TY - JOUR T1 - The Value of Indirect Biomarkers in the Monitoring of Hepatitis C Virus Infection at the Mogadishu Hospital, Somalia TT - Somali Mogadişu Hastanesinde Hepatit C Virüsü Enfeksiyonunun İzlenmesinde Dolaylı Biyobelirteçlerin Değeri AU - Sarı, Öznur PY - 2022 DA - August Y2 - 2022 DO - 10.29058/mjwbs.1100914 JF - Medical Journal of Western Black Sea JO - Med J West Black Sea PB - Zonguldak Bulent Ecevit University WT - DergiPark SN - 2822-4302 SP - 158 EP - 164 VL - 6 IS - 2 LA - en AB - Aim: We aimed to investigate the value of Class II fibrosis markers as predictors of liver diseaseprogress, and changes in platelet parameters in the laboratory tests of patients with Hepatitis C virusinfection [anti-HCV (+)]admitted to the Somalia Mogadishu Hospital.Material and Methods: All patients older than 18 years old, who were examined in our hospital’swere included in the study. Accompanied by CBC and biochemical measurement results from patients,indirect liver fibrosis (Class II) markers AAR (AST/ALT ratio), APRI (AST/Plt ratio index) and FIB-4index (Age (year) x AST (U/L) / [Platelet count (109 / L)] x (ALT) 1/2 (U / L)], MPV/Platelet ratio, APRI =[(person AST/AST reference upper limit) x Platelet (103 /ml) x 100] were calculated.Results: A total of 2,887 patients, 1,605 (55.6%) male and 1,282 (44.4%) female, with a median ageof 51 (32-67) years, were included in our study. The anti-HCV positivity rate was found to be 1.5 timeshigher in men than women.APRI, MPV / Plt R and RPR levels, indirect markers of liver damage, werefound to be higher in patients with anti-HCV (+) than those in the control group (p KW - Anti-HCV KW - MPV/Plt ratio KW - AAR KW - APRI KW - FIB-4 N2 - Amaç: Somali Mogadişu Hastanesi’ne başvuran Hepatit C virüsü enfeksiyonu [anti-HCV (+)]olan hastaların laboratuvar testlerinde, karaciğer hastalığının ilerlemesini öngören Sınıf II fibrozisbelirteçlerinin değerini ve trombosit parametrelerindeki değişiklikleri araştırmayı amaçladık.Gereç ve Yöntemler: Hastanemizde muayene edilen 18 yaş üstü tüm hastalar çalışmaya dahil edildi.CBC ve hastalardan alınan biyokimyasal ölçüm sonuçları eşliğinde, dolaylı karaciğer fibrozu (Sınıf II)belirteçleri AAR (AST/ALT oranı), APRI (AST/Plt oran indeksi) ve FIB-4 indeksi (Yaş (yıl) x AST (U/L) )/ [Platelet sayısı (109 / L)] x (ALT) 1/2 (U / L)], MPV/Platelet oranı, APRI = [(kişi AST/AST referans üstlimiti) x Trombosit (103 /ml) x 100] hesaplandı.Bulgular: Çalışmamıza medyan yaşı 51 (32-67) yıl olan 1.605 (%55.6) erkek ve 1.282 (%44.4) kadınolmak üzere toplam 2.887 hasta dahil edildi. Erkeklerde anti-HCV pozitiflik oranı kadınlara göre 1,5 katdaha yüksek bulundu. Karaciğer hasarının dolaylı belirteçleri olan APRI, MPV / Plt R ve RPR düzeyleri,anti-HCV (+) olan hastalarda kontrol grubuna göre daha yüksek bulundu (p CR - 1. Averhoff FM, Glass N, Holtzman D. Global Burden of Hepatitis C: Considerations for Healthcare Providers in the United States. Clin Infect Dis. 2012 Jul 15;55(suppl_1):S10–5. https://doi.org/10.1093/cid/cis361 CR - 2. Daw MA, Dau AA. Hepatitis C virus in Arab world: a state of concern. Scientific World Journal. 2012;2012:719494. https://doi.org/10.1100/2012/719494 CR - 3. Hassan-Kadle MA, Osman MS, Ogurtsov PP. Epidemiology of viral hepatitis in Somalia: Systematic review and meta-analysis study. World J Gastroenterol. 2018 Sep 14;24(34):3927–57. https://doi.org/10.3748/wjg.v24.i34.3927 CR - 4. Loggi E, Vukotic R, Conti F, Gitto S, Andreone P. Gold standard assays for the monitoring of patients with chronic hepatitis C. 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