TY - JOUR T1 - Moksifloksasine Bağlı Anafilaksi Sonrası Bigemine Ventriküler Ekstrasistol Gelişen Olgu TT - A Case Developing Bigemina Ventricular Extrasystole After Moxifloxacin-Induced Anaphylaxis AU - Hasgül, Burak AU - Akdoğan, Halil İbrahim AU - Karaman, Serhat AU - Çatak, Arif İsmet PY - 2022 DA - September DO - 10.31832/smj.1050439 JF - Sakarya Tıp Dergisi PB - Sakarya University WT - DergiPark SN - 2146-409X SP - 572 EP - 576 VL - 12 IS - 3 LA - tr AB - Anafilaksi; alerjen bir madde ile karşılaşma sonrası ani gelişen, müdahelede geç kalınması durumunda dolaşımsal ve solunumsal problemlere yol açarak hayati tehdit oluşturan, multisistemik bir hipersensitivite reaksiyonudur. Anafilaksiye sıklıka ilaçlar, böcek ısırmaları ve besinler sebep olur. Anafilaksi durumunda kardiyak yan etkiler görülmesi sonucu disritmiler gözlenebilir. Biz olgumuzda üst solunum yolu enfeksiyonu tedavisi amaçlı kinolon grubu bir antibiyotik olan moksifloksasin tabletin altıncı dozu sonrası anafilaksi ve beraberinde ender görülen ventriküler disrtimi gelişen hastayı sunduk. KW - Anafilaksi KW - Moksifloksasin KW - Ventriküler Ekstrasistol N2 - Anaphylaxis is a multisystemic hypersensitivity reaction that develops suddenly after exposure to an allergenic substance, and causes life-threatening circulatory and respiratory problems if the intervention is delayed. Anaphylaxis is often caused by drugs, insect bites, and food. In case of anaphylaxis, dysrhythmias may be observed as a result of cardiac side effects. In our case, we presented a patient who developed anaphylaxis and concomitant ventricular dysrhythmia after the sixth dose of moxifloxacin tablet, a quinolone antibiotic for the treatment of upper respiratory tract infection. CR - 1- Simons FE. 9. Anaphylaxis. J Allergy Clin Immunol 2008; 121(2 Suppl): S402-7. CR - 2- Jerschow E, Lin RY, Scaperotti MM, McGinn AP. Fatalanaphylaxis in the United States, 1999-2010: temporal patterns and demographic associations. J Allergy Clin Immunol 2014; 134: 1318-28. CR - 3- Solensky R. Allergyto β-lactam antibiotics. J Allergy Clin Immunol 2012; 130: 1442-2. CR - 4- Patel TK, Patel PB, Barvaliya MJ, Tripathi CB. Drug-induced anaphylactic reactions in Indian population: A systematic review. Indian J Crit Care Med 2014; 18: 796-806. CR - 5- Aun MV, Blanca M, Garro LS, Ribeiro MR, Kalil J, Motta AA, et al. Nonsteroidal anti-inflammatory drugs are major causes of drug-induced anaphylaxis. J Allergy Clin Immunol Pract 2014; 2: 414-20. CR - 6- Dona I, Blanca-Lopez N, Torres MJ, Garcia-Campos J, Garcia-Nunez I, Gomez F, et al. Drug Hypersensitivity reactions: response patterns, Drug involved, and temporal variations in a large series of patients. J Investig Allergol Clin Immunol 2012: 22: 363-71. CR - 7- De Silva IL, Mehr SS, Tey D, Tang ML. Pediatric anaphylaxis: A 5 year retrospective review. Allergy 2008;63(8):1071-6. CR - 8- Simons KJ, Simons FE. Epinefrin ve anafilakside kullanımı: güncel konular. Curr Opin Allergy Clin Immunol 2010; 10:3054. CR - 9- Kounis NG. Koroner aşırı duyarlılık bozukluğu: Kounis sendromu. Clin Ther 2013; 35:563. CR - 10- Civelek E, Erkoçoğlu M, Akan A, Özcan C, Kaya A, Vezir E, et al. The Etiology and Clinical Features of Anaphylaxis in a developing country: A nation wide survey in Turkey. AsianPac J Allergy Immunol 2017; 35: 212-9. CR - 11- Gelincik A, Demirtürk M, Yılmaz E, Ertek B, Erdogdu D, Çolakoğlu B, et al. Anaphylaxis in a tertiary adult allergy clinic: a retrospective review of 516 patients. Ann Allergy Asthma Immunol 2013; 110: 96-100. CR - 12- Blanca-Lopez N, Andreu I, Jean MJT. Hypersensitivity reactions to quinolones. Curr Opin Allergy Clin Immunol 2011;11: 285-91. CR - 13- Demir S, Gelincik A, Akdeniz N, Aktas-Cetin E, Olgac M, Unal D, et al. Usefulness of in vivo and in vitro diagnostic tests in the diagnosis of hypersensitivity reactions to quinolones and in the evaluation of cross reactivity: a comprehensive study including the latest quinolone gemifloxacin. Allergy Asthma Immunol Res 2017; 9: 347-59. CR - 14- Top P, Mandell L, Patou G, et al. Yeni bir solunum florokinolonu, oral gemifloksasin: bağlamda bir güvenlik profili. Int J Antimicrob Ajanları 2004; 23:421. CR - 15- Karakuş, A. , Akçay, A. B. , Çelik, M. M. , Arıca, S. , Taşın, V. , Çalışkan, K. "Acute Atrial Fibrillation and Anaphylaxis due to Bee Sting: Case Report". Journal of Emergency Medicine Case Reports 5 (2014 ): 13-16 CR - 16- Ray WA, Murray KT, Salon K, et al. Azitromisin ve kardiyovasküler ölüm riski. N Engl J Med 2012; 366:1881. UR - https://doi.org/10.31832/smj.1050439 L1 - https://dergipark.org.tr/en/download/article-file/2164703 ER -