@article{article_1046086, title={Cytokine levels in nasal secretions in asthmatic and nonasthmatic patients with nasal polyposis}, journal={The Turkish Journal of Ear Nose and Throat}, volume={20}, pages={111–117}, year={2010}, author={Perić, Aleksandar and Vojvodić, Danilo and Radulović, Vesna and Miljanović, Olivera}, keywords={Allergy, asthma, cytokines, nasal polyps, nasal secretions}, abstract={Objectives: The aim of this study was to compare the cytokine levels of subjects with nasal polyps NP and comorbid asthma and NP patients without asthma. Patients and Methods: Thirty patients with NP 15 asthmatic and 15 nonasthmatic were included in this prospective study. Nasal secretion samples were collected from the nasal cavities of all subjects. The levels of eleven cytokines TNF-a, TNF-b, IL-1b, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, and IFN-g were measured using flow cytometric method. Results: The concentrations of Th2 cytokines IL-5, IL-6 and IL-10 were significantly higher in patients with NP and asthma compared with subjects with NP without asthma. IFN-g, IL-4, IL-6 and IL-10 levels were found significantly higher in allergic patients with NP and asthma compared with those without asthma. In nonallergic patients with NP and asthma, the concentrations of TNF-a, IL-5 and IL-6 were significantly higher than in nonallergic patients with NP without asthma. Conclusion: Our results showed that the presence of Th2 cytokines, especially IL-5 and IL-6 in patients with NP and asthma is a prominent feature that relates to increased eosinophilic inflammation. We also found significant influence of asthma and allergy on the cytokine profiles in nasal secretions of patients with NP.}, number={3}, publisher={Istanbul University}