TY - JOUR T1 - Efficacy of high-dose methylprednisolone as a first-line therapy in adult patients with immune thrombocytopenia TT - İmmün trombositopenili erişkin hastalarda birinci basamak tedavide yüksek doz metilprednizolonun etkinliği AU - Aydın, Kaniye AU - Gürkan, Emel PY - 2022 DA - June Y2 - 2022 DO - 10.17826/cumj.1085840 JF - Cukurova Medical Journal JO - Cukurova Med J PB - Cukurova University WT - DergiPark SN - 2602-3032 SP - 715 EP - 721 VL - 47 IS - 2 LA - en AB - Purpose: We aimed to compare the efficacy of high-dose methylprednisolone (HDP) with intravenous immunoglobulin (IVIG) and conventional prednisolone (CDP) as a first-line therapy in adult patients with immune thrombocytopenia (ITP). Materials and Methods: This retrospective study included 140 adult patients with either previously untreated newly diagnosed ITP (n=51) or persistent or chronic ITP (n=22/n=67)) with episodes. Patients with a platelet count KW - Idiopathic thrombocytopenic purpura KW - treatment KW - intravenous immune globulin KW - methylprednisolone N2 - Amaç: İmmün trombositopenili (İTP) erişkin hastalarda birinci basamak tedavi olarak yüksek doz metilprednizolon (HDP) ile intravenöz immünoglobulin (İVİG) ve konvansiyonel prednizolonun (CDP) etkinliğini karşılaştırmayı amaçladık.Gereç ve Yöntem: Bu retrospektif çalışma, daha önce tedavi edilmemiş yeni tanı konmuş İTP (n=51) veya epizodları olan kalıcı (n=22) ya da kronik İTP (n=67)’li 140 yetişkin hastayı içermektedir. Trombosit sayısı CR - Abrahamson PE, Hall SA, Feudjo-Tepie M, et al. The incidence of idiopathic thrombocytopenic purpura among adults: a population based study and literature review. Eur J Haematol. 2009;83(2):83-89. CR - Schoonen WM, Kucera G, Coalson J, et al. Epidemiology of immune thrombocytopenic purpura in the General Practice Research Database. Br J Haematol. 2009;145(2):235-44. CR - Segal JB, Powe NR. Prevalence of immune thrombocytopenia: analyses of administrative data. J Thromb Haemost. 2006;4(11):2377-83. CR - Terrell DR, Beebe LA, Vesely SK, Neas BR, Segal JB, George JN. The incidence of immune thrombocytopenic purpura in children and adults: a critical review of published reports. Am J Hematol. 2010;85(3):174-80. CR - Yong M, Schoonen WM, Li L, Kanas G,et al. Epidemiology of paediatric immune thrombocytopenia in the General Practice Research Database. Br J Haematol.2010;149(6):855-64. CR - Kistangari G, McCrae KR. Immune thrombocytopenia. Hematol Oncol Clin North Am. 2013; 27:495-520. CR - Neunert C, Terrell DR, Arnold DM, et al. American Society of Hematology 2019 guidelines for immune thrombocytopenia. Blood Adv. 2019 Dec 10;3(23):3829-66. CR - Rodeghiero F, Stasi R, Gernsheimer T, et al. Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group. Blood. 2009 Mar 12;113(11):2386-93. CR - Provan D, Arnold DM, Bussel JB, et al. Updated international consensus report on the investigation and management of primary immune thrombocytopenia. Blood Adv. 2019;3(22):3780-3817. CR - Godeau B, Chevret S, Varet B, et al; French ATIP Study Group. Intravenous immunoglobulin or high-dose methylprednisolone, with or without oral prednisone, for adults with untreated severe autoimmune thrombocytopenic purpura: a randomised, multicentre trial. Lancet. 2002 Jan 5;359(9300):23-9. CR - Kim CH, Choi YS, Moon JY, et al. Methylprednisolone versus intravenous immune globulin as an initial therapy in adult primary immune thrombocytopenia. Korean J Intern Med. 2019 Mar;34(2):383-89. CR - Mazzucconi MG, Fazi P, Bernasconi S, et al; Gruppo Italiano Malattie EMatologiche dell'Adulto (GIMEMA) Thrombocytopenia Working Party. Therapy with high-dose dexamethasone (HD-DXM) in previously untreated patients affected by idiopathic thrombocytopenic purpura: a GIMEMA experience. Blood. 2007 Feb 15;109(4):1401-7. CR - Cheng Y, Wong RS, Soo YO, et al. Initial treatment of immune thrombocytopenic purpura with high-dose dexamethasone. N Engl J Med. 2003 Aug 28;349(9):831-6. CR - Borst F, Keuning JJ, van Hulsteijn H, et al. High-dose dexamethasone as a first- and second-line treatment of idiopathic thrombocytopenic purpura in adults. Ann Hematol. 2004 Dec;83(12):764-8. CR - Mashhadi MA, Kaykhaei MA, Sepehri Z, Miri-Moghaddam E. Single course of high dose dexamethasone is more effective than conventional prednisolone therapy in the treatment of primary newly diagnosed immune thrombocytopenia. Daru. 2012 Aug 28;20(1):7. CR - Provan D, Stasi R, Newland AC,et al. International consensus report on the investigation and management of primary immune thrombocytopenia. Blood. 2010 Jan 14;115(2):168-86. UR - https://doi.org/10.17826/cumj.1085840 L1 - https://dergipark.org.tr/en/download/article-file/2301993 ER -