TY  - JOUR
T1  - Evaluation of Helicobacter pylori Infection with Endoscopic, Pathological, and Laboratory Findings
TT  - Helikobakter pylori İnfeksiyonunun Endoskopik, Patolojik ve Laboratuvar Bulguları ile Değerlendirilmesi
AU  - Avcı, Mehmet Alperen
AU  - Fidan, Merve Nergis
AU  - Kaya, İsmail Oskay
PY  - 2022
DA  - June
DO  - 10.18663/tjcl.1067301
JF  - Turkish Journal of Clinics and Laboratory
JO  - TJCL
PB  - DNT Ortadoğu Yayıncılık A.Ş.
WT  - DergiPark
SN  - 2149-8296
SP  - 202
EP  - 206
VL  - 13
IS  - 2
LA  - en
AB  - Aim: Helicobacter pylori, the most common bacterial infestation in the gastrointestinal tract. It is known to role in thedevelopment of intestinal metaplasia, dysplasia, gastric cancer, and atrophic gastritis. H. pylori infection has been thought to berelated with many diseases such as iron deficiency, vitamin b deficiency…In our study, we aimed to evaluate the patients whounderwent endoscopic examination in terms of endoscopic, pathological and laboratory (Hemogram and iron values) findings.Material and Methods: Between October 2020 and July 2021, 322 patients who were requested endoscopic examinationand laboratory examination due to gastrointestinal system complaints were included in the study.Results: In our study; 152 H. pylori negative cases and 170 Helicobacter pylori positive cases were detected. Helicobacter pylorinegative (HP-) group, the number of men was 50 and the number of women was 102. In the HP+ group, the number of men was61 and the number of women was 109 (P=0.6387). The mean age in the (HP-) group was 51.48 ± 1.260. The mean age in the HP+group was 48.29 ± 1.215 (P=0.0700). HGB value in the HP- group was 13.66 ± 0.1249, and in the HP+ group, it was found 13.95± 0.1359 (P=0.1194). The mean MCV value was found to be 85.74 ± 0.4877 in the HP- group, and 85.69 ± 0.5860 (P=0.9505) inthe HP+ group. The mean Ferritin value in the HP- group was 38.71 ± 2.979, and 44.38 ± 3.195 (P=0.1983) in the HP+ group. Inaddition, 31 cases with Pangastritis in the HP- group and 54 cases in the HP+ group were detected (p=0.0208).Conclusion: In our study; the endoscopic, laboratory and pathological findings of HP infection were examined, nosignificant relationship was found between age, gender, HGB, MCV and Ferritin values with HP infection. There is nonegative correlation with Antral gastritis and Atrophic gastritis in gastritis cases, a significant correlation was foundbetween pangastritis and HP (p=0.0208)
KW  - ENDOSCOPY
KW  - HELICOBACTER PYLORI
KW  - FERRITIN
N2  - Amaç: Helicobacter pylori, gastrointestinal sistemdeki en yaygın bakteridir. Bağırsak metaplazisi, displazi, mide kanserive atrofik gastrit gelişiminde rol oynadığı bilinmektedir. H. pylori enfeksiyonunun demir eksikliği, B vitamini eksikliği gibibirçok hastalıkla ilişkili olduğu düşünülmüştür… Çalışmamızda endoskopik inceleme yapılan hastaların endoskopik,patolojik ve laboratuvar (hemogram ve demir değerleri) bulguları açısından değerlendirmeyi amaçladık.Gereç ve yöntemler: Ekim 2020 - Temmuz 2021 tarihleri arasında gastrointestinal sistem şikayetleri nedeniyle endoskopikmuayene ve laboratuvar tetkiki istenen 322 hasta çalışmaya dahil edildi.Bulgular: Çalışmamızda; 152 H. pylori negatif vaka ve 170 Helicobacter pylori pozitif vaka tespit edildi. Helicobacter pylorinegatif (HP-) grubunda erkek sayısı 50, kadın sayısı 102 idi. HP+ grubunda erkek sayısı 61, kadın sayısı 109 idi (P=0,6387).(HP-) grubundaki yaş ortalaması 51,48 ± 1,260 idi. HP+ grubunda ortalama yaş 48,29 ± 1,215 (P=0.0700) idi. HP- grubundaHGB değeri 13,66 ± 0.1249, HP+ grubunda 13,95 ± 0,1359 (P=0,1194) bulundu. Ortalama MCV değeri HP- grubunda 85,74 ±0,4877, HP+ grubunda 85,69 ± 0,5860 (P=0,9505) olarak bulundu. HP- grubunda ortalama Ferritin değeri 38,71 ± 2,979, HP+grubunda 44,38 ± 3,195 (P=0,1983) idi. Ayrıca HP- grubunda 31, HP+ grubunda 54 Pangastrit vakası tespit edildi (p=0,0208).Sonuç: Çalışmamızda; HP enfeksiyonunun endoskopik, laboratuvar ve patolojik bulguları incelendiğinde, HP enfeksiyonuile yaş, cinsiyet, HGB, MCV ve Ferritin değerleri arasında anlamlı bir ilişki bulunmadı. Gastritli olgularda Antral gastrit veAtrofik gastrit ile negatif korelasyon bulunmazken, pangastrit ile HP arasında anlamlı korelasyon bulundu (p=0.0208).
