@article{article_1082490, title={A Magic Relationship Between Trigeminal Network and Carotico-vertebrobasilar Vasculature During Craniofaciocervical Recirculation Following Bilaterally Common Carotid Artery Ligation: Preliminary Study}, journal={Medical Journal of Western Black Sea}, volume={6}, pages={9–15}, year={2022}, DOI={10.29058/mjwbs.1082490}, author={Olğun, Abdulkerim and Demirtaş, Rabia and Alpaslan Duman, Aslıhan and Karadağ, Mehmet Kürşat and Şahin, Mehmet Hakan and Özmen, Sevilay and Aydin, Mehmet}, keywords={Carotid ligation, trigeminal ganglion, external carotid artery, internal carotid artery, revascularisation}, abstract={Aim: Steno-occlusive carotid artery disease causes increased intraluminal pressure, retrograde blood flow, intraluminal enlargement, vessel wall thinning, convolution, vascular remodelling, angiogenesis, and aneurysm formation. We investigated whether there is a relationship between trigeminal ganglion (TGG) ischemia and luminal surface area values of external/internal carotid arteries (ECA/ICA) after common carotid artery ligation (BCCAL). Material and Methods: This study was conducted in 20 hybrid male rabbits as control (GA;n=5), SHAM (GB;n=5), and study group (GC,n=10). Following anterior mid-cervical incision, permanent BCCAL was performed for only GC and animals sacrificed under general anaesthesia after three months. Degenerated neuron (DN) density of TGGs and ECAs/ICAs’ luminal surface values were estimated by Cavalieri and Stereological methods. Lumen enlargement, wall thinning, elongation, convolution, and dolichoectasia were detected in the carotid artery vasculature. Results: The mean DN density of TGG was 12±4 in GA, 53±11 in GB, and 960±112 in GC. The mean number of ECA branches was calculated as 4±1/GA, 7±2/GB, and 11±3/GC. Total surface values of ECA/ICA (as mm2): 4.8±1.2/GA; 3.9±0.8/GB and 3.6±0.4/GC. Conclusion: The low density of DN in TGG could have a beneficial effect on neovascularization, collateral development, a renormalization of carotid circulation, and prevention of ischemic damage supplied by ECA/ICA of study group.}, number={1}, publisher={Zonguldak Bulent Ecevit University}