@article{article_1089254, title={Synthesis and characterization of new Piperazine-Dithiocarbamate compounds as potent MAO-A inhibitors}, journal={European Journal of Life Sciences}, volume={1}, pages={1–7}, year={2022}, DOI={10.55971/EJLS.1089254}, author={Osmaniye, Derya and Saglik, Begüm Nurpelin and Levent, Serkan and Özkay, Yusuf and Kaplancıklı, Zafer Asım}, keywords={Dithiocarbamate, HRMS, Monoamine oxidase, NMR, Piperazine}, abstract={<div style="text-align:justify;">Monoamine oxidase (MAO) enzymes have an important place in neurodegenerative diseases. While MAO-A inhibitors are used in depression; MAO-B enzyme has an important place in Parkinson’s disease. Within the scope of this study, 7 new piperazine-dithiocarbamate derivative compounds were synthesized. Structure determinations of the compounds were performed using 1H-NMR, <sup>13 </sup>C-NMR and HRMS spectroscopic methods. The MAO inhibitory activities of the compounds were determined by in vitro fluorometric methods. According to the obtained results, compound 2d with IC <sub>50 </sub>=0.108±0.004 µM; compound 2e exhibited inhibitory activity with an IC <sub>50 </sub>=0.074±0.003 µM. </div>}, number={1}, publisher={Anadolu University}