CR  - 1. Graham DY, Malaty HM, Evans DG, Evans DJ Jr., Klein PD, Adam
E. Epidemiology of Helicobacter pylori in an asymptomatic
population in the United States. Effect of age, race, and
socioeconomic status. Gastroenterology 1991; 100: 1495-501.
CR  - 2. Lehours P, Yilmaz O. Epidemiology Helicobacter pylori infection.
Helicobacter 2007; 12 : 1-3.
CR  - 3. Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of
patients with gastritis and peptic ulceration. Lancet 1984; 1: 13115.
CR  - 4. Schirer WH, Schoengold RJ, Baker JT, et al. Development of
FlexSure HP-an immunochromatographic method to detect
antibodies against Helicobacter pylori. Clin Chem 1998; 44: 293-8.
CR  - 5. Kikuchi S, Wada O, Nakajima T, et al. Serum antiHelicobacter
pylori antibody and gastric carcinoma among young adults.
Cancer 1995; 75: 2789-93.
CR  - 6. Craanen ME, Dekker W, Blok P, Ferwerda J, Tytgat GN. Intestinal
metaplasia and Helicobacter pylori: an endoscopic bioptic study
of the gastric antrum. Gut 1992; 33: 16-20.
CR  - 7. Everhart JE. Recent developments in the epidemiology of
Helicobacter pylori. Gastroenterology Clinics of North America
2000; 29: 559-79.
CR  - 8. Coyne D. Iron indices: what do they really mean? Kidney Int
Suppl 2006: S4-8.
CR  - 9. Milman N, Rosenstock S, Andersen L, Jorgensen T, Bonnevie O.
Serum ferritin, hemoglobin, and Helicobacter pylori infection:
a seroepidemiologic survey comprising 2794 Danish adults.
Gastroenterology 1998; 115: 268-74.
CR  - 10. Şengül D, Şengül İ. Helikobakter Pilori Sıklığı ve Lokasyon,
Altı Adet Yaş Grubu ve Anatomik Pilot Bölge Bazlı 50 Yaş
Sınır Değerlendirmesinin, Histopatolojik Helikobakter Pilori
Kolonizasyon Derecesi ile İlişkileri. Med J Bakirkoy 2018; 14: 381-8.
CR  - 11. World Gastroenterology Organisation. WGO Practice Guideline:
Helicobacter pylori in Developing Countri¬es. 2005.
CR  - 12. Megraud F. Epidemiology of Helicobacter pylori infection:
Helicobacter pylori. Gastroenterology Clin Nort America 1993;
22: 73-88.
CR  - 13. The Eurogast Study Group. Epidemioloji of and risk faktor for
Helicobacter pylori infection among 3194 asemptomatic subject
in populations. GUT 1993; 34: 1672-6.
CR  - 14. Selek MB, Bektöre B, Atik TK, Özyurt M. Üçüncü basamak
bir hastanede dispeptik yakınmaları olan hastaların dışkı
örnekle¬rinde Helicobacter pylori antijen pozitifliğinin
değerlendiril¬mesi. Dicle Med J 2013; 40: 574-8.
CR  - 15. Erçetin C, Dural AC, Yiğitbaş H, Yavuz E, Çelebi F, Borucu İ, Özcan
TB, Alış H. Helikobakter pylori infeksiyonunun endoskopik,
patolojik ve laboratuvar bulguları açısından değerlendirilmesi.
İKSSTD 2021; 13: 25-30.
CR  - 16. Cardenas VM, Mulla ZD, Ortiz M, Graham DY. Iron deficiency
and Helicobacter pylori infection in the United States. Am J
Epidemiol 2006; 163: 127-34.
CR  - 17. Park SA, Lee HW, Hong MH, Choi YW, Choe YH, Ahn BY, et al.
Comparative proteomic analysis of Helicobacter pylori strains
associated with iron deficiency anemia. Proteomics 2006; 6: 1319-28.
CR  - 18. Erdem ME, Keçici S, Akın S, ve ark. Demir eksikliği anemisi ile
helikobakter pilori arasındaki ilişki. Eur Arch Med Res 2014; 30: 82-5.
CR  - 19. Nalbant A, Aydın A. Helicobakter pylori enfeksiyonunun D
vitamini, hemogram parametreleri ve kan grubu ile ilişkisi. The
Turkish Journal of Academic Gastroenterology 2017;16: 01-05.
CR  - 20. Hershko C, Ianculovich M, Souroujon M. A hematologist’s view
of unexplained iron deficiency anemia in males: impact of
Helicobacter pylori eradication. Blood Cells Mol Dis 2007; 38: 45-53.
CR  - 21. Zuberi BF, Afsar S, Qadeer R, Baloch I, Quraishy MS, Kumar A,
Akhtar N. Hemogolbin, ferritin, vitamin B12 and halicobacter
pylori infection: a study in patients who underwent upper gi
endoscopy at civil hospital karachi. J Coll Physicians Surg Pak.
2007; 17: 546-9.
CR  - 22. Gisbert JP, Calvet X. Review article: Helicobacter pylori-negative
duodenal ulcer disease. Aliment Pharmacol Ther 2009; 30: 791-815.
CR  - 23. Kuipers EJ, Uyterlinde AM, Peña AS, et al. Long-term sequelae of
Helicobacter pylori gastritis. Lancet 1995; 345: 1525-8.
UR  - https://doi.org/10.18663/tjcl.1067301
L1  - https://dergipark.org.tr/en/download/article-file/2229169
ER  -