TY - JOUR T1 - Yenidoğanlarda Persistan Pulmoner Hipertansiyon Risk Faktörleri, Klinik ve Prognozun Belirlenmesi TT - Risk Factors for Persistent Pulmonary Hypertension of the Newborn and Determining the Clinical Prognosis AU - Yaşa, Beril AU - Dincer, Emre AU - Babayiğit, Aslan AU - Yılmaz Semerci, Seda AU - Memur, Şeyma AU - Sağlam, Özge AU - Gönen, İlker AU - Can Büker, Halime Sema AU - Özkan, Serhat AU - Bornaun, Helen AU - Öztarhan, Kazım AU - Çetinkaya, Merih PY - 2022 DA - September DO - 10.26650/jchild.2022.1113770 JF - Çocuk Dergisi PB - Istanbul University WT - DergiPark SN - 1308-8491 SP - 110 EP - 116 VL - 22 IS - 2 LA - tr AB - Amaç: Yenidoğanın persistan pulmoner hipertansiyonu (PPHN) geçiş döneminde pulmoner vasküler direncin yüksek kalması sonucu gelişen önemli morbidite ve mortalite ile sonlanabilen ciddi bir klinik durumdur. Bu çalışmada PPHN tanısıyla izlenen yenidoğan bebeklerde risk faktörlerinin belirlenmesi, klinik prognozun, mortalite ve morbiditelerin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Retrospektif gözlemsel bu çalışmada Ocak 2017-Ocak 2019 tarihileri arasında Yenidoğan Yoğun Bakım Ünitesinde (YYBÜ) PPHN tanısıyla izlenen bebeklerin verileri hastane kayıtlarından incelenmiş, PPHN etiyolojisi, bebeklerin klinik bulguları, morbiditeler ve mortalite değerlendirilmiştir. Bulgular: İki senelik çalışma periyodunda toplam 29.650 bebek dünyaya geldi, bebeklerin 920’si YYBÜ’de yatırıldı ve 50 bebekte PPHN saptandı. PPHN gelişen olguların %66’sı prematüre ve %52’si kız idi. PPHN gelişimi ile ilişkilendirilen en sık etiyolojik faktör term bebeklerde konjenital pnömoni (%65) iken, preterm bebeklerde respiratuar distres sendromu (%100) idi. Her iki grupta da en sık ikinci etiyolojik faktör perinatal asfiksi idi. Patent duktus arteriyozus, intraventriküler kanama, nekrotizan enterokolit ve bronkopulmoner displazi gibi morbiditeler PPHN gelişen preterm bebeklerde daha sık görülürken, mortalite oranı da preterm grupta daha yüksek bulundu. Tartışma: Persistan pulmoner hipertansiyon, uygun kardiyorespiratuvar destek ve güncel tedavilere rağmen yüksek neonatal mortaliteye sahip ciddi bir durumdur. Pulmoner hipertansiyon gelişimi ve mortalite üzerine etkili risk faktörlerinin belirlenmesi ile mortalite ve ilişkili morbiditelerin azaltılabileceği düşünülmektedir. KW - persistan pulmoner hipertansiyon KW - yenidoğan KW - preterm N2 - Objective: Persistent pulmonary hypertension of the newborn (PPHN) is a serious clinical condition that developed through the persistence of high pulmonary vascular resistance during the transition period and results in severe morbidities and mortality. This study aims to determine the risk factors for developing PPHN and to evaluate the prognosis, morbidities, and mortality. Materials and Method: This retrospective study was conducted between January 2017 and January 2019. Hospital records of infants who needed neonatal intensive care were evaluated retrospectively in terms of etiological causes of PPHN, clinical prognosis of neonates, morbidities, and mortality rates. Results: A total of 29,650 infants were born during the 2-year study period, 920 of whom were admitted to a neonatal intensive care unit, of which 50 developed PPHN. Of the infants who developed PPHN, 66% were preterm and 52% were female. The most common etiology related to developing PPHN is congenital pneumonia (65%) in term infants and respiratory distress syndrome (100%) in preterm infants. The second most common etiology is perinatal asphyxia for both term and preterm infants. 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