@article{article_1054490, title={Evaluation of clinicopathological and prognostic significance of RDW in gastric cancer}, journal={Journal of Medicine and Palliative Care}, volume={3}, pages={7–15}, year={2022}, DOI={10.47582/jompac.1054490}, author={Özdemir, Dursun Burak and Karayiğit, Ahmet and Dizen, Hayrettin and Ünal, Bülent}, keywords={Gastric cancer, Red cell distribution width, RDW, prognosis, overall survival}, abstract={Objective: We aimed to reveal possible relationships between pre-operative RDW values and clinicopathological features of gastric cancer (GC) and to evaluate its predictive impact on progression and prognosis of GC. Material And Method: A total of 92 patients who underwent curative surgery were retrospectively included the study. GC patients were divided into two groups: high-RDW group (>14.5%, n=58) and low-RDW ( <14.5%, n=34). Results: The optimal pre-operative RDW cut-off value to predict mortality in GC patients was 14.5% (AUC=0.690, p=0.010). Increased tumor size and decreased albumin and hemoglobin values were found in the high-RDW group (p=0.036, 0.003 and <0.001, respectively). The 5-year overall survival (OS) rates were 17.6±5% in patients with high-RDW and 44.5±9% in the low-RDW group (p <0.001). Cox regression analysis showed perineural invasion, surgical margin positivity, N3 stage, leakage and high RDW were independent prognostic factors for mortality. Conclusion: Our results indicate that RDW is associated with GC pathogenesis and tumor progression. Pre-operative RDW may be a non-invasive, easily accessible and reliable indicator to predict survival in patients with GC.}, number={1}, publisher={MediHealth Academy Yayıncılık}