TY - JOUR T1 - The alterations of blood-testis barrier in experimental testicular injury models AU - Ercan, Feriha AU - Acıkel Elmas, Merve PY - 2022 DA - May DO - 10.5472/marumj.1114971 JF - Marmara Medical Journal JO - Marmara Med J PB - Marmara University WT - DergiPark SN - 1019-1941 SP - 249 EP - 253 VL - 35 IS - 2 LA - en AB - The blood-testis barrier is found between the Sertoli cells and divides the seminiferous tubule epithelium into basal and adluminalcompartments. The germinal cell renewal, differentiation and cell cycle progression up to the preleptotene spermatocytes stagetake place in the basal compartment, however, meiosis, spermiogenesis and spermiation take place in the adluminal compertment.The blood-testis barrier consists of tight junctions as well as ectoplasmic specialisations, desmosomes and gap junctions to createspecific microenvironment for the completion of spermatogenesis to form spermatozoa. The blood-testis barrier is not a staticultrastructure, it undergoes extensive restructuring during the seminiferous tubule epithelial cycle of spermatogenesis to allow thetransit of preleptotene spermotocytes at the blood-testis barrier from basal compartment towards the adluminal compartment.The functions of the blood-testis barrier include preventing the transport of biomolecules into the paracellular space, forming animmunological barrier, separating cellular processes during the spermatogenic epithelial cycle, and establishing the cellular polarityof the seminiferous tubule. However, various environmental conditions, chemotherapeutic agents, toxic substances and lifestyle havedegenerative effects on blood-testis barrier, resulting in testicular damage, altered sperm parameters and ultimately male infertility.The alterations in morphological and molecular organization of blood-testis barrier in different experimentally induced testis injurymodels are reviewed in this article. 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