@article{article_1045740, title={The significance of ferritin, lipid-associated sialic acid, CEA, squamous celi carcinoma SCC antigen, and CYFRA 21-1 levels in SCC of the head and neck}, journal={The Turkish Journal of Ear Nose and Throat}, volume={12}, pages={23–30}, year={2004}, author={İnal, Erdoğan and Laçin, Meliha and Asal, Korhan and Ceylan, Alper and Köybaşıoğlu, Ahmet and İleri, Fikret and Uslu, Sabri}, keywords={Carcinoma, squamous cell/blood, head and neck neoplasms/blood, tumor markers, biological/blood}, abstract={Objectives: We investigated the value of some tumor markers in the diagnosis and treatment follow-up of squa- mous celi carcinoma of the head and neck.Patients and Methods: Ferritin, lipid-associated sialic acid LSA , carcinoembryonic antigen CEA , squamous celi car­ cinoma SCC antigen and CYFRA 21-1 levels were determined in 28 patients with squamous celi carcinoma and in a control group of 20 patients with benign lesions of the head and neck. The measurements were made before treatment and in the first and third months of treatment.Results: The sensitivity rates were as follovvs: 10.7% for fer­ritin, 89.3% for LSA, 21.4% for CEA, 42.9% for SCC antigen, and 14.3% for CYFRA 21-1. The specificity was 100% for ali the markers. The sensitivity increased to 96.4% when CEA and LSA were used in combination. Declines in the levels after treatment were significant for ferritin, CEA, SCC antigen, and LSA. No significant relationship was found betvveen the marker levels and lymph node metastasis, stage, and histologic differentiation of the tumors. Only ferritin and LSA levels were correlated with tumor size. Squamous celi carcinoma antigen was the only marker that manifested high levels in patients who developed locoregional recurrence and/or mortality.Conclusion: Of the markers studied, LSA, CEA and SCC antigen may be of value in the evaluation of squamous celi carcinoma of the head and neck. Sensitivity and specificity rates may increase when they are used in combination.}, number={1}, publisher={Istanbul University}