AOA for test substances. In almost all cases, the presence on the N4 atom of 1,2,4-triazole nucleus methyl or ethyl groups has the opposite effect, even in comparison with control groups.}, number={2}, publisher={Hacettepe University}, organization={The Ministry of Education and Science of Ukraine}