@article{article_1046611, title={Post-radiotherapy hypothyroidism in head and neck cancers: When should we be concerned?}, journal={The Turkish Journal of Ear Nose and Throat}, volume={27}, pages={269–275}, year={2017}, author={Çelik, Mehmet and Meral, Rasim and Kanlıada, Deniz and Aydemir, Levent and Başaran, Bora and Kıyak, Erkan}, keywords={Head and neck cancers, hypothyroidism, mean radiation dose of thyroid gland, radiotherapy thyroid gland}, abstract={Objectives: This study aims to analyze the incidence of hypothyroidism HT in patients who underwent radiotherapy RT for head and neck cancers HNC , and to determine risk factors. Patients and Methods: This study was a retrospective analysis of patients who were treated with RT alone or in combination with surgery and/or chemotherapy between January 2005 and May 2012. Patients were grouped according to the primary tumor site, TNM staging system, age, gender, total radiation dose TRD , mean radiation dose of thyroid gland MRT , neck dissection, and chemotherapy. Results: A total of 90 patients who were treated with RT were analyzed. The median age was 52±13 range, 12-87 years. The histopathologic finding of 88 patients was squamous cell carcinoma, others were adenocystic carcinoma and undifferentiated carcinoma. The median follow-up of all patients after RT was 15 range, 6-72 months. Post-radiotherapy HT was found in 31 patients 34.4% . In this group, clinical and subclinical HT was present in eight 26% and 23 74% patients, respectively. Age younger than 60 years and increased MRT especially mean thyroid dose 20 Gy < were significant risk factors for post-radiotherapy HT p <0.05 . Conclusion: Physicians should pay more attention to HT in patients who were treated with RT for HNC during follow-up.}, number={6}, publisher={Istanbul University